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Butyrolactones,inhibitors of 5-lipoxygenase from fungal metabolites

Journal of Chinese Pharmaceutical Sciences 2010年第4期19卷 251-255页

作者：王福生可爱兵朱京童李业英路新华郑智慧张华马瑛任晓王亚婷赵宝华河北师范大学生命科学学院河北石家庄050016 华北制药集团新药研发中心河北石家庄050016

In our ongoing search for new inhibitors of 5-lipoxygenase（5-LOX） from microbial resources,Aspergillus F06Z-509 was found to produce active *** active compounds named F06Z-509-A,B and C were obtained and identified as butyrolactoneⅡ,ⅠandⅢby NMR and MS data *** showed inhibitory activity against 5-LOX with IC50 of 21.43, 22.51 and 11.83μg/mL,*** are shown to be inhibitors of 5-LOX for the first time.

关键词： 5-Lipoxygenase inhibitors Butyrolactones fungal metabolites

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fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells

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Acta Pharmaceutica Sinica B 2012年第1期2卷 23-27页

作者： Takashi Fukuda Ryuji Uchida Hiroyo Inoue Satoshi Ohte Hiroyuki Yamazaki Daisuke Matsuda Takenobu Katagiri Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyoJapan Research Center for Genomic Medicine Saitama Medical UniversitySaitamaJapan

Fibrodysplasia ossificans progressiva(FOP)is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues.A constitutively activated mutation of a bone morphogenetic protein(BMP)receptor,ALK2,has been identified in patients with *** report here that four structurally related compounds,lucilactaene,hydroxylucilactaene,NG-391 and NG-393,produced by fungal strain Fusarium sp.B88,inhibit BMP signaling in *** phosphatase activity,a marker enzyme of osteoblastic differentiation,was decreased in C2C12 myoblasts stably expressing mutant ALK2 by treatment with those compounds with IC_(50) values of 5.7,6.8,6.9 and 6.1 mM,***,NG-391 and NG-393 inhibited BMP-specific luciferase reporter activity,which is directly regulated by transcription factor Smads,with IC50 values of 1.4 and 2.1 mM,*** findings suggest that these fungal metabolites may provide a new direction in the development of FOP therapeutics.

关键词： Lucilactaenes fungal metabolites C2C12 myoblasts Fibrodysplasia ossificans progressiva

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Fusarium-produced vitamin B6 promotes the evasion of soybean resistance by Phytophthora sojae

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植物学报:英文版 2023年第9期65卷 2204-2217页

作者： Shuchen Wang Xiaoyi Zhang Zhichao Zhang Yun Chen Qing Tian Dandan Zeng Miao Xu Yan Wang Suomeng Dong Zhonghua Ma Yuanchao Wang Xiaobo Zheng Wenwu Ye Department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Plant Immunity Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Soybean Disease and Pest Control(Ministry of Agriculture and Rural Affairs) Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Plants can be infected by multiple pathogens concurrently in natural systems. However,pathogen–pathogen interactions have rarely been studied. In addition to the oomycete Phytophthora sojae, fungi such as Fusarium spp. also cause soybean root rot. In a 3-year field investigation, we discovered that P. sojae and Fusarium spp. frequently coexisted in diseased soybean roots. Out of 336 P. sojae–soybean–Fusarium combinations,more than 80% aggravated disease. Different Fusarium species all enhanced P. sojae infection when co-inoculated on soybean. Treatment with Fusarium secreted non-proteinaceous metabolites had an effect equal to the direct pathogen coinoculation. By screening a Fusarium graminearum mutant library, we identified Fusarium promoting factor of Phytophthora sojae infection 1(Fpp1),encoding a zinc alcohol dehydrogenase. Fpp1 is functionally conserved in Fusarium and contributes to metabolite-mediated infection promotion, in which vitamin B6(VB6) produced by Fusarium is key. Transcriptional and functional analyses revealed that Fpp1 regulates two VB6 metabolism genes, and VB6 suppresses expression of soybean disease resistance-related genes. These results reveal that co-infection with Fusarium promotes loss of P. sojae resistance in soybean, information that will inform the sustainable use of diseaseresistant crop varieties and provide new strategies to control soybean root rot.

关键词： fungal metabolites pathogen–host interaction Phytophthora sojae soybean root rot vitamin B6

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Effect of Crude Drug Extracts on Trypacidin Production in Aspergillus fumigatus

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Advances in Microbiology 2022年第9期12卷 541-554页

作者： Daigo Wakana Nobuhiro Inoue Hisashi Takeda Tomoo Hosoe Faculty of Pharmaceutical Sciences Hoshi University Shinagawa Tokyo Japan

We examined the production of fungal metabolites as biological responses to 120 crude drugs by culturing the filamentous fungus Aspergillus fumigatus CBS101355 with crude drugs and analyzing the culture extracts by HPLC. Nine crude drug extracts [Kyokatsu (Notopterygium), Kyonin (apricot kernel), Kujin (Sophora root), Goboshi (Burdock fruit), Goma (sesame), Shokyo (ginger), Shin’i (magnolia flower), Togashi (Benincasa seed), and Bukuryo (Poria sclerotium)] induced the production of trypacidin, which was not produced by culturing in potato dextrose broth without crude drugs.

关键词： Aspergillus fumigatus Crude Drug fungal metabolites Trypacidin

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