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Generation of functional organs from stem cells

Cell Regeneration 2013年第1期2卷 1-6页

作者： Yunying Liu Ru Yang Zuping He Wei-Qiang Gao State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRenji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Med-X Research Institute Shanghai Jiaotong UniversityShanghai 200127China

We are now well entering the exciting era of stem *** stem cell therapy holds great promise for the treatment of many diseases such as stroke,traumatic brain injury,Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral-sclerosis,myocardial infarction,muscular dystrophy,diabetes,and etc..It is generally believed that transplantation of specific stem cells into the injured tissue to replace the lost cells is an effective way to repair the *** fact,organ transplantation has been successfully practiced in clinics for liver or kidney ***,the severe shortage of donor organs has been a major obstacle for the expansion of organ transplantation *** that direction,generation of transplantable organs using stem cells is a desirable approach for organ replacement and would be of great interest for both basic and clinical *** we review recent progress in the field of organ generation using various methods including single adult tissue stem cells,a blastocyst complementation system,tissue decellularization/recellularization and a combination of stem cells and tissue engineering.

关键词： Stem cells functional organs Blastocyst complementation Decellularization Recellularization Tissue engineering

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Mannan oligosaccharides alleviate oxidative injury in the head kidney and spleen in grass carp(Ctenopharyngodon idella)via the Nrf2 signaling pathway after Aeromonas hydrophila infection

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1744-1758页

作者： Zhiyuan Lu Lin Feng Weidan Jiang Pei Wu Yang Liu Jun Jiang Shengyao Kuang Ling Tang Shuwei Li Chengbo Zhong Xiaoqiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Sichuan Agricultural UniversityChengdu 611130China Sichuan Animal Science Academy Sichuan Animtech Feed Co.LtdChengdu 610066China Animal Breeding and Genetics Key Laboratory of Sichuan Province Animal Nutrition InstituteSichuan Academy of Animal ScienceChengdu 610066China

Background Mannan oligosaccharides(MOS)are recommended as aquaculture additives owing to their excellent antioxidant *** the present study,we examined the effects of dietary MOS on the head kidney and spleen of grass carp(Ctenopharyngodon idella)with Aeromonas hydrophila *** A total of 540 grass carp were used for the *** were administered six gradient dosages of the MOS diet(0,200,400,600,800,and 1,000 mg/kg)for 60 ***,we performed a 14-day Aeromonas hydrophila challenge *** antioxidant capacity of the head kidney and spleen were examined using spectrophotometry,DNA fragmentation,qRT-PCR,and Western *** After infection with Aeromonas hydrophila,400-600 mg/kg MOS supplementation decreased the levels of reactive oxygen species,protein carbonyl,and malonaldehyde and increased the levels of anti-superoxide anion,antihydroxyl radical,and glutathione in the head kidney and spleen of grass *** activities of copper-zinc superoxide dismutase,manganese superoxide dismutase,catalase,glutathione S-transferase,glutathione reductase,and glutathione peroxidase were also enhanced by supplementation with 400-600 mg/kg ***,the expression of most antioxidant enzymes and their corresponding genes increased significantly with supplementation of 200-800 mg/kg *** and protein levels of nuclear factor erythroid 2-related factor 2 also increased following supplementation with 400-600 mg/kg *** addition,supplementation with 400-600 mg/kg MOS reduced excessive apoptosis by inhibiting the death receptor pathway and mitochondrial pathway *** Based on the quadratic regression analysis of the above biomarkers(reactive oxygen species,malondialdehyde,and protein carbonyl)of oxidative damage in the head kidney and spleen of on-growing grass carp,the recommended MOS supplementation is 575.21,557.58,531.86,597.35,570.16,and 553.80 mg/kg,***,MOS supplementation could allev

关键词： Antioxidant Apoptosis functional organs Grass carp Mannan oligosaccharides

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