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Resting-State functional connectivity of the Hippocampus in Suicide Ideal Patients with Major Depressive Disorder

神经药理学报 2019年第4期 19-20页

作者： HE Can-can GONG Liang XIE Chun-ming ZHANG Zhi-jun Department of Neurology Affiliated ZhongDa HospitalSchool of MedicineSoutheast University Department of Psychology Affiliated ZhongDa HospitalSchool of MedicineSoutheast University

Objective:Suicide is highly-prevalent and the most serious outcome in major depressive disorder（ MDD）,yet the disturbances in neural functional system that confer suiciderisk remain obscure. In this study,we seek to investigate the neural functional differences between healthy participants with suicidal ideal（ SI） MDD patients. Methods:Seventy-seven healthy controls（ HC） and 124 well-matched MDD patients with different degrees of SI were recruited. Based on suicide factors of 17-items Hamilton Depression Scale（ HAMD-17）,We divided MDD patients into four groups,MDD;（ n=55）,MDD patients without SI;MDD;（ n=41）,MDD patients with mild SI,MDD;（ n=20）,MDD patients with moderate SI,MDD;（ n=8）,MDD patients with severe SI. Bilateral hippocampus were selected to construct hippocampus memory functional connectivity networks（ HFCN）. One-way ANCOVA was applied to investigate the difference in HFCN between different level of SI patients with MDD and HC. Furthermore,the correlation analyses were conducted to identify the correlation between HFCN and HAMD-17 scores in the SI groups. Results:Compared with CN subjects,MDD patients showed severer SI. We found significant group differences on the bilateral HFCN in bilateral supramarginal gyrus（SMG）,right middle prefrontal cortex（ mPFC）,orbital frontal cortex（ OFC）,angular cortex,as well as left middle temporal gyrus（ MTG）,superior parietal gyrus（ SPG）,and precuneus. Interestingly,an inverted U-shaped modulation was showed in the right mPFC（ control system）,right IPG,left SPG and SMG,while U-shaped modulations were found in the right hippocampus. The correlation analysis showed a significant correlation between the HAMD-17 scores and functional connectivity of the right hippocampus with the right mPFC area in the SI groups（r=-2.12,P=0.018）. Conclusion:Our study manifested a nonlinear modulation of interacting between suicide ideal and depression on brain function. These findings expand our understanding of the functional neural basis of different level of SI in MDD patients and will h

关键词： major depressive disorder suicide ideal hippocampus neural circuit functional connectivity

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精准功能磁共振成像揭示个体化脑功能网络组织

心理学

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心理学 2024年第3期

作者：周广方金花

精准功能磁共振成像(precision functional magnetic resonance imaging，pfMRI)是指在单个个体中收集大量fMRI数据的一种数据采集策略，相较于传统fMRI研究中针对每个被试采集少量数据，之后通过组平均揭示认知过程的脑功能规律或是特... 详细信息

精准功能磁共振成像(precision functional magnetic resonance imaging，pfMRI)是指在单个个体中收集大量fMRI数据的一种数据采集策略，相较于传统fMRI研究中针对每个被试采集少量数据，之后通过组平均揭示认知过程的脑功能规律或是特定人群共享的脑功能特征的方法，该方法的优势在于能够揭示每个个体的大脑特征，因此日益受到研究者的重视和应用。迄今为止，众多研究采用该方法从功能网络组织的个体差异、个体识别、局部区域的功能定位、个体网络枢纽的识别、个体功能网络的发展与可塑性和临床应用六个角度系统揭示了个体化的脑功能网络组织，这些研究成果对未来脑科学研究具有重要启发。未来研究应该重点探讨现有研究所揭示的个体功能网络组织特点与行为表现的关系，通过对数据分析和成像技术的改进减少该方法所需的扫描时间，并尝试将该方法应用到任务态fMRI和多模态数据的融合研究中。

关键词：精准功能磁共振成像脑功能网络个体差异功能连接 precision functional magnetic resonance imaging brain functional network individual difference functional connectivity

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functional connectivity of spikes in medial prefrontal cortex during rat working memory task via sparse factorization

Functional connectivity of spikes in medial prefrontal corte...

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中国神经科学学会第十届全国学术会议

作者： Jing Wei Xin Tian Laboratory of Neural Engineering School of Biomedical EngineeringTianjin Medical University

Objective Working memory is one of the important cognitive functions.The question addressed here is how the neuronal signals interact during working memory.Multi-spike series,with high spatial and temporal resolution,were chose to investigate the connectivity among neuronal signals during working memory.Non-negative matrix factorization（NMF） was used for multi-spike series in order to extract the intrinsic feature from the original data.Methods Multi-spike series were recorded from Sprague-Dawley rats with implanted 16-channel microelectrode arrays in medial prefrontal cortex（mPFC） when the rats performed the working memory task（10 correct trials） on the Y-maze.The discrete multi-spike series were transformed to continuous multi-spike series for further analysis via instantaneous firing rate.Subsequendy,the continuous multi-spike series（defined as original series） were decomposed into encoding matrix（defined as NMF components） and basis matrix by NMF.The functional connectivity of the NMF components and original series was assessed using the Granger causal connectivity analysis（GCCA） and complex network analysis,respectively.Then Granger causality matrices and quantitative measures（causal density and global efficiency） were obtained.Results The causal density and global efficiency of both groups all peaked before the event time.However,almost all values of NMF components were significantly higher than that of original series,especially at the peak points.Conclusion The functional connectivity of multi-spikes was enhanced during the working memory task.The NMF method could lead to improved identification about mPFC functional connectivity during working memory task.

关键词： working memory non-negative matrix factorization rat medial prefrontal cortex functional connectivity

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The Brain Connectome for Chinese Reading

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Neuroscience Bulletin 2022年第9期38卷 1097-1113页

作者： Wanwan Guo Shujie Geng Miao Cao Jianfeng Feng Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghai200433China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Ministry of Education) Fudan UniversityShanghai200433China

Chinese,as a logographic language,fundamentally differs from alphabetic languages like English.Previous neuroimaging studies have mainly focused on alphabetic languages,while the exploration of Chinese reading is still an emerging and fast-growing research field.Recently,a growing number of neuroimaging studies have explored the neural circuit of Chinese reading.Here,we summarize previous research on Chinese reading from a connectomic perspective.Converging evidence indicates that the left middle frontal gyrus is a specialized hub region that connects the ventral with dorsal pathways for Chinese reading.Notably,the orthography-to-phonology and orthography-to-semantics mapping,mainly processed in the ventral pathway,are more specific during Chinese reading.Besides,in addition to the left-lateralized language-related regions,reading pathways in the right hemisphere also play an important role in Chinese reading.Throughout,we comprehensively review prior findings and emphasize several challenging issues to be explored in future work.

关键词： Brain connectome Chinese reading Word recognition Reading comprehension Structural connectivity functional connectivity

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Neuroscience Bulletin 2022年第10期38卷 1215-1228页

作者： Liwei Sun Wenjing Zhang Mengyue Wang Songjian Wang Zhen Li Cui Zhao Meng Lin Qian Si Xia Li Ying Liang Jing Wei Xu Zhang Renji Chen Chunlin Li School of Biomedical Engineering Capital Medical UniversityBeijing100069China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Capital Medical UniversityBeijing100069China Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application School of Biomedical EngineeringCapital Medical UniversityBeijing100069China Beijing Stomatological Hospital Capital Medical UniversityBeijing100050China School of Life Science Beijing Institute of TechnologyBeijing100081China Beijing Institute of Otolaryngology-Head and Neck Surgery Beijing100005China Key Laboratory of Otolaryngology-Head and Neck Surgery(Capital Medical University) Ministry of EducationBeijing100005China Beijing Tongren Hospital Capital Medical UniversityBeijing100005China Department of Ultrasound Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing100026China Peking University First Hospital Beijing100034China

Cleft lip and/or palate(CLP)are the most common craniofacial malformations in humans.Speech problems often persist even after cleft repair,such that follow-up articulation training is usually required.However,the neural mechanism behind effective articulation training remains largely unknown.We used fMRI to investigate the differences in brain activation,functional connectivity,and effective connectivity across CLP patients with and without articulation training and matched normal participants.We found that training promoted task-related brain activation among the articulation-related brain networks,as well as the global attributes and nodal efficiency in the functional-connectivity-based graph of the network.Our results reveal the neural correlates of effective articulation training in CLP patients,and this could contribute to the future improvement of the post-repair articulation training program.

关键词： Non-syndromic cleft lip and palate Articulation training fMRI functional connectivity Graph-based network analysis

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Preoperative Acute Sleep Deprivation Causes Postoperative Pain Hypersensitivity and Abnormal Cerebral Function

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Neuroscience Bulletin 2022年第12期38卷 1491-1507页

作者： Meimei Guo Yuxiang Wu Danhao Zheng Lei Chen Bingrui Xiong Jinfeng Wu Ke Li Li Wang Kangguang Lin Zongze Zhang Anne Manyande Fuqiang Xu Jie Wang Mian Peng Department of Anesthesiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health and Kinesiology School of Physical EducationJianghan UniversityWuhan 430056China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China Department of Anesthesiology Peking University Third HospitalBeijing 100191China Department of Afective Disorders The Afliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Human and Social Sciences University of West LondonLondon W1S 3PRUK Institute of Neuroscience and Brain Disease Xiangyang Central HospitalAfliated Hospital of Hubei University of Arts and ScienceXiangyang 441000China University of Chinese Academy of Sciences Beijing 100049China

Preoperative sleep loss can amplify post-operative mechanical hyperalgesia.However,the underlying mechanisms are still largely unknown.In the current study,rats were randomly allocated to a control group and an acute sleep deprivation(ASD)group which experienced 6 h ASD before surgery.Then the variations in cerebral function and activity were investigated with multi-modal techniques,such as nuclear magnetic resonance,functional magnetic resonance imaging,c-Fos immunofluorescence,and electrophysiology.The results indicated that ASD induced hyperalgesia,and the metabolic kinetics were remarkably decreased in the striatum and midbrain.The functional connectivity(FC)between the nucleus accumbens(NAc,a subregion of the ventral striatum)and the ventrolateral periaqueductal gray(vLPAG)was significantly reduced,and the c-Fos expression in the NAc and the vLPAG was suppressed.Furthermore,the electrophysiological recordings demonstrated that both the neuronal activity in the NAc and the vLPAG,and the coherence of the NAc-vLPAG were suppressed in both resting and task states.This study showed that neuronal activity in the NAc and the vLPAG were weakened and the FC between the NAc and the vLPAG was also suppressed in rats with ASD-induced hyperalgesia.This study highlights the importance of preoperative sleep management for surgical patients.

关键词： Acute sleep deprivation Incisional pain Nucleus accumbens Periaqueductal gray functional connectivity

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Neural Regeneration Research 2023年第9期18卷 1968-1975页

作者： He-Mei Huang Gui-Sheng Chen Zhong-Yi Liu Qing-Lin Meng Jia-Hong Li Han-Wen Dong Yu-Chen Chen Fei Zhao Xiao-Wu Tang Jin-Liang Gao Xi-Ming Chen Yue-Xin Cai Yi-Qing Zheng Department of Otolaryngology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Institute of Hearing and Speech-Language Science Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Otolaryngology Shenzhen-Shanwei Central HospitalSun Yat-sen Memorial HospitalSun Yat-sen UniversityShanweiGuangdong ProvinceChina Department of Radiology Guangdong Provincial Work Injury Rehabilitation HospitalGuangzhouGuangdong ProvinceChina Acoustics Lab of School of Physics and Optoelectronics and State Key Laboratory of Subtropical Building Science South China University of TechnologyGuangzhouGuangdong ProvinceChina Department of Radiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Speech and Language Therapy and Hearing Science Cardiff Metropolitan UniversityCardiffUK Department of Otolaryngology Shenzhen Baoan Maternal and Child Health HospitalShenzhenGuangdong ProvinceChina

Patients with age-related hearing loss face hearing difficulties in daily life.The causes of age-related hearing loss are complex and include changes in peripheral hearing,central processing,and cognitive-related abilities.Furthermore,the factors by which aging relates to hearing loss via changes in audito ry processing ability are still unclear.In this cross-sectional study,we evaluated 27 older adults(over 60 years old) with age-related hearing loss,21 older adults(over 60years old) with normal hearing,and 30 younger subjects(18-30 years old) with normal hearing.We used the outcome of the uppe r-threshold test,including the time-compressed thres h old and the speech recognition threshold in noisy conditions,as a behavioral indicator of auditory processing ability.We also used electroencephalogra p hy to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state.The timecompressed threshold and speech recognition threshold data indicated significant diffe rences among the groups.In patients with age-related hearing loss,information masking(babble noise) had a greater effect than energy masking(speech-shaped noise) on processing difficulties.In terms of resting-state electroencephalography signals,we observed enhanced fro ntal lobe(Brodmann’s area,BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing,and greater activation in the parietal(BA7) and occipital(BA19) lobes in the individuals with age-related hearing loss compared with the younger adults.Our functional connection analysis suggested that compared with younger people,the older adults with normal hearing exhibited enhanced connections among networks,including the default mode network,sensorimotor network,cingulo-opercular network,occipital network,and frontoparietal network.These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced audito ry processing capabilities and t

关键词： age-related hearing loss aging electroencephalography fast-speech comprehension functional brain network functional connectivity restingstate sLORETA source analysis speech reception threshold

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Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

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Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the cortex.However,most studies are volume-based which may lead to inaccurate anatomical positioning of functional data.The methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity study.In this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this study.Data of resting-state functional magnetic resonance imaging were collected.The results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory cortex.Regions showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of interests.Seed-based functional connectivity was performed to investigate interregional functional synchronization.When the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital cortex.Compared with healthy controls,patients with ONFH showed

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

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Acupuncture enhances brain function in patients with mild cognitive impairment: evidence from a functional-near infrared spectroscopy study

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Neural Regeneration Research 2022年第8期17卷 1850-1856页

作者： M.N.Afzal Khan Usman Ghafoor Ho-Ryong Yoo Keum-Shik Hong School of Mechanical Engineering Pusan National UniversityBusanKorea Department of Neurology Disorders Dunsan HospitalDaejeon UniversityDaejeonKorea

Mild cognitive impairment(MCI)is a precursor to Alzheimer’s disease.It is imperative to develop a proper treatment for this neurological disease in the aging society.This observational study investigated the effects of acupuncture therapy on MCI patients.Eleven healthy individuals and eleven MCI patients were recruited for this study.Oxy-and deoxy-hemoglobin signals in the prefrontal cortex during working-memory tasks were monitored using functional near-infrared spectroscopy.Before acupuncture treatment,working-memory experiments were conducted for healthy control(HC)and MCI groups(MCI-0),followed by 24 sessions of acupuncture for the MCI group.The acupuncture sessions were initially carried out for 6 weeks(two sessions per week),after which experiments were performed again on the MCI group(MCI-1).This was followed by another set of acupuncture sessions that also lasted for 6 weeks,after which the experiments were repeated on the MCI group(MCI-2).Statistical analyses of the signals and classifications based on activation maps as well as temporal features were performed.The highest classification accuracies obtained using binary connectivity maps were 85.7%HC vs.MCI-0,69.5%HC vs.MCI-1,and 61.69%HC vs.MCI-2.The classification accuracies using the temporal features mean from 5 seconds to 28 seconds and maximum(i.e,max(5:28 seconds))values were 60.6%HC vs.MCI-0,56.9%HC vs.MCI-1,and 56.4%HC vs.MCI-2.The results reveal that there was a change in the temporal characteristics of the hemodynamic response of MCI patients due to acupuncture.This was reflected by a reduction in the classification accuracy after the therapy,indicating that the patients’brain responses improved and became comparable to those of healthy subjects.A similar trend was reflected in the classification using the image feature.These results indicate that acupuncture can be used for the treatment of MCI patients.

关键词： acupuncture Alzheimer’s disease cognition convolutional neural network functional connectivity functional-near infrared spectroscopy hemodynamic response linear discriminant analysis mild cognitive impairment

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Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal-frontoparietal networks in patients with advanced Alzheimer’s disease

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Translational Neurodegeneration 2022年第1期11卷 148-160页

作者： Yin Jiang Tian-Shuo Yuan Ying-Chuan Chen Peng Guo Teng-Hong Lian Yu-Ye Liu Wei Liu Yu-Tong Bai Quan Zhang Wei Zhang Jian-Guo Zhang Department of functional Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of functional Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Center for Cognitive Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Beijing Key Laboratory of Neurostimulation Beijing 100070China.

Background:Deep brain stimulation(DBS)of the nucleus basalis of Meynert(NBM)has shown potential for the treatment of mild-to-moderate Alzheimer’s disease(AD).However,there is little evidence of whether NBM-DBS can improve cognitive functioning in patients with advanced AD.In addition,the mechanisms underlying the modulation of brain networks remain unclear.This study was aimed to assess the cognitive function and the resting-state connectivity following NBM-DBS in patients with advanced AD.Methods:Eight patients with advanced AD underwent bilateral NBM-DBS and were followed up for 12 months.Clinical outcomes were assessed by neuropsychological examinations using the Mini-Mental State Examination(MMSE)and Alzheimer’s Disease Assessment Scale.Resting-state functional magnetic resonance imaging and positron emis-sion tomography data were also collected.Results:The cognitive functioning of AD patients did not change from baseline to the 12-month follow-up.Interestingly,the MMSE score indicated clinical efficacy at 1 month of follow-up.At this time point,the connectivity between the hippocampal network and frontoparietal network tended to increase in the DBS-on state compared to the DBS-off state.Additionally,the increased functional connectivity between the parahippocampal gyrus(PHG)and the parietal cortex was associated with cognitive improvement.Further dynamic functional network analysis showed that NBM-DBS increased the proportion of the PHG-related connections,which was related to improved cognitive performance.Conclusion:The results indicated that NBM-DBS improves short-term cognitive performance in patients with advanced AD,which may be related to the modulation of multi-network connectivity patterns,and the hippocampus plays an important role within these networks.

关键词： Alzheimer’s disease Deep brain stimulation Nucleus basalis of Meynert Hippocampal Frontoparietal functional connectivity

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