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Asian Journal of Andrology 2021年第1期23卷 74-79页

作者： Se Young Choi Byung Hoon Chi Tae-Hyoung Kim Bumjin Lim Wonchul Lee Dalsan You Choung-Soo Kim Department of Urology Chung-Ang University HospitalChung-Ang University College of MedicineDongjak-guSeoul 06973Korea Department of Urology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea

We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate *** study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral *** frozen sections of the periurethra,dorsal vein,and bladder neck were *** ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic *** 271 patients,108(39.9%)had PSM and 163(60.1%)had negative *** Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,Pfrozen sections had a sensitivity of 83.3%and a specificity of 84.2%in detecting PSM with Gleason pattern≥*** analysis showed that membranous urethra length(odds ratio[OR]:0.79,P=0.0376)and extracapsular extension of the apex(OR:4.58,P=0.0226)on magnetic resonance imaging(MRI)and positive periurethral tissue(OR:17.85,Pfrozen sections of periurethral tissue can independently predict PSM,whereas sections of the bladder neck and dorsal vein could *** examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.

关键词： biochemical recurrence frozen section positive surgical margin robotic-assisted prostatectomy

Intra-operative frozen section diagnosis of breast lesions:a retrospective analysis of 13 243 Chinese patients

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Chinese Medical Journal 2007年第8期120卷 630-635页

作者： NIU Yun FU Xi-lin YU Yong Peizhong Peter Wang CAO Xu-chen Breast Cancer Pathological Department and Research Laboratory Breast Cancer Research Key laboratory of National Education Ministry Tianjin Cancer Institute Tianjin Medical University Tianjin 300060 China Epidemical and Bio-statistic Department Breast Cancer Research Key laboratory of National Education Ministry Tianjin Cancer Institute Tianjin Medical University Tianjin 300060 China Breast Cancer Surgical Department Breast Cancer Research Key laboratory of National Education Ministry Tianjin Cancer Institute Tianjin Medical University Tianjin 300060 China Division of Community Health Faculty of Medicine Memorial University of Newfoundland St. John＇s NL Canada

Background Although cytological methods for breast oncology have been used in recent decades, intra-operative frozen section has been playing a vital role in making therapeutic decisions. We analyzed a large series of frozen section diagnoses for Chinese cases of breast lesion within the last 15 years. The experience was expected to increase the diagnostic accuracy of cases with breast lesions. Methods The data from consecutive 13243 cases of breast lesions diagnosed with intra-operative frozen sections between 1988 to 2002 were compared with paraffin sections in a case by case manner. The causes of false negative and positive diagnoses as well as delayed diagnoses were analyzed. Results One hundred and seventeen cases （0.9%） were falsely diagnosed, with one false positive case and 116 false negative cases. The diagnosis of 47 cases （0.4%） was delayed. The proportion of several lesions had the features of the patients＇ ages. Six types （false invasion, peri-papUloma, adenoma of nipple duct, florid adenosis, sclerosing adenosis, and granulose cell tumor） of lesions may lead to false positive, and four types （morphological changes responding chemotherapy, well differentiated papillary carcinoma, invasive Iobular carcinoma, and tubular carcinoma） to a false negative. Gross and microscopic findings may be inconsistent in two types of lesions （radial scar and florid adenosis） microscopic and clinical findings in three types （ganulomatous mastitis mammary, duct ectasia, and fat necrosis）, and three types （abundant fat or sclerous tissues; borderline lesions and changes of post-chemotherapy） were likely wrongly classified. Conclusions Intra-operative frozen section can accurately identify breast lesions in many instances, leading to fewer errors on account of more diaanostic experience and understandina of diaanostic limitations.

关键词： breast neoplasm frozen section differential diagnosis

Retrospective evaluation of frozen section use for thyroid nodules with a prior fine needle aspiration diagnosis of Bethesda Ⅱ-Ⅵ: The Weill Cornell Medical College experience

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2015年第1期1卷 -页

作者： Marc A.Cohen Krupa R.Patel Jonathan Gromis David I.Kutler William I.Kuhel Brian J.Stater Aaron Schulman Department of Otolaryngology-Head and Neck Surgery New York Presbyterian Hospital/Weill Cornell Medical Center New York NY 10065 USA Weill Cornell Medical College New York NY 10065 USA Department of Endocrinology New York Presbyterian Hospital/Weill Cornell Medical CenterNew York NY 10065 USA

Objective: To evaluate the Weill Cornell Medical CoLlege (WCMC)/New York Presbyterian Hospital (NYPH) experience with intraoperative frozen (IOF) section in the management of thyroid nodules with a fine needle aspiration (FNA) diagnosis of Bethesda Ⅱ-Ⅵ and to analyze the cost and pathology benefit it ***: The surgical and cytopathology files at WCMC/NYPH were searched within the time period of January 2008 to May 2013.A total of 435 thyroid specimens were identified for which both an FNA and subsequent IOF section was *** FNA was correlated with the locations of the resected nodule and the nodule frozen for intraoperative *** results of the FNA were compared to the IOF section diagnosis and final diagnosis (FD).Results: Among 435 cases, the FNA diagnosis was Bethesda Ⅱ:149 cases, Bethesda Ⅲ:170 cases, Bethesda Ⅳ: 91 cases, Bethesda Ⅴ: 19 cases, and Bethesda Ⅵ: 6 *** were a total of 83 carcinomas identified on FD, which included 69 papillary thyroid carcinomas (PTCs), 12 follicular carcinomas, and 2 poorly differentiated *** preoperative FNA diagnosis for these carcinomas was as follows: Bethesda Ⅱ, 11/149 (7.4％), Bethesda Ⅲ, 24/170 (14％), Bethesda Ⅳ, 26/91 (29％), Bethesda Ⅴ, 16/19 (84％), and Bethesda Ⅵ, 6/6 (100％).IOF section contributed to the diagnosis of malignancy in 16/429 (4％) cases: 1/149 (0.7％) Bethesda Ⅱ, 5/170 (3％) Bethesda Ⅲ, 2/91 (1.1％) Bethesda Ⅳ, and 8/19 (42％) Bethesda Ⅴ.The diagnosis of malignancy was confirmed in the 6 Bethesda Ⅵl cases by IOF *** were no false positives on IOF *** had a sensitivity and specificity of 26％ and 100％, ***: The role of IOF section is limited in the evaluation of thyroid *** section is most useful for nodules with an FNA diagnosis of Bethesda V *** diagnosis of follicular variant of PTC remains difficult on frozen section.

关键词： Thyroid Nodule frozen section Fine-needle aspiration Sensitivity Specificity

Comparison between peritoneal tuberculosis and primary peritoneal carcinoma： a 16-year, single-center experience

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Chinese Medical Journal 2012年第18期125卷 3256-3260页

作者： WANG Dan ZHANG Jun-ji HUANG Hui-fang SHEN Keng CUI Quan-cai XIANG Yang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academyof Medical Sciences and Peking Union Medical College China Beijing100730 Department of-Pathology Peking Union Medical College Hospital Chinese Academyof Medical Sciences and Peking Union Medical College China Beijing100730

Background Peritoneal tuberculosis and primary peritoneal carcinoma can both present as an abdominal mass and ascites with elevated serum CA125. The purpose of our study was to evaluate the clinical features of peritoneal tuberculosis, compare them with features of primary peritoneal carcinoma, and establish definitive diagnostic procedures. Methods We conducted a retrospective study in patients with peritoneal tuberculosis from January 1995 to October 2010 at Peking Union Medical College Hospital. During this time, the data of 38 patients with primary peritoneal carcinoma were reviewed. Results The median age was 34 years （range, 19-80 years）. The most common symptoms were abdominal distension （16/30, 53.3%） and an abdominal mass （12/30, 40.0%）. The serum CA125 level was elevated in 25 patients （83.3%）. The median level of cancer antigen CA125 was 392.5 U/ml （range, 0.6-850.0 U/ml）. Abdominal ultrasound revealed a pelvic mass in 25 patients and ascites in 20 patients. Diagnostic laparoscopy was performed in 15 patients （50.0%） and exploratory laparotomy was performed in 12 patients （40.0%）, and 3 patients （10.0%） who underwent laparoscopy converted to laparotomy because of severe adhesions. The intraoperative findings were adhesions, multiple white tubercles, and ascites. frozen tissue sections were obtained in 17 patients, and 14 of whom showed chronic granulomatous reactions. Final pathological examinations confirmed the diagnosis. Conclusions Peritoneal tuberculosis should be considered as a differential diagnosis, especially for young women with an abdominal mass, ascites, and elevated serum CA125 levels. Laparoscopy is a useful diagnostic method for peritoneal tuberculosis, and intraoperative frozen sections are recommended when the diagnosis is in doubt.

关键词： peritoneal tuberculosis primary peritoneal carcinoma, laparoscopy frozen section

Clinical Diagnosis Technique of Goat Pox Disease

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Agricultural Science & Technology 2010年第7期11卷 91-93页

作者：刘俊伟张海棠王飞陈俊杰司红英河南科技学院动物科学学院河南新乡453003 商丘市动物疫病防控中心河南商丘476000

[Objective] The aim was to provide theoretical basis for effective prevention of goat pox disease.[Method] 5 cases of infected goats were diagnosed for goat pox with microbiology *** poxes on their skin,rumen,reticulum,omasum,abomasum and submandibular lymph nodes,bronchial lymph nodes,lung and spleen were macroscopically and microscopically observed with pathanatomical and histopathological technique.[Result] Poxes on skin mainly showed ashen hemisphere state and gave prominence to the surface of skin; some cases had hemorrhage in the poxes and showed dark purplish *** on gastric mucosa showed *** inclusion body could be all observed in epithelial cells of the poxes and macrphages of lymph node,lung and spleen.[Conclusion] Poxes on skin,lung and the surface of gastric mucosa as well as cytoplasmic inclusion body in the epithelial cells of pox and the macrphages of lymphoid organs were the especial pathochanges of goat pox,which could be taken as the proof of goat pox＇s clinic diagnisis.

关键词： Goat pox Clinic diagnisis Pathoanatomy frozen section Cytoplasmic inclusion body

Histological Characteristics of Hair Follicle Structure of Hezuo Swine from Gansu Province

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Agricultural Science & Technology 2012年第9期13卷 1955-1957页

作者：汪磊刘燕飞甘肃省天祝县畜牧技术推广站甘肃天祝733200 甘肃省家畜繁育中心甘肃武威733000

The characteristics of skin hair follicle structure of Hezuo swine were in- vestigated using frozen section method and HE staining. Experimental results showed that the hair root, hair tip, outer sheath, inner sheath, hair follicle group, fi- brous sheath, outer epidermis, inner epidermis, sebaceous gland and other organiza- tional structures of hair follicles of Hezuo swine can be clearly observed. The hair follicle pore size varied extremely significantly （P〈0.01） among different parts, showing a downward trend of shoulder 〈 body side 〈 buttocks; the hair follicle density ranged from 5.59 to 7.26 hair follicles/mm^2. This study provides reference for the in-dustrial and medical applications.

关键词： Hezuo swine Hair follicles frozen section HE staining

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苦杏仁防肝癌的调查初报

苏州医学院学报 1994年第3期14卷 219-219页

作者：薛万程上海医科大学附属肿瘤医院

苦杏仁防肝癌的调查初报上海医科大学附属肿瘤医院薛万程江苏省启东为肝癌高发区。１９７４年我们调查时发现，该区中有杏树与白果树的乡的发病率最低，设想这可能与空气中苦杏仁苷有关。初步报道于下一、根据《启东县１９７２年肝癌分... 详细信息

苦杏仁防肝癌的调查初报上海医科大学附属肿瘤医院薛万程江苏省启东为肝癌高发区。１９７４年我们调查时发现，该区中有杏树与白果树的乡的发病率最低，设想这可能与空气中苦杏仁苷有关。初步报道于下一、根据《启东县１９７２年肝癌分布图》（由启东肝癌防治研究领导小组...

关键词： PDR frozen section diagnosis