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Glutamine synthetase activity and glutamate uptake in hippocampus and frontal cortex in portal hypertensive rats

World Journal of Gastroenterology 2009年第23期15卷 2893-2899页

作者： Gabriela Beatriz Acosta María Alejandra Fernández Diego Martín Roselló María Luján Tomaro Karina Balestrasse Abraham Lemberg Institute of Pharmacological Research (ININFA) National Research Council of Argentina (CONICET) and University of Buenos Aires Junín 956. 5th floor C1113AAD Buenos Aires Argentina Laboratory of Portal Hypertension School of Pharmacy and Biochemistry University of Buenos Aires Junín 956. 5th floor C1113AAD Buenos Aires Argentina Department of Biological Chemistry School of Pharmacy and Biochemistry University of Buenos Aires Junín 596. 5th floor C1113AAD Buenos Aires Argentina

AIM: To study glutamine synthetase (GS) activity and glutamate uptake in the hippocampus and frontal cortex (FC) from rats with prehepatic portal vein hypertension. METHODS: Male Wistar rats were divided into shamoperated group and a portal hypertension (PH) group with a regulated stricture of the portal vein. Animals were sacrificed by decapitation 14 d after portal vein stricture. GS activity was determined in the hippocampus and FC. Specific uptake of radiolabeled L-glutamate was studied using synaptosome-enriched fractions that were freshly prepared from both brain areas. RESULTS: We observed that the activity of GS increased in the hippocampus of PH rats, as compared to control animals, and decreased in the FC. A significant decrease in glutamate uptake was found in both brain areas, and was more marked in the hippocampus. The decrease in glutamate uptake might have been caused by a deficient transport function, signif icantly and persistent increase in this excitatory neurotransmitter activity. CONCLUSION: The presence of moderate ammonia blood levels may add to the toxicity of excitotoxic glutamate in the brain, which causes alterations in brain function. Portal vein stricture that causes portal hypertension modif ies the normal function in some brain regions.

关键词： Portal hypertension Glutamine synthetase Glutamate uptake frontal cerebral cortex Hippocampus Rat

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