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The phenotype and activation status of regulatory T cells during friend retrovirus infection

Virologica Sinica 2014年第1期29卷 48-60页

作者： Jara J.Joedicke Kirsten K.Dietze Gennadiy Zelinskyy Ulf Dittmer Institute for Virology University Hospital EssenUniversity of Duisburg-Essen

The suppressive capacity of regulatory T cells （Tregs） has been extensively studied and is well established for many *** expansion,accumulation,and activation of Tregs in viral infections are of major interest in order to find ways to alter Treg functions for therapeutic *** are able to dampen effector T cell responses to viral infections and thereby contribute to the establishment of a chronic *** the friend retrovirus （FV） mouse model,Tregs are known to expand in all infected *** better understand the characteristics of these Treg populations,their phenotype was analyzed in *** acute FV-infection,Tregs became activated in the spleen and bone marrow,as indicated by various T cell activation markers,such as CD43 and ***,Tregs in the bone marrow,which contains the highest viral loads during acute infection,displayed greater levels of activation than Tregs from the *** expansion was driven by proliferation but no FV-specific Tregs could be *** Tregs in FV-infection did not produce Granzyme B （GzmB） or tumor necrosis factor α （TNFα）,which are thought to be a potential mechanism for their suppressive ***,Tregs expressed inhibitory markers,such as TIM3,PD-1 and *** TIM3 and PD-L1 with antibodies during chronic FV-infection increased the numbers of activated *** data may have important implications for the understanding of Treg functions during chronic viral infections.

关键词： regulatory T cells friend retrovirus Vβ5+ Treg activation marker

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