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fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma

World Journal of Gastroenterology 2010年第44期16卷 5603-5610页

作者： Yoshito Tomimaru Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Takehiro Noda Koji Umeshita Yuichiro Doki Masaki Mori Hiroak Nagano Department of Surgery Graduate School of Medicine Osaka University Division of Health Sciences Graduate School of MedicineOsaka University

AIM:To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function,postoperative complications and cancer ***:We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993,Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006,Group B),and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)].Additionally,only in limited patients in Group B1 and Group B2 with intraoperative blood loss≥ 2000 mL (Group B1 ≥ 2000 mL and Group B2 ≥ 2000 mL),postoperative complications,liver function tests,and cancer prognosis were ***:No mortality was registered in Group B,compared to 8 patients (3.9%) of Group *** incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)].The incidence of complications and postoperative liver function tests were comparable between Group B1 ≥ 2000 mL vs Group B2 ≥ 2000 *** prognosis did not correlate with administration of FFP,but with tumor-related ***:The outcome of hepatectomy for HCC is not influenced by FFP *** suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC.

关键词： fresh frozen plasma Hepatocellular carcinoma Surgery Transfusion

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Application of fresh frozen plasma transfusion in the management of excessive warfarin-associated anticoagulation

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Blood Science 2022年第2期4卷 57-64页

作者： Yuanyuan Luo Chunya Ma Yang Yu Department of Transfusion Medicine First Medical Center of PLA General HospitalBeijingP.R.China

Warfarin is a commonly used oral *** with artificial valve replacement,atrial fibrillation,pulmonary embolism,deep vein thrombosis,and other diseases require long-term anticoagulant oral treatment with *** warfarin exhibits prompt action with long maintenance time,it has become a key drug for the treatment of patients at risk of developing thrombosis or *** is a bican coumarin anticoagulant,that exhibits competitive action against vitamin K as its mechanism of action,thereby inhibiting the synthesis of coagulation factors—predominantly the vitamin K-dependent coagulation factors II,VII,IX,and X—in ***-term warfarin is known to significantly increase the risk of organ bleeding in some patients,while some patients may need to reverse the anticoagulation *** instance,patients scheduled for emergency or invasive surgery may require rapid anticoagulation *** such medical circumstances,fresh frozen plasma(FFP)is clinically used for the reversal of excess warfarin-associated anticoagulation,as it contains all the coagulation factors that can alleviate the abnormal blood anticoagulation status in such ***,this article aims to perform an in-depth review of relevant literature on the reversal of warfarin with FFP,and insightful deliberation of the application and efficacy of this clinical intervention.

关键词： Anticoagulation reversal fresh frozen plasma Warfarin

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fresh frozen plasma for the Treatment of a Chinese Patient with Hereditary Angioedema

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Chinese Medical Sciences Journal 2009年第4期24卷 246-247页

作者： Rui Tang Hong-yu Zhang Jia Gan Department of Allergy Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

HEREDITARY angioedema （HAE） is an autosomal dominant inherited condition which was initially described by Osier in 1888.1 Patients with HAE can develop rapid subcutaneous or submucosal edema involving the hands, feet, limbs, face, intestinal tract, even larynx and trachea. The mortality of an acute attack of HAE without treatment was reported as high as 30%.2 HAE is caused by the deficiency of Cl esterase inhibitor （CIINH） which results in episodes of edema in parts of the human body,

关键词： fresh frozen plasma hereditary angioedema treatment

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fresh frozen plasma for the Treatment of Hereditary Angioedema Acute Attacks

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Chinese Medical Sciences Journal 2012年第2期27卷 92-95页

作者： Rui Tang Shi Chen Hong-yu Zhang Department of Allergy Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Departrnent of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To determine the safety and efficacy of fresh frozen plasma （FFP） iniusion for the treat- ment of hereditary angioedema （FIAE）. Methods The medical records of patients with HAE admitted to Peking Union Medical College Fiospital who had received FFP infusion during 2004 and 2010 were reviewed and PubMed database iFom 1966 to the present were searched using the following key words： hereditary angioedema and fresh frozen plasma. The patient＇s age, sex, body location of HAE attacks, the dose of FFP infusion, time of beginning to improvenaent, time to complete remission, complication, C 1 inhibitor activity, and outcome were analyzed. Results A total of 13 enrolled patients （7 male and 6 female） received 16 times of FFP infusion, in- cluding 2 patients undergoing FFP infusion in Peking Union Medical College Hospital and 11 patients re- ported in the literature. The mean dosage of FFP infusion was 586±337 mL. Two cases suffered from wors- ening abdominal pain and one case experienced skin rash. Only I patient had no improvement in symptom owing to transfusion related reaction. There was a definite improvement in symptom 49± 19 minutes after beginning FFP infusion. The remission time decreased from 61.7±27.0 hours to 3.3 （2.0, 12.0） hours after FFP infusion. FFP infusion was effective for both type I and type Ⅱ HAE. Conclusion FFP seems to be safe and effective for acute attacks of HAE.

关键词： hereditary angioedema acute attacks fresh frozen plasma treatment

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Early goal-directed fluid therapy with fresh frozen plasma reduces severe acute pancreatitis mortality in the intensive care unit

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Chinese Medical Journal 2013年第10期126卷 1987-1988页

作者： WANG Ming-deng JI Yuan XU Jun JIANG Dong-hui LUO Liang HUANG Shun-wei Department of Intensive Care Unit Wuxi Second People's HospitalWuxi Jiangsu 214002 China Department of Hepatobiliary Surgery Wuxi Second People'sHospital Wuxi Jiangsu 214002 China Department of Intensive Care Unit First Affiliated Hospital SUNYat-sen University Guangzhou Guangdong 510000 China

Hemodynamic instability plays a major role in the pathogenesis of systemic inflammation, tissuehypoxia, and multiple-organ dysfunction syndrome associated with severe acute pancreatitis （SAP）. Aggressive fluid replacement is one of the key interventions for the hemodynamic support in severe acute pancreatitis.~Although the need for fluid resuscitation in severe pancreatitis is well established, the goals and components of this treatment are still a matter of debate. We used resuscitation strategies according to early goal- directed therapy （EGDT）; we measured the effects of these volume resuscitation on clinical outcomes such as organ function and mortality. Because frozen plasma is cheaper and more easily acquired than albumin for patients, we hypothesized that fluid resuscitation with frozen plasma according to EGDT would be associated with reduced incidence of organ failure and mortality as compared with individuals resuscitated with normal crystalloid and plasma substitute volume resuscitation.

关键词： therapy fresh frozen plasma resuscitation pancreatitis

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Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease

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World Journal of Hepatology 2022年第7期14卷 1421-1437页

作者： Sagnik Biswas Manas Vaishnav Piyush Pathak Deepak Gunjan Soumya Jagannath Mahapatra Saurabh Kedia Gyanranjan Rout Bhaskar Thakur Baibaswata Nayak Ramesh Kumar Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Division of Biostatistics UT Southwestern Medical CenterDallasTexas 75390United States Department of Gastroenterology All India Institute of Medical SciencesPatna 800014BiharIndia

BACKGROUND Platelet transfusion in acute variceal bleeding(AVB)is recommended by few guidelines and is common in routine clinical practice,even though the effect of thrombocytopenia and platelet transfusion on the outcomes of AVB is *** To determine how platelet counts,platelets transfusions,and fresh frozen plasma transfusions affect the outcomes of AVB in cirrhosis patients in terms of bleeding control,rebleeding,and *** Prospectively maintained database was used to analyze the outcomes of cirrhosis patients who presented with *** outcomes were assessed as the risk of rebleeding at days 5 and 42,and risk of death at day 42,considering the platelet counts and platelet *** score matching(PSM)was used to compare the outcomes in those who received platelet *** comparisons were done using Kaplan-Meier curves with log-rank tests and Coxproportional hazard model for rebleeding and for 42-d *** The study included 913 patients,with 83.5%men,median age 45 years,and Model for End-stage Liver Disease score *** count50×10^(9)/L were found in 23(2.5%),168(18.4%),and 722(79.1%)patients,*** rates were similar between the three platelet groups on days 5 and 42(13%,6.5%,and 4.7%,respectively,on days 5,P=0.150;and 21.7%,17.3%,and 14.4%,respectively,on days 42,P=0.433).At day 42,the mortality rates for the three platelet groups were also similar(13.0%,23.2%,and 17.2%,respectively,P=0.153).On PSM analysis patients receiving platelets transfusions(n=89)had significantly higher rebleeding rates on day 5(14.6%vs 4.5%;P=0.039)and day 42(32.6%vs 15.7%;P=0.014),compared to those who didn'*** mortality rates were also higher among patients receiving platelets(25.8%vs 23.6%;P=0.862),although the difference was not *** multivariate analysis,platelet transfusion and not platelet count,was independently associated with 42-d *** e

关键词： Gastrointestinal Hemorrhage Platelet transfusion Thrombocytopenia fresh frozen plasma Portal hypertension Mortality

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Acute Kidney Injury (AKI) in the Setting of Multi-Organ Dysfunction Syndrome (MODS) Secondary to Yellow Fever Infection (YFI) in a 19-Year-Old Woman

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Journal of Biosciences and Medicines 2020年第9期8卷 142-148页

作者： Peter K. Uduagbamen Charles J. Elikwu Adesola T. Oyelese Marion I. Ogunmola Tunde E. Thompson Tolulope E. Falana Division of Nephrology and Hypertension Department of Internal Medicine Babcock University Teaching Hospital Ilishan-Remo Nigeria Department of Medical Microbiology Babcock University Teaching Hospital Ilishan-Remo Nigeria Department of Hematology Babcock University Teaching Hospital Ilishan-Remo Nigeria

Background: Outbreak of yellow fever infection (YFI), a mosquito-borne disease, occurs sporadically worldwide especially in tropical nations. Acute kidney injury (AKI) commonly results from YFI and could be associated with a poor prognosis for victims even under intensive care unit (ICU). Pathophysiologic mechanisms for AKI include hypovolemic shut down, cytotoxicity, acute tubular necrosis (ATN), hemolysis, or coagulopathy. Early diagnosis, prompt and effective treatment modalities including dialysis improve treatment outcome. Aim: We report the case management of a 19-year-old woman who had yellow fever infection complicated by acute kidney injury in the setting of multi-organ dysfunction syndrome (MODS). Case Presentation: A 19-year-old woman who presented with fever, headache and vomiting for 2 weeks. In the course of the illness, urine volume became reduced and coke colored, followed by body swelling, yellowness of the eyes bleeding from the orifices. Examination revealed an acutely ill looking woman, icteric, and with pedal edema. Her pulse was 100/min and blood pressure was 120/80 mmHg. Liver was enlarged, soft and tender. She had proteinuria 3+ and polymerase chain reaction (PCR) confirmed yellow fever infection. She had markedly deranged serum biochemical parameters for which she had a three-hour session of hemodialysis with Heparin anticoagulation. The urea reduction ratio (URR) was 46.9%. Barrier nursing was commenced. She had 7 units of whole blood and a pint of fresh frozen plasma (FFP) with antibiotics, Rabeprazole, Tranexamic acid, Vitamin K and Frusemide. She had the second dialysis session of HD and entered into the recovering phase of AKI and was subsequently discharged after 18th days on admission. Conclusion: Yellow fever infection occurs sporadically and could lead to MODS involving the kidneys, liver and hematologic system. Prompt initiation of dialysis, correction of coagulopa

关键词： Acute Kidney Injury Acute Tubular Necrosis Dialysis Yellow Fever Virus fresh frozen plasma

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