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Association of anti-mullerian hormone and free androgen index level on response to clomiphene citrate in PCOS infertile women

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Gynecology and Obstetrics Clinical Medicine 2022年第4期2卷 203-207页

作者： Jasmine Kavitha Washington Jayasree Manivasakan Poomalar Gunasekaran Kala Sasikala R. Department of OBGyn Sree Balaji Medical College and HospitalChennaiIndia Department of OBGyn Sri Manakula Vinayagar Medical College and HospitalPondicherryIndia Department of OBGyn Aarupadai Veedu Medical College and HospitalPondicherryIndia

Background:Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** citrate,insulin-sensitizing drugs,aromatase inhibitors,gonadotropins,or laparoscopic ovarian drilling are various methods used for ovulation induction in women with *** women with high levels of anti-mullerian hormone(AMH)and free androgen index(FAI)do not respond well to ovulation *** prospective observational study explores the relationship between FAI and AMH levels on ovarian response to clomiphene citrate in infertile women with ***:This prospective observational study included 40 infertile with PCOS who underwent ovulation induction with clomiphene citrate with dose ranging from 50 to 150 *** were classified into four phenotypes by NIH(National Institute of Health)consensus panel *** clinical and endocrine parameters of participants who were sensitive to clomiphene were compared to those who were ***:The most common phenotype was A,with all three features of PCOS:hyperandrogenism,ovulatory dysfunction,and polycystic ovarian *** was no significant difference in clinical and endocrine parameters among the different phenotypes of PCOS except AMH and FAI *** mean FAI was 9.391.11 and AMH 7.260.48(ng/ml)in clomiphene resistant and 5.311.93 and 3.691.84(ng/ml)respectively in clomiphene-sensitive *** with FAI>7.5 and AMH>7 ng/ml might be resistant to ***:FAI and AMH values were significantly higher in women resistant to clomiphene *** and FAI may help women with PCOS to tailor their ovulation induction protocol.

关键词： free androgen index anti-Mullerian hormone Clomiphene Infertility Polycystic ovarian syndrome

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Increased free androgen index is associated with hypertension in premenopausal women

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Open Journal of Obstetrics and Gynecology 2011年第4期1卷 229-234页

作者： Liselott Andersson Mats Eliasson Inger Sundstrom Poromaa Department of Obstetrics and Gynecology Sunderby HospitalLuleaSweden Department of Internal Medicine Sunderby HospitalLuleaSweden Department of Public Health and Clinical Medicine Umea UniversityLuleaSweden Department of Women’s and Children’s Health Uppsala UniversityUppsalaSweden

Objective: Increased testosterone and decreased sex hormone-binding globulin (SHBG) are associated with a number of adverse cardiovascular risk factors in postmenopausal women. The aim of this population-based study of women aged 25 to 50 was to assess the relationship between free androgen index (FAI) and cardiovascular risk factors in premenopausal women. Methods: A population-based survey of 396 premenopausal women with no hormonal treatment was undertaken as part of the Northern MONICA study. The study involved questionnaires, anthropometry and assays of testosterone and SHBG. Results: Increased FAI was associated with a number of cardiovascular risk factors in premenopausal women but this relationship was strongly affected by body mass index (BMI). After adjustment for age and BMI, FAI was significantly associated with increased systolic and diastolic blood pressures. Conclusion: Hyperandrogenism is associated with increased blood pressure and these findings emphasize the need to assess cardiovascular risk factors in women with hyperandrogenism of all ages.

关键词： free androgen index Blood Pressure

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