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frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 450-477页

作者： Piao Zheng Zhen Huang Dong-Chang Tong Qing Zhou Sha Tian Bo-Wei Chen Di-Min Ning Yin-Mei Guo Wen-Hao Zhu Yan Long Wei Xiao Zhe Deng Yi-Chen Lei Xue-Fei Tian College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Integrated Traditional Chinese and Western Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Institute of Integrative Medicine Department of Integrated Traditional Chinese and Western MedicineXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang *** compounds show anticancer activity in other biological ***,whether frankincense and/or myrrh can inhibit the occurrence of hepatocellular carcinoma(HCC)is unknown,and the potential molecular mechanism(s)has not yet been *** To predict and determine latent anti-HCC therapeutic targets and molecular mechanisms of frankincense and myrrh in *** In the present study,which was based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(http://***/***),Universal Protein database(http://***),GeneCards:The Human Gene Database(http://***/)and Comparative Toxicogenomics Database(http://***/),the efficacy of and mechanism by which frankincense and myrrh act as anti-HCC compounds were *** core prediction targets were screened by molecular *** vivo,SMMC-7721 human liver cancer cells were transplanted as xenografts into nude mice to establish a subcutaneous tumor model,and two doses of frankincense plus myrrh or one dose of an EGFR inhibitor was administered to these mice continuously for 14 *** tumors were collected and evaluated:the tumor volume and growth rate were gauged to evaluate tumor growth;hematoxylineosin staining was performed to estimate histopathological changes;immunofluorescence(IF)was performed to detect the expression of CD31,α-SMA and collagen IV;transmission electron microscopy(TEM)was conducted to observe the morphological structure of vascular cells;enzyme-linked immunosorbent assay(ELISA)was performed to measure the levels of secreted HIF-1αand TNF-α;reverse transcription-polymerase chain reaction(RT-qPCR)was performed to measure the mRNA expression of HIF-1α,TNF-α,VEGF and MMP-9;and Western blot(WB)was performed to determine the levels of proteins expressed in the EGFR-mediated PI3K/Akt and

关键词： Hepatocellular carcinoma frankincense Myrrh Network pharmacology Tumor blood vessels Multiple signaling pathways

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Chemical Constituents and Pharmacological Properties of frankincense:Implications for Anticancer Therapy

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Chinese Journal of Integrative Medicine 2024年第8期30卷 759-767页

作者： WU Yong-rong XIONG Wei DONG Ying-jing CHEN Xin ZHONG Yuan-yuan HE Xin-ling WANG Yu-jia LIN Qun-fang TIAN Xue-fei ZHOU Qing College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha410208China Department of Andrology the First Hospital of Hunan University of Chinese MedicineChangsha41007China College of Medicine Hunan University of Chinese MedicineChangsha410208China College of Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Hunan Provincial Key Laboratory of Traditional Chinese Medicine Prescription and Transformation Changsha410208China Hunan Sexual and Reproductive Health Clinical Medical Research Center of Traditional Chinese Medicine Changsha410021China

The discovery of novel antitumor agents derived from natural plants is a principal objective of anticancer drug ***,a widely recognized natural antitumor medicine,has undergone a systematic review encompassing its species,chemical constituents,and diverse pharmacological activities and *** different species of frankincense include Boswellia serrata,Somali frankincense,Boswellia frereana,and Boswellia *** frankincense extracts and compounds exhibit antitumor,anti-inflammatory,and hepatoprotective properties and antioxidation,memory enhancement,and immunological regulation *** also have comprehensive effects on regulating *** and its principal chemical constituents have demonstrated promising chemoprophylactic and therapeutic abilities against *** review provides a systematic summary of the mechanism of action underlying the antitumor effects of frankincense and its major constituents,thus laying the foundations for developing effective tumor-combating targets.

关键词： frankincense species chemical constituents anticancer therapy Chinesemedicine

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Efficacy of frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome

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Chinese Journal of Integrative Medicine 2020年第7期26卷 519-526页

作者： Yung-Hsiang Chen Wen-Chi Chen Kao-Sung Tsai Po-Len Liu Ming-Yen Tsai Tzu-Chun Lin Shih-Chieh Yu Huey-Yi Chen Graduate Institute of Integrated Medicine College of MedicineResearch Center for Chinese Medicine and AcupunctureChinese Medicine Research CenterChina Medical UniversityTaichungTaiwanChina Departments of Medical Research Urologyand Obstetrics and GynecologyChina Medical University HospitalTaichungTaiwanChina Department of Psychology College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Department of Applied Cosmetology Master Program of Cosmetic ScienceHungkuang UniversityTaiwanChina Department of Respiratory Therapy College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Chinese Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwanChina Department of Dermatology Chung Shan University HospitalInstitute of MedicineSchool of MedicineChung Shan Medical UniversityTaichungTaiwanChina Department of Neurology Kuang Tien General HospitalTaichungTaiwanChina

Objective:To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome(IC/PBS).Methods:The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial cells(HUCs)were assessed in *** the animal study,48 virgin female rats were randomized into 4 groups(12 in each group):(1)control group(saline-injected control);(2)cyclophosphamide(CYP)group(intraperitoneal injected 150 mg/kg CYP);(3)CYP+pentosan polysulfate sodium group(orally received 50 mg/kg pentosan polysulfate sodium);and(4)CYP+frankincense and myrrha group[orally received frankincense(200 mg/kg)and myrrha(200 mg/kg)].Rats orally received pentosan polysulfate sodium or frankincense and myrrha on day 1,2,and *** experiments were performed on day *** and cystometry assessment behavior test were *** interval values were assessed in rats under ***,immunohistochemistry and Western blot were used to confirm the location and level,respectively,of cell junction-associated protein zonula occludens-2(ZO-2)***:Low dose frankincense and myrrha increased cell proliferation and migration in HUCs compared with control(Pfrankincense and myrrha group than CYP group(Pfrankincense+myrrha groups compared with the CYP-induced acute IC/PBS group(Pfrankincense and myrrha modulate urothelial wound healing,which ameliorates typical features of acute IC/PBS in rats.

关键词： frankincense myrrha acute interstitialcystitis painful bladder syndrome cell junction-associated protein

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frankincense,a Special Spice Walking Along the Silk Road

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Chinese Medicine and Culture 2018年第3期1卷 138-140页

作者： Tianwen Yao Baican Yang Department of Nephrology Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Department of Chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghaiChina

frankincense is also called“Fumigated land,”“Horsetail spice,”and“Godsend spice.”The alias“Fumigated land”shows its strong fragrance that can cover the whole *** name of“Horsetail spice”implies its morphologic characteristics and mild effects,and another name of“Godsend spice”indicates its functions of relieving swelling and pain,healing sore,and growing muscle,as if it is the grace donated by *** name of“frankincense”displays its complex productive *** thick quality and strong fragrance,frankincense acts as daily supplies for religious activities and folk activities due to its low price and a wide range of uses in medicine and daily *** shows the infinite charm of spice culture along the Silk Road from the distant Western Regions to the *** the same time,it enriches the treasure house of traditional Chinese medicine and becomes one of the most popular spices in both eastern and western,nobility and common.

关键词： frankincense fumigated land Godsend spice Horsetail spice spice culture in the western regions

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Geographical Origin and Level Identification of frankincense Based on Hyperspectral Image

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 469-480页

作者： Yu-Xiang Zhang Zhong-Chen Gao Ye-Xin Liu Wei Li School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

Background:As the demand for traditional Chinese medicinal materials increases in China and even the world,there is an urgent need for an effective and simple identification technology to identify the origin and quality of the latter and ensure the safety of clinical *** element analysis and isotope finger-printing are the two commonly used techniques in traditional origin *** of these techniques require the use of stoichiometric methods in the identification *** they have high accuracy and sensitivity,they are expensive and *** addition,near-infrared spectroscopy is a fast,nondestructive,and widely used identification technique developed in recent years,but its identification results are susceptible to samples’states and environmental conditions,and its sensitivity is *** imaging combines the advantages of imaging technology and optical technology,which can simultaneously access the image information and spectral information which reflect the external characteristics,internal physical structure,and chemical composition of the *** imaging is widely applied to agricultural product inspection,but research into its application in origin and quality identification of TCM materials is ***:In this study,the algorithm framework discriminative marginalized least squares regression(DMLSR)was used for feature extraction of frankincense hyperspectral *** DMLSR with intraclass compactness graph and manifold regularization can efficiently learn the projective samples with higher separability and less redundant information than the original ***,the discriminative collaborative representation with Tikhonov regularization(DCRT)was applied for classifying the geographical origin and level of *** introduces the discriminant regularization term and incorporates SID,which is more sensitive to the spectrum as the measurement method and is more suitable for the fran

关键词： Discriminative collaborative representation with Tikhonov regularization discriminative marginalized least squares regression frankincense geographical origin hyperspectral

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Effects of processing technology on essential oil and pharmacological action of frankincense

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Traditional Medicine Research 2021年第3期6卷 16-36页

作者： Xiang-Long Meng Yong-Lin Liang Chen-Zi Lyu Xiao-Juan Su Cong Hu Chen-Xu Ning Shuo-Sheng Zhang College of Chinese Materia Medica and Food Engineering Shanxi University of Chinese MedicineJinzhong 030619China School of Chinese Medicine Southern Medical UniversityGuangzhou 510515China School of Pharmacy Jiangxi Science and Technology Normal UniversityNanchang 330013China

Background:According to the traditional Chinese medicine theory,the common processing methods for Ruxiang(frankincense)include stir-frying processing and vinegar ***:With network pharmacology and thermal analysis methods,we selected and identified the main and irritating ingredients,established the pyrolysis characteristic parameters for identifying frankincense quality,quantified the starting and optimum temperature limits for processing frankincense,and analyzed the influences of processing adjuvants(vinegar)on combustion pyrolysis characteristics of *** applying Fourier transformation infrared spectrometry,high performance liquid chromatography,gas chromatography and UV-visible spectrometry,we evaluated the processing technology developed in our study of frankincense and its processed ***:Based on network pharmacology,we can find that the classical compounds of essential oil are the main pharmacodynamics components of frankincense possessing the anti-inflammatory,analgesia,anti-tumor,anti-ulcer and ant-inflammatory bowel disease *** pyrolysis combustion rate peaks of frankincense at 285.27±7.05℃and 476.99±13.46℃were the characteristic peaks used to identify frankincense *** specific temperature of slow-fire processing,including the vinegar processing and stir-frying processing,was 148.72±5.09℃.Heating for 5.67±0.98 min after reaching processing temperature was needed for processing frankincense with *** kinetics analysis showed that both frankincense and its vinegar mixture exhibited good linear *** feasibility and practicability for our processing technology were verified through the determination of medicinal compounds by Fourier transformation infrared spectrometry,high performance liquid chromatography,gas chromatography and ***:frankincense essential oils were the main active components of frankincense,which also can be taken as the internal chemical control indexes to ju

关键词： frankincense Processing methods Vinegar processing Essential oil Inflammatory Thermal gravimetric analysis

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Investigating the effect of extraction procedure on the anti-inflammatory metabolites of olibanum resin from different Boswellia species through LC-MS/MS-based metabolomics

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Food Bioscience 2023年第3期53卷 1665-1677页

作者： Hanaa M.M.Elhaddad Hala M.Hammoda Doaa A.Ghareeb Fatma A.A.Mahmoud Ahmed Hussein Mokhtar Ibrahim Yousef Reham S.Darwish Eman Shawky Department of Pharmacognosy Faculty of PharmacyAlexandria UniversityEgypt Bio-screening and Preclinical Trial Lab Biochemistry DepartmentFaculty of ScienceAlexandria UniversityAlexandriaEgypt Biochemistry Department Faculty of ScienceAlexandria UniversityAlexandriaEgypt Department of Biotechnology Institute of Graduate Studies and ResearchAlexandriaEgypt Department of Environmental Studies Institute of Graduate Studies and ResearchAlexandriaEgypt

Olibanum is a resinous extract extracted from several species of Boswellia *** works aims to contribute to the research on the chemistry and anti-inflammatory activity of raw,acidic and neutral fractions of different olibanum species to determine the effects of different extraction procedures on the composition of anti-inflammatory *** profiling of different fractions of Boswellia species was attempted using UPLC/MS/MS coupled to chemometric *** anti-inflammatory activity of the tested extracts was assessed on LPS-stimulated WBCs through four pro-inflammatory cytokines(TNF-α,IL-6,IL-1βand IFN-γ)in addition to reveal the efficacy-directed markers using multivariate ***/MS/MS analysis led to the annotation of 77 compounds belonging to several chemical *** models indicated that samples segregation was based on the geographical source of the oleo-gum-resin rather than extraction *** and neutral extracts of *** and *** alcoholic extract were strongly correlated to inhibition of the pro-inflammatory markers IL-1βand TNF-αwhile there was a strong correlation between the raw extract of *** and the alcoholic extract of *** activity to IFN-γ***,the most active extracts against IL-6 were the acidic and raw extracts of *** and ***.

关键词： frankincense Extraction Anti-inflammatory Metabolomics UPLC/MS/MS

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Distribution Boswellia sacra in Dhofar Mountains, Sultanate of Oman： Economic Value and Environmental Role

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Journal of Life Sciences 2012年第6期6卷 632-636页

作者： Mohsin Musalim Hassan Alaamri Salalah Agriculture Research Station Ministry of Agriculture & Fisheries Salalah 112 Sultanate of Oman

Boswellia sacra from Burseraceae family, grows is limited and the land unsuitable for traditional agriculture wild in dry hot lands of southern part of Oman （Dhofar）, where the water purpose. Boswellia sacra is a multipurpose tree, but more famous for its high value olibanum. The olibanum is used for ritual and in church ceremonies worldwide, traditional medicines, pharmaceutical, perfumery, cosmetics, chewing, painting, food flavouring. In addition to this, the species has other numerous environmental, historical, and socio-economical benefits. This study is based on literature reviews, and on the interview local people, as well as on personal field experiences. The objective is to introduce the importance of the species and to study the native habitats, the distribution, and the harvesting techniques. The soil is carbonitic, isohypertherrnic, lithic torriothent, poor in mineral elements. The olibanum produces when the tree tapped by making a thin vertical slicing into the tree trunk. Initial size should be about 18 cm2 （3 × 6 cm） and 1-2 mm in depth and the diameter tree trunk should be not less than 10 cm. Tree tapping should be stopped 2-3 weeks before the rain season. The method of tree tapping and olibanum collection need to be revised for long-term tree protection.

关键词： Olibanum frankincense tree tapping soil carbonitic isohyperthermic lithic torriothent

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