检索结果-南通市图书馆

Overcoming adaptive resistance in AML by synergistically targeting foxo3a-GNG7-mTOR axis with foxo3a inhibitor Gardenoside and rapamycin

引用

Genes & Diseases 2024年第1期11卷 397-412页

作者： Zhe Chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting foxo3a(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target foxo3a are lacking and the adaptive response signaling weakens the cytotoxic effect of foxo3a depletion on AML cells.Here,we show that foxo3a deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive resistance.Mitochondrial metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,foxo3a directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of mTOR.Consequently,combinatorial inhibition of foxo3a and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of AML.Through a structure-based virtual screening,we report one potent small-molecule foxo3a inhibitor(Gardenoside)that exhibits a strong effect of anti-foxo3a DNA binding.Gardenoside synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft model.These results demonstrate that mTOR can mediate adaptive resistance to foxo3a inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition foxo3a GNG7 mTOR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

foxo3a对线粒体功能的调控作用及机制

引用

中国药理学通报 2024年第5期40卷 806-810页

作者：李杰张丽汪晓寒郭家彬中国人民解放军疾病预防控制中心北京100071 中国医科大学公共卫生学院辽宁沈阳110001

叉头框蛋白O3a(fork head box O3a,foxo3a)是叉头框蛋白FOX转录因子O亚型家族中成员,作为一种转录调节因子在多种疾病的发生与发展中发挥重要调节作用。线粒体是细胞能量代谢的主要场所,也是维持细胞生长和功能的一类关键细胞器。线粒... 详细信息

叉头框蛋白O3a(fork head box O3a,foxo3a)是叉头框蛋白FOX转录因子O亚型家族中成员,作为一种转录调节因子在多种疾病的发生与发展中发挥重要调节作用。线粒体是细胞能量代谢的主要场所,也是维持细胞生长和功能的一类关键细胞器。线粒体功能受到多种转录因子调控。foxo3a可定位于线粒体,通过调节细胞核与线粒体之间的相互作用,对线粒体功能产生重要影响,其机制与调节线粒体能量代谢、生物合成、自噬、分裂/融合,以及线粒体钙稳态密切相关。该文重点综述了foxo3a的生物学功能、及其对线粒体的调控作用与机制。

关键词： foxo3a 线粒体氧化应激转录因子功能紊乱调控机制

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

槲皮素通过调控foxo3a/TXNIP通路对神经细胞焦亡的影响

引用

中药材 2024年 1271-1276页

作者：左洁仪徐汪洋陈洪栋郑晓宇罗思东王业杨广东省第二人民医院

目的:探究槲皮素通过调控foxo3a/TXNIP通路对H2O2诱导下神经细胞焦亡的影响。方法:100μmol/L H2O2处理神经细胞株PC-12建立神经细胞损伤模型,随后采用不同浓度的槲皮素处理。细胞分组如下:空白对照组（正常培养的PC-12细胞）、模型组（... 详细信息

目的:探究槲皮素通过调控foxo3a/TXNIP通路对H2O2诱导下神经细胞焦亡的影响。方法:100μmol/L H2O2处理神经细胞株PC-12建立神经细胞损伤模型,随后采用不同浓度的槲皮素处理。细胞分组如下:空白对照组（正常培养的PC-12细胞）、模型组（H2O2处理PC-12细胞）、槲皮素组（6.2、12.5、25μmol/L槲皮素处理24 h后,再用H2O2处理PC-12细胞）、si-NC+槲皮素组（non-specific si RNA转染细胞后,H2O2和12.5μmol/L槲皮素处理细胞）、si-foxo3a+槲皮素组（foxo3a si RNA转染细胞后,H2O2和12.5μmol/L槲皮素孵育细胞）、si-foxo3a si+si-NC+槲皮素组（同时转染foxo3a si RNA和non-specific si RNA后,12.5μmol/L槲皮素和H2O2处理细胞）、sifoxo3a+si-TXNIP+槲皮素组（同时转染foxo3a si RNA和TXNIP si RNA后,12.5μmol/L槲皮素和H2O2处理细胞）。在H2O2处理的PC-12细胞中加入蛋白合成酶抑制剂环己酰亚胺,检测foxo3a降解情况。CCK-8法检测细胞活力;Caspase-1 FLICA/PI双染法检测细胞焦亡;RT-qPCR检测foxo3a、TXNIP m RNA表达;Western Blot检测Caspase-1、foxo3a、TXNIP蛋白表达;ELISA法检测细胞培养上清中IL-1β、IL-18含量。结果:与模型组比较,槲皮素12.5、25μmol/L组细胞活力、foxo3a m RNA及蛋白表达显著升高,焦亡率及IL-1β、IL-18分泌量和TXNIP m RNA表达及Caspase-1、foxo3a、TXNIP蛋白表达显著降低。抑制foxo3a表达可逆转槲皮素的作用,抑制TXNIP表达可逆转抑制foxo3a表达对槲皮素作用的影响。结论:槲皮素可通过抑制foxo3a降解,下调TXNIP的表达水平,进而抑制PC-12细胞焦亡。

关键词：槲皮素焦亡 foxo3a TXNIP 脊髓损伤

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

川陈皮素通过foxo3a/SIRT1通路减轻脂多糖诱导的肺损伤

引用

医学研究杂志 2024年第4期53卷 75-79,9页

作者：杨青万俊华范国华武汉大学人民医院儿科 430061 武汉大学人民医院胸外科 430061

目的观察川陈皮素在脓毒症肺损伤中的作用,并探究其潜在机制。方法采用随机数字表法将48只8~10周的雄性C57 BL/6小鼠分为4组,即对照组、肺损伤组、治疗组(5mg/kg)和治疗组(10mg/kg),每组各12只。对照组不做任何处理;肺损伤组小鼠腹腔... 详细信息

目的观察川陈皮素在脓毒症肺损伤中的作用,并探究其潜在机制。方法采用随机数字表法将48只8~10周的雄性C57 BL/6小鼠分为4组,即对照组、肺损伤组、治疗组(5mg/kg)和治疗组(10mg/kg),每组各12只。对照组不做任何处理;肺损伤组小鼠腹腔注射脂多糖(10mg/kg);治疗组(5mg/kg)小鼠接受腹腔注射脂多糖(10mg/kg)的同时予以川陈皮素(5mg/kg)灌胃;治疗组(10mg/kg)小鼠接受腹腔注射脂多糖(10mg/kg),同时予以川陈皮素(10mg/kg)灌胃。脂多糖腹腔注射12h后,检测各组小鼠肺功能及动脉血气,同时留取肺组织,分别从病理学和分子生物学层面评估小鼠肺损伤状况及可能靶点。结果与对照组比较,肺损伤组小鼠气道压力、PaCO_(2)、肺损伤评分明显增高,PaO_(2)明显降低(Pfoxo3a和SIRT1的蛋白表达水平较对照组明显降低(Pfoxo3a和SIRT1蛋白表达水平明显上调(Pfoxo3a/SIRT1通路激活有关。

关键词：川陈皮素急性肺损伤脓毒血症 SIRT1 foxo3a

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

溶质载体家族2成员12干预尿酸诱导肾小管细胞的损伤

引用

中国组织工程研究 2024年第13期28卷 2076-2081页

作者：贺怡李晓林何金科蒋香菊梁美婷陈邬锦崔月娜孙玉萍新疆第二医学院新疆维吾尔自治区克拉玛依市834000 新疆医科大学基础医学院新疆维吾尔自治区乌鲁木齐市830000

背景:近年来,由嘌呤代谢紊乱引起的高尿酸血症的发病率不断增加,可诱导炎症反应并导致肾损伤。目的:探讨溶质载体家族2成员12(solute carrier family 2 member 12,SLC2A12)在高尿酸相关肾损伤中的作用和机制。方法:将肾小管细胞(HK2细胞... 详细信息

背景:近年来,由嘌呤代谢紊乱引起的高尿酸血症的发病率不断增加,可诱导炎症反应并导致肾损伤。目的:探讨溶质载体家族2成员12(solute carrier family 2 member 12,SLC2A12)在高尿酸相关肾损伤中的作用和机制。方法:将肾小管细胞(HK2细胞)分为5组:HK2组、HK2+尿酸组、HK2+尿酸+NC组、HK2+尿酸+siSLC2A12组、HK2+尿酸+siSLC2A12+MK-2206组。用尿酸处理HK2细胞后转染siRNA SLC2A12,再通过MK-2206处理抑制AKT表达。采用CCK-8检测细胞增殖能力,TUNEL检测细胞凋亡情况,qRT-PCR和Western blot检测纤维化因子以及AKT/foxo3a途径相关因子的表达,酶联免疫吸附实验检测细胞上清液中炎性细胞因子水平。结果与结论:①与HK2组比较,HK2+尿酸组细胞增殖能力降低,细胞凋亡增多,HK2+尿酸+siSLC2A12组细胞增殖能力进一步降低,凋亡细胞进一步增多;与HK2+尿酸+siSLC2A12组比较,HK2+尿酸+siSLC2A12+MK-2206组细胞增殖能力升高,凋亡细胞减少;②与HK2组比较,HK2+尿酸组细胞中结缔组织生长因子、α-平滑肌肌动蛋白、转化生长因子β表达升高,HK2+尿酸+siSLC2A12组3种因子表达进一步升高;与HK2+尿酸+siSLC2A12组比较,HK2+尿酸+siSLC2A12+MK-2206组3种因子表达有所下降;③与HK2组比较,HK2+尿酸组p-AKT、foxo3a、p-foxo3a表达升高,HK2+尿酸+siSLC2A12组p-AKT表达进一步升高,而foxo3a、p-foxo3a表达下降;与HK2+尿酸+siSLC2A12组比较,HK2+尿酸+siSLC2A12+MK-2206组p-AKT表达下降,foxo3a、p-foxo3a表达升高;④与HK2组比较,HK2+尿酸组白细胞介素6、白细胞介素1β、肿瘤坏死因子α分泌水平升高,HK2+尿酸+siSLC2A12组白细胞介素6、白细胞介素1β、肿瘤坏死因子α水平进一步升高;与HK2+尿酸+siSLC2A12组比较,HK2+尿酸+siSLC2A12+MK-2206组白细胞介素6、白细胞介素1β、肿瘤坏死因子α水平下降;⑤结果表明,SLC2A12可能通过激活foxo3a途径抵抗尿酸诱导的肾小管纤维化及炎症反应,从而保护高尿酸血症诱导的肾脏损伤。

关键词：高尿酸血症 SLC2A12 AKT foxo3a 信号通路纤维化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibition of foxo3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury

引用

Acta Pharmaceutica Sinica B 2019年第3期9卷 505-515页

作者： Junke Song Wen Zhang Jinhua Wang Haiguang Yang Qimeng Zhou Haigang Wang Li Li Guanhua Du State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of MedicalSciences and Peking Union Medical CollegeBeijing100050China

Salvianolic acid A(SalA) is an effective compound extracted from traditional Chinese medicine Salvia miltiorrhiza Bunge. The Forkhead box O3a(foxo3a) signaling pathway plays crucial roles in the modulation of ischemia-induced cell apoptosis. However, no information about the regulatory effect of SalA on foxo3a is available. To explore the anti-cerebral ischemia effect and clarify the therapeutic mechanism of SalA, SH-SY5Y cells and Sprague–Dawley rats were applied, which were exposed to oxygen glucose deprivation/reoxygenation(OGD/R) and middle cerebral artery occlusion/reperfusion(MCAO/R) injuries, respectively. The involved pathway was identified using the specific inhibitor LY294002. Results showed that SalA concentration-dependently inhibited OGD/R injury triggered cell viability loss. SalA reduced cerebral infarction, lowered brain edema, improved neurological function, and inhibited neuron apoptosis in MCAO/R rats, which were attenuated by the treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K) specific inhibitor LY294002. SalA time-and concentration-dependently upregulated the phosphorylation levels of protein kinase B(AKT) and its downstream protein foxo3a. Moreover, the nuclear translocation of foxo3a was inhibited by SalA both in vivo and in vitro, which was also reversed by LY294002. The above results indicated that SalA fought against ischemia/reperfusion damage at least partially via the AKT/foxo3a/BIM pathway.

关键词： Salvianolic acid A Ischemia reperfusion foxo3a BIM Neuroprotection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between foxo3a gene polymorphisms and human longevity： a meta-analysis

引用

Asian Journal of Andrology 2014年第3期16卷 446-452页

作者： Ji-Ming Bao Xian-Lu Song Ying-Qia Hong Hai-Li Zhu Cui Li Tao Zhang Wei Chen Shan-Chao Zhao Qing Chen Department of Urology and Medical Center for Overseas Patients Nanfang HospitaIGuangzhou Department of Radiotherapy Cancer Center of Guangzhou Medical University Guangzhou Department of Pediatric Surgery The First Affiliated Hospital of Shantou University Medical College Shantou School of Basic Medical Sciences Southern Medical University Guangzhou Department of Epidemiology School of Public Health and Tropical Medicine Southern Medical University Guangzhou China.

Numerous studies have shown associations between the foxo3a gene, encoding the forkhead box 03 transcription factor, and human or specifically male longevity. However, the associations of specific foxo3a polymorphisms with longevity remain inconclusive. We performed a meta-analysis of existing studies to clarify these potential associations. A comprehensive search was conducted to identify studies of foxo3a gene polymorphisms and longevity. Pooled odds ratios （ORs） and 95% confidence intervals （Cls） were calculated by comparing the minor and major alleles. A total of seven articles reporting associations of foxo3a polymorphisms with longevity were identified and included in this meta-analysis. These comprised 11 independent studies with 5241 cases and 5724 controls from different ethnic groups, rs2802292, rs2764264, rs13217795, rs1935949 and rs2802288 polymorphisms were associated with human longevity （OR = 1.36, 95% Cl = 1.10-1.69, P= 0.005; OR = 1.20, 95% CI = 1.04-1.37, P= 0.01; OR = 1.27, 95% CI = 1.10-1.46, P= 0.001; OR = 1.14, 95% CI = 1.01-1.27 and OR = 1.24, 95% CI = 1.07-1.43, P= 0.003, respectively）. Analysis stratified by gender indicated significant associations between rs2802292, rs2764264 and rs13217795 and male longevity （OR = 1.54, 95% Cl = 1.33-1.79, P〈 0.001; OR = 1.38, 95% Cl = 1,15-1.66, P= 0.001; and OR = 1.39, 95% Cl = 1.15-1.67, P= 0.001）, but rs2802292, rs2764264 and rs1935949 were not linked to female longevity. Moreover, our study showed no association between rs2153960, rs7762395 or rs13220810 polymorphisms and longevity. In conclusion, this meta-analysis indicates a significant association of five foxo3a gene polymorphisms with longevity, with the effects of rs2802292 and rs2764264 being male-specific, Further investigations are required to confirm these findings.

关键词： foxo3a longevity meta-analysis polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remarkably Reduced Expression of foxo3a in Metaplastic Colorectum, Primary Colorectal Cancer and Liver Metastasis

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第2期33卷 205-211页

作者：何乐亚魏欣杜蕾刘鹭徐丰闵江李川陶德定陈佺胡俊波龚建平 Department of Gastrointestinal Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology The Laboratory of Apoptosis and Cancer Biology the State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences

The forkhead family members of transcription factors （foxos） are expected to be potential cancer-related drug targets and thus are being extremely studied recently. In the present study, foxo3a, one major member of this family, was identified to be down-regulated in colorectal cancer through mi- cro-array analysis, which was confirmed by RT-PCR and Western blot in 28 patients. Moreover, immu- nohistochemistry （IHC） showed that the expression levels of foxo3a were remarkably reduced in 99 cases of primary colorectal cancer, liver metastasis, and even in metaplastic colorectal tissue. IHC also revealed an exclusion of foxo3a from the nucleus of most cells of tumor-associated tissues. Silencing foxo3a by siRNA led to elevation of G2-M phase cells. We conclude that the downregulation of foxo3a may greatly contribute to tumor development, and thus foxo3a may represent a novel thera- peutic target in colorectal cancer.

关键词： foxo3a colorectal cancer transcription factor cell cycle arrest target therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

三氧化二砷通过foxo3a/cofilin-1通路调控肺腺癌A549细胞的增殖、凋亡、迁移和侵袭能力

引用

肿瘤 2022年第2期42卷 144-155页

作者：韩燕燕郑旭李翀吕艳天津中医药大学第一附属医院病理科天津300000 国家中医针灸临床医学研究中心天津300000

目的:研究三氧化二砷(arsenic trioxide,ATO)对肺腺癌A549细胞的增殖、凋亡、迁移和侵袭能力的影响,及可能的作用机制。方法:用不同浓度的ATO处理肺腺癌A549细胞后,采用CCK-8法检测ATO对A549细胞增殖的影响,以及蛋白质印迹法检测ATO对A... 详细信息

目的:研究三氧化二砷(arsenic trioxide,ATO)对肺腺癌A549细胞的增殖、凋亡、迁移和侵袭能力的影响,及可能的作用机制。方法:用不同浓度的ATO处理肺腺癌A549细胞后,采用CCK-8法检测ATO对A549细胞增殖的影响,以及蛋白质印迹法检测ATO对A549细胞核和细胞质中foxo3a蛋白表达水平的影响。采用si RNA干扰的方法下调A549细胞中foxo3a m RNA和蛋白的表达水平,随后分别采用流式细胞术(flow cytometry,FCM)、细胞划痕愈合实验及Transwell小室实验检测ATO单药处理、沉默foxo3a表达、沉默foxo3a表达联合ATO处理以及LY294002单药处理对A549细胞凋亡、迁移及侵袭能力的影响,最后再用蛋白质印迹法检测对A549细胞中丝切蛋白1(cofilin-1)及磷酸化cofilin-1(phosphorylated cofilin-1,p-cofilin-1)蛋白表达水平的影响。结果:ATO能抑制A549细胞的增殖(Pfoxo3a蛋白的表达水平显著升高(Pfoxo3a蛋白的表达水平显著降低(Pfoxo3a表达后,A549细胞的凋亡率显著降低(Pfoxo3a表达导致的A549细胞的凋亡率的降低(Pfoxo3a表达后细胞中p-cofilin-1蛋白的表达水平显著上调(Pfoxo3a表达导致的p-Cofilin-1蛋白表达水平的上调(Pfoxo3a可能为ATO抑制肺癌恶性进展的一个潜在靶点,且foxo3a可能通过激活cofilin-1的磷酸化发挥抑癌作用。

关键词：非小细胞肺癌三氧化二砷 foxo3a Cofilin-1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

miRNA-155 Modulates the Malignant Biological Characteristics of NK/T-Cell Lymphoma Cells by Targeting foxo3a Gene

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第6期34卷 882-888页

作者：姬卫国张旭东孙向东王祥麒常保萍张明智 Department of Oncology The First Affiliated Hospital of Zhengzhou University Department of Science and Research Henan University of Traditional Chinese Medicine Department of Oncology Henan University of Traditional Chinese Medicine Department of Hematology The Second Affiliated Hospital of Henan University of Science and Technology

This study investigated the effects of miRNA-155 on malignant biological characteristics of NK/T-cell lymphoma cell lines and the possible mechanism. The expression of miRNA-155 was detected in lymphoma cell lines from different sources （SNK-6, YTS, Jurkat and DOHH2） by real-time PCR. Lentiviral vectors （pLL3.7） that could overexpress or downexpress miRNA-155 were constructed. Recombinant lentiviral particles were prepared and purified, and their titers determined. The expression of miRNA-155 in the infected SNK-6 cells and the cell proliferation were detected by PCR and CCK-8, respectively. Flow cytometry was used to determine the apoptosis of infected SNK-6 cells. The target of miRNA155 was predicted from Targetscan website. The effect of miRNA155 on foxo3a expression was examined by Western blotting. The results showed that among the human NK/T-cell lymphoma cell lines SNK-6, YTS, Jurkat and DOHH2, the expression of miRNA-155 was highest in SNK-6. The infection efficiency of the recombinant lentivirns in SNK-6 was more than 70% at multiplicity of infection （MOI） of 100. The expression of miRNA-155 was significantly increased in SNK-6 cells infected by lentivirus vectors with high expression of miRNA-155 （4 times higher than the control group）, and profoundly decreased in those infected with lentivirnses with low expression of miRNA-155. The proliferation of letivirns-infected SNK-6 cells was decreased as the expression of miRNA-155 reduced. The apoptosis rate was increased with the reduction in the expression of miRNA-155. foxo3a was found to be a possible target of miRNA155, as suggested by Targetscan website. Western blotting showed that the expression of foxo3a was significantly elevated in SNK-6 cells with miRNA-155 inhibition. It was concluded that reduction in miRNA-155 expression can inhibit the proliferation of SNK-6 lymphoma cells and promote their apoptosis, which may be associated with regulation of foxo3a gene.

关键词： miRNA-155 lentiviral vector NK/T-cell lymphoma cell lines apoptosis foxo3a

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：