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Integrative Modeling of Oxidative Stress and C1 Metabolism Reveals Upregulation of formaldehyde and Downregulation of Glutathione

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ye-Nan CHI~a,Guo-Gang XING~(a,b,*),Xu ZHANG~c,Jie CAI~a,Feng-Yu LIU~a,You WAN~(a,b,*) a Neuroscience Research Institute and Department of Neurobiology,Peking University,38 Xue-Yuan Road,Beijing 100191,China bKey Laboratory for Neuroscience of the Ministry of Education and the Ministry of Public Health,38 Xue-Yuan Road, Beijing 100191,China c Central Laboratory,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Xuanwu Hospital, Capital Medical University

It has been demonstrated that cancer tissues can secret endogenous *** the central nervous system,formaldehyde at pathological concentration can induce misfolding and aggregation of neuronal tau in hippocampus neurons,which is closely related to *** present study aims to find the involved ion channels of formaldehyde effect on hippocampus *** calcium is an important intracellular messenger,playing a key role in the whole cell *** on the changes of intracellular calcium signaling([Ca])by confocal images,we found that formaldehyde at a low concentration(1 mM)could increase[Ca] in primary cultured hippocampal neurons by one ***(2R)-amino-5-phosphonopentanoate(AP5,25μM,a selective NMDAR antagonist)and mibefradil(1μM,a blocker of T-type calcium channels),given five minutes after formaldehyde perfusion,partially reverses the increased[Ca] of hippocampus neurons,and this effect could be reinforced when they are given *** minutes before formaldehyde perfusion,AP5(even at 50μM)could not inhibit the formaldehyde-induced[Ca] *** mibefradil(1μM),given three minutes before formaldehyde,can significantly inhibit formaldehyde effect nearly by *** results suggest that formaldehyde at a very low pathological concentration could increase intracellular calcium concentration in hippocampal neurons;NMDA receptors and T-type calcium channels are the main potential targets of formaldehyde.

关键词： formaldehyde intracellular calcium hippocampal neurons T-type calcium channels NMDA receptors

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American Journal of Plant Sciences 2015年第9期6卷 1527-1542页

作者： Mrudhuula Mohan Santhiya Kothandaram Vyshali Venugopal Prabhakar Deonikar V. A. Shiva Ayyadurai Systems Biology Group International Center for Integrative Systems Cambridge MA USA

This research provides, to the authors’ knowledge, the first integrative model of oxidative stress and C1 metabolism in plants. Increased oxidative stress can cause irreversible damage to photosynthetic components and is harmful to plants. Perturbations at the genetic level may increase oxidative stress and upregulate antioxidant systems in plants. One of the key mechanisms involved in oxidative stress regulation is the ascorbate-glutathione cycle which operates in chloroplasts as well as the mitochondria and is responsible for removal of reactive oxygen species (ROS) generated during photosynthetic operations and respiration. In this research, the complexity of molecular pathway systems of oxidative stress is modeled and then integrated with a previously developed in silico model of C1 metabolism system. This molecular systems integration provides two important results: 1) demonstration of the scalability of the CytoSolve®?Collaboratory™, a computational systems biology platform that allows for modular integration of molecular pathway models, by coupling the in silico model of oxidative stress with the in silico model of C1 metabolism, and 2) derivation of new insights on the effects of oxidative stress on C1 metabolism relative to formaldehyde (HCHO), a toxic molecule, and glutathione (GSH), an important indicator of oxidative homeostasis in living systems. Previous in silico modeling of C1 metabolism, without oxidative stress, observed complete removal of formaldehyde via formaldehyde detoxification pathway and no change in glutathione concentrations. The results from this research of integrative oxidative stress with C1 metabolism, however, demonstrate significant upregulation of formaldehyde concentrations, with concomitant downregulation and depletion of glutathione. Sensitivity analysis indicates that kGSH-HCHO, the rate constant of GSH-HCHO binding, VSHMT, the rate of formation of sarcosine from glycine, and , the rate of superoxide formation signifi

关键词： C1 Metabolism Oxidative Stress formaldehyde Glutathione formaldehyde Detoxification Methionine Biosynthesis Methylation Cycle Computational Systems Biology CytoSolve Systems Integration Molecular Pathways

Case Report: Autoimmune Disease Triggered by Exposure to Hair Straightening Treatment Containing formaldehyde

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第1期3卷 1-6页

作者： James Dahlgren Rhett Roback Maria Dominguez Vera Byers David Silver Edward Faeder Immunology Inc. Incline Village USA James Dahlgren Medical Santa Monica USA Srf Environmental & Health Management Inc. Diamond Bar USA UCLA David Geffen School of Medicine Los Angeles USA

formaldehyde (FHO) is a multipurpose chemical that is an eye, nose, throat and skin irritant, sensitizer and allergen, as well as a class 1 human carcinogen. Brazilian hair treatments, containing high levels of FHO (up to 11%), have become regularly used that have the potential to expose clients to toxic levels in excess of current regulatory standards. We report on a patient who underwent a single hair treatment and subsequently developed an autoimmune disease. We review the relevant literature on autoimmune disease and formaldehyde exposure. Our case adds to existing knowledge and suggests that physicians ask their patients about commercial products that contain formaldehyde when diagnosing autoimmune conditions.

关键词： formaldehyde Autoimmune Chemical Exposure Brazilian Blowout Hair Treatment

Factor Affecting Gel Time/Process-Ability of Urea formaldehyde Resin Based Wood Adhesives

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Open Journal of Polymer Chemistry 2017年第2期7卷 33-42页

作者： Ravindra V. Gadhave Prakash A. Mahanwar Pradeep T. Gadekar Department of Polymer and Surface Engineering Institute of Chemical Technology (ICT) Mumbai India

Urea-formaldehyde (UF) resin presents the most utilized adhesive system in the manufacture of plywood, particleboard and fiberboard. At the temperatures above 100°C in the presence of hardener, this resin undergoes cross-linking reaction and the formation of three dimensional cross linked structures takes place and bonding of wood particles in a hot press [1]. UF powder resins show high reactivity and good performance in the production and by their low price;however they lack in water resistance of the hardened resin [2]. Urea-formaldehyde (UF) resins are the most important type of adhesive resins for the production of wood based panels but process-ability and curing behavior of urea formaldehyde resin depended on various factors related to resin properties, types of wood and their properties, amount & type of catalyst, types and amount of polymers addition and environmental conditions [3]. This factor decides the process-ability of UF resin based composite during manufacturing of plywood, particle board and fiberboard. In this review paper, various factors affecting gel time and process-ability of UF resin based wood composite are reviewed.

关键词： Urea formaldehyde Resins Catalysts Gel Time Wood pH Polyvinyl Acetate Composite

Do GMOs Accumulate formaldehyde and Disrupt Molecular Systems Equilibria? Systems Biology May Provide Answers

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Agricultural Sciences 2015年第7期6卷 630-662页

作者： V. A. Shiva Ayyadurai Prabhakar Deonikar Systems Biology Group International Center for Integrative Systems Cambridge MA USA

Safety assessment of genetically modified organisms (GMOs) is a contentious topic. Proponents of GMOs assert that GMOs are safe since the FDA’s policy of substantial equivalence considers GMOs “equivalent” to their non-GMO counterparts, and argue that genetic modification (GM) is simply an extension of a “natural” process of plant breeding, a form of “genetic modification”, though done over longer time scales. Anti-GMO activists counter that GMOs are unsafe since substantial equivalence is unscientific and outdated since it originates in the 1970s to assess safety of medical devices, which are not comparable to the complexity of biological systems, and contend that targeted GM is not plant breeding. The heart of the debate appears to be on the methodology used to determine criteria for substantial equivalence. Systems biology, which aims to understand complexity of the whole organism, as a system, rather than just studying its parts in a reductionist manner, may provide a framework to determine appropriate criteria, as it recognizes that GM, small or large, may affect emergent properties of the whole system. Herein, a promising computational systems biology method couples known perturbations on five biomolecules caused by the CP4 EPSPS GM of Glycine max L. (soybean), with an integrative model of C1 metabolism and oxidative stress (two molecular systems critical to plant function). The results predict significant accumulation of formaldehyde and concomitant depletion of glutathione in the GMO, suggesting how a “small” and single GM creates “large” and systemic perturbations to molecular systems equilibria. Regulatory agencies, currently reviewing rules for GMO safety, may wish to adopt a systems biology approach using a combination of in silico, computational methods used herein, and subsequent targeted experimental in vitro and in vivo designs, to develop a systems understanding of “equivalence” using biomarkers, such as formaldehyde and glutathione, which predict m

关键词： Substantial Equivalence Genetic Modification GMOs formaldehyde Glutathione CytoSolve Systematic Review Systems Biology Bioinformatics Molecular Pathways C1 Metabolism Oxidative Stress Maize Methionine Biosynthesis Methylation Cycle formaldehyde Detoxification

Effects of formaldehyde and Low-light Stress on Growth and Nutrition of Hedera spp.

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Agricultural Biotechnology 2018年第5期7卷 48-53,57页

作者： Yongfu ZHANG Shengjing PENG Yanfen NIU College of Agriculture Kunming University

Potted seedlings of Hedera nepalensis and H. helix were exposed to formaldehyde and low light alone or in combination for four months, before the morphological and nutritive indices of the plants were measured to assess the effects of formaldehyde and low-light stress on the growth and nutrient accumulation of Hedera species. The results showed that treatment with either formaldehyde or low-light stress reduced leaf length, leaf width, stem length, stem diameter, root length and biomass, but increased leaf shape index of the two Hedera species. Treatment with formaldehyde alone increased root-shoot ratio, while treatment with formaldehyde ＋ low light or low light alone decreased root-shoot ratio of the two Hedera species. Under the stress of formaldehyde, soluble sugar content decreased, while starch content increased in roots, stems and leaves of the two Hedera species; total carbon content, proline content and carbon-to-nitrogen （C/N） ratio increased, while protein content and phosphorus content decreased in roots of the two Hedera species; the contents of total carbon, protein and total nitrogen in leaves of the two Hedera species; C/N ratio in roots of H. nepalensis increased; the C/N ratio in roots of H. nepalensis and that in leaves of the two Hedera species significantly increased. Under formaldehyde ＋ low light stress, the soluble sugar content decreased, while starch content increased in stems and leaves of the two Hedera species; starch content in roots of the two Hedera species decreased; the contents of protein and total nitrogen decreased, while C/N ratio increased in leaves of H. nepalensis ; proline content in roots and stems of the two Hedera species significantly increased.

关键词： Hedera spp. formaldehyde Weak light Growth Nutrition

Synthesis and Characterization of SnO<SUB>2</SUB>Flower-Shaped by Hydrothermal Route for formaldehyde Sensing Properties

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Advances in Materials Physics and Chemistry 2021年第4期11卷 67-77页

作者： Abeer Alhadi Shuyi Ma Shitu Pei Tingting Yang Pengdou Yun Qianqian Zhang Hamouda Adam Hamouda Li Wang Omer Almamoun Altayeb Alshiply Pengfei Cao Manahil H. Balal Khalid Ahmed Abbakar Key Laboratory of Atomic and Molecular Physics & Functional Materials of Gansu Province College of Physics and Electronic Engineering Northwest Normal University Lanzhou China College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou China Department of Chemistry Faculty of Science University of Kordofan El Obeid Sudan Faculty of Petroleum and Hydrology Engineering West Kordofan Peace University Almugled Sudan Department of Physics Faculty of Education University of Khartoum Khartoum Sudan Physics Department Faculty of Science and Art Al Baha University Gilwah KSA Department of Mathematics and Physics Faculty of Education University of Gadarif Gadarif Sudan College of Mathematics and Statistics Northwest Normal University Lanzhou China

In this work, we’ve made SnO2 flower formed with the aid of using easy test steps, and without cost, which is the hydrothermal approach and without a template. We have used a variety of techniques to characterize SnO2 flower-shaped by (SEM, TEM, XRD, BET and XPS) instruments. Confirmatory tests carried out have proven that the surface of the tetragonal structure of SnO2 has a rough surface which makes it excellent for its gas-sensing properties. The gas detection test of SnO2 flower-shaped proved that it possesses the selectivity of formaldehyde gas (about 30), the optimum operating temperature of the sensor is 220°C, and also the sensor has a high response time and recovery time is (5 s and 22 s) to 100 ppm, respectively. Particularly, the sensor has an obvious response value (2) when exposed to 5 ppm formaldehyde. As well, the mechanism of gas-sensing was also discussed.

关键词： SnO2 Flower-Shaped Hydrothermal Method formaldehyde Semiconductor Gas Sensor

Indoor Pollution in Work Office: VOCs, formaldehyde and Ozone by Printer

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Occupational Diseases and Environmental Medicine 2014年第3期2卷 49-55页

作者： Elena Barrese Angela Gioffrè Marialuisa Scarpelli Donatella Turbante Roberto Trovato Sergio Iavicoli INAIL Research Center Lamezia Terme Italy

In recent years proof of “indoor air quality”, designed to protect and improve the health and safety of workers, was a central strategy in the prevention of many companies. The man creates with the environment in which he lives and works a continuous gas exchange through breathing;this makes the respiratory system main entrance of air pollutants. The indoor pollutants are numerous and originate from different sources. Their concentration may vary over time and depends on the nature of the source, on ventilation, habits and activities carried out by the occupants in the areas concerned. It is well known that photocopiers and laser printers are equipment that emit several chemicals (ozone, solvents, toner dust) both to release the materials used for their operation (toner, ink, paper) and then to the special printing technology used. During the printing and photocopying processes occurring chemical and physical processes complex, during which the components of toner and paper will react under the influence of light and high temperatures. More recently, there have been a growing number of articles as a result of indoor air pollution. They have become more and more significant;probably because of increasing of the concentrations of harmful substances in the confined environment. Particular attention has been given to the emission of harmful substances from electronic equipment and printing that are increasingly present in living and working place. This work was the main objective the emission of volatile organic compounds, formaldehyde and ozone from laser printing devices and consequently the estimation of elimination of same substances through a paper filters which operate through a mechanism of filtration surface with interstitial and penetration of particles into matrix filter on agglomeration, they also enclose type sandwich a layer of activated carbon.

关键词： Indoor Air VOCs formaldehyde and Ozone Laser Printers

Preliminary Risk Assessment Posed by formaldehyde Residues in Clothing to Vietnamese Consumers

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Journal of Environmental Protection 2011年第4期2卷 379-386页

作者： Van Nam Thai Akihiro Tokai Osaka University Division of Sustainable Energy and Environmental EngineeringOsakaJapan

The assessment of potential health risks posed by formaldehyde in clothing to consumers is of increasing concern worldwide. Because of this, it is necessary to develop an exposure model that can realistically mimic clothes wearing conditions. This study aims to preliminarily develop a health risk assessment model for formaldehyde in clothing, and then to assess the potential health risk posed by formaldehyde in textiles to adults and infants in Vietnam using the model. Finally, this study aims to examine the plausibility of the adopted permissible values for formaldehyde in cloth- ing in Vietnam. In the model, two exposure factors for dermal exposure and overall exposure routes, i.e. sweat type and perspiration area, were considered. The margins of exposure (MOE) were calculated to estimate the health risks from worst case and average exposures. The assessment shows that acute exposure via inhalation can pose health risks to Vietnamese consumers in both cases. In regards to chronic exposure, dermal exposure is about four (for infants) and seven (for adults) times higher than exposure via inhalation, but no risks were found for average exposure. If a MOE of 100 is defined as ‘safe’ used, dermal and total chronic exposure to worst case cause potential risks, whereas no health risks were found for exposure to average case. With the model, the adopted Vietnamese permissible values for formaldehyde in clothing were assessed as not posing a health risk to Vietnamese consumers, hence they are accepted.

关键词： formaldehyde Health Risk Exposure Model Clothing Vietnamese Consumers