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Successful treatment in one myelodysplastic syndrome patient with primary thrombocytopenia and secondary deep vein thrombosis:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4640-4647页

作者： Wen-Bin Liu Jian-Xiong Ma Hong-Xuan Tong Department of Hematology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina The Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 320000Zhejiang ProvinceChina Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

BACKGROUND The contradictory process of coagulation and anticoagulation maintains normal physiological function,and platelets(PLTs)play a key role in hemostasis and *** severe thrombocytopenia and deep vein thrombosis(DVT)occur simultaneously,the physician will be confronted with a great challenge,especially when interventional thrombectomy *** SUMMARY We describe a 52-year-old woman who suffered from myelodysplastic syndrome with severe thrombocytopenia and protein S deficiency with right lower extremity *** this patient,the treatment of DVT was associated with numerous contradictions due to severe thrombocytopenia,especially when interventional thrombectomy was not ***,fondaparinux sodium effectively alleviated the thrombus status of the patient and gradually decreased the D-dimer *** addition,no increase in bleeding was *** application of eltrombopag stimulated the maturation and differentiation of megakaryocytes and increased the peripheral blood PLT *** clinical symptoms of DVT in the right lower extremities in this patient significantly *** patient resumed daily life activities,and the treatment effects were independent of PLT *** This is a contradictory and complex case,and fondaparinux sodium and eltrombopag may represent a good choice for the treatment of DVT in patients with severe thrombocytopenia.

关键词： Thrombocytopenia Deep vein thrombosis fondaparinux sodium Thrombophilia Myelodysplastic syndrome Eltrombopag Case report

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Advances in the Application of fondaparinux in Acute Coronary Syndrome

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Case Reports in Clinical Medicine 2020年第7期9卷 201-207页

作者： Lijun Jin Xue Han The First Affiliated Hospital of Yangtze University Jingzhou China Yangtze University Jingzhou China

Acute Coronary Syndrome (ACS) is one of the major causes of death worldwide, including unstable angina, ST-segment elevation myocardial infarction and NST-segment elevation myocardial infarction. ACS refers to a series of life-threatening heart diseases, which is caused by rupturing coronary plaque and releasing thrombin activation. Then thrombin is activated and generates plaque and thrombosis, which increases the risk of cardiac death and myocardial infarction. Aggressive and conservative treatment is available in clinic practice. Anticoagulant therapy is usually the first choice for conservative treatment and used in combination with dual antiplatelet drugs, which plays an important role in the treatment of acute coronary syndrome. fondaparinux as a commonly used anticoagulant drug is both antithrombotic effectively and can reduce the risk of bleeding and coronary microvascular dysfunction in the pathogenesis of ischemic heart disease. However, it increased the rate of bleeding. People pay more attention to the role of long-term prognosis. Domestic and foreign researches contrast outcomes of acute coronary syndrome of fondaparinux and low molecular weight heparin.

关键词： fondaparinux sodium Acute Coronary Syndrome Heparin

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