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Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A-Smad2/3 in rats following myocardial infarction

引用

Journal of Sport and Health Science 2021年第5期10卷 594-603页

作者： Yue Xi Meili Hao Qiaoqin Liang Yongxia Li Da-Wei Gong Zhenjun Tian Institute of Sports and Exercise Biology Shaanxi Normal UniversityXi’an 710119China School of Physical Education Luoyang Normal UniversityLuoyang 471934China School of Life Science Shaanxi Normal UniversityXi’an 710119China Division of Endocrinology Diabetes and NutritionDepartment of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Purpose:The aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1(FSTL1),which may induce cardioprotection in rats following myocardial infarction(MI)by inducing ***:Male,adult Sprague-Dawley rats were randomly divided into 5 groups(n=12 in each group):sham group(S),sedentary MI group(MI),MI+resistance exercise group(MR),MI+adeno-associated virus(AAV)-FSTL1 injection group(MA),and MI+AAV-FSTL1 injection+resistance exercise group(MAR).The AAV-FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis *** MI model was established by ligation of the left anterior descending coronary *** in the MR and MAR groups underwent 4 weeks of dynamic resistance exercise training using a weighted climbing-up *** function was evaluated by hemodynamic *** volume fraction of myocardium was observed and analyzed by Masson’s *** umbilical vein vessel endothelial cells culture and recombinant human FSTL1 protein or transforming growth factor-b receptor 1(TGFbR1)inhibitor treatment were used to elucidate the molecular signaling mechanism of ***,cell proliferation,and disco interacting protein 2 homolog A(DIP2A)location were observed by immunofluorescence *** expression of FSTL1,DIP2A,and the activation of signaling pathways were detected by Western *** of endothelial cells was observed by tubule ***-way analysis of variance and Student’s t test were used for statistical ***:Resistance exercise stimulated the secretion of skeletal muscle FSTL1,which promoted myocardial angiogenesis,inhibited pathological remodeling,and protected cardiac function in MI *** facilitated skeletal muscle FSTL1 to play a role in protecting the *** FSTL1 promoted the human umbilical vein vessel endothelial cells proliferation and up-regulated t

关键词： Angiogenesis follistatin like-1 Myocardial infarction Resistance exercise Signaling mechanism

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