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Customized and in situ fenestrated stent-grafts:A reinforced poly-ε-caprolactone branch cuff designed to prevent type III endoleaks and enhance hemodynamics

引用

Medicine in Novel Technology and Devices 2021年第1期9卷 26-36页

作者： Fujun Wang Chaojing Li Robert Guidoin Abedalwafa Mohammed Graeham Douglas Fan Zhao Guy Dionne Ze Zhang Haripriya Ramesh Lu Wang Mark Nutley Key Laboratory of Textile Science and Technology of Ministry of Education College of TextilesDonghua UniversityShanghai201620China Axe Medecine Regeneratrice Centre de Recherche du CHUand Departments of Surgery and RadiologyUniversite LavalQuebecQCCanada Department of Engineering University of CambridgeCambridgeUK Joint Department of Biomedical Engineering UNC/NCSURaleighNCUSA Division of Vascular Surgery and Department of Diagnostic Imaging University of CalgaryPeter Lougheed CentreCalgaryABCanada

Superior long-term anchorage of the bridging stent-grafts from the fenestrated main body endograft could be achieved with the addition of a flared cuff,capable of preventing the previously observed fabric fraying around the fenestration as a result of the balloon angioplasty of the seal *** novel stent cuff design will also facilitate more complete biointegration of the devices,eliminate the hemodynamic variation as well as significantly reduce the possibility of a Type III *** feasibility of this concept is demonstrated by observations made from in-situ tests performed in a Beta endograft *** cuffs made of poly(ε-caprolactone)supported with a weft-knitted polyester structure can be manufactured with various configurations to optimize the transition from the main body of the endograft,thus preventing the currently marketed designs’hemodynamic perturbation while also promoting endograft *** concept represents an evolution in branch graft design,which may enhance the long-term durability of customized fenestrations and open new applications for in-vivo graft fenestration in the near *** ongoing investigation to optimize its structure,X-ray opacity,fixation to the flared stent,and material biocompatibility are still required to build upon this concept’s proof.

关键词： flared cuff Fenestration Stent-grafts Poly(ε-caprolactone) Polyester fabrics

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