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In vitro and in vivo evaluation of micro-alloyed magnesium for potential application in alveolar bone fixation screws

引用

Journal of Materials Science & Technology 2023年第13期144卷 62-69页

作者： Hongyan Tang Qing Li Min Li Xuenan Gu Chengkung Cheng Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Center of Digital Dentistry Peking University School and Hospital of StomatologyBeijing 100081China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing 100081China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Alveolar bone augmentation with fixation screws has difficulties such as non-degradable materials that could lead to secondary surgery and insufficient osseointegration due to the subgingival environment in dental *** degradability and a high degree of osteogenesis,Mg alloy is a successful biodegrad-able material for orthopedic applications,and its application in dentistry has made certain ***-ever,considering the unique subgingival healing properties of oral implants,there is still a gap between the desired material properties for clinical applications and available ***,studies on the use of Mg-based fixation screws for dentistry applications are still *** this study,we reported a magnesium alloy with low combined addition of strontium and *** mechanical properties,degradation behavior,osteogenesis,and gingival compatibility were systematically investigated for assess-ing its potential application in alveolar bone fixation *** the alloying element content restricted to 0.3 wt.%,Mg-Sr-La alloy still exhibited good mechanical properties,with yield tensile and compressive strength twice higher than those of pure *** in vitro degradation rate of this alloy was 0.10 mm y-1,which was slightly slower than high-purity *** indirect and direct cell assay confirmed the elevated osteoblastic differentiation of MC3T3-E1 and migration of HGF-1 ***,Mg-Sr-La alloy demon-strated a relatively slow degradation in the maxillary bone of Beagles.A remarkable promotion of the bone-implant contacts and significantly decreased fibrous encapsulation was observed in the subgingival environment,implying superior osseointegration of the experimental alloy than the titanium *** empirical findings here reveal the great potential of Mg-Sr-La alloy for the application in alveolar bone fixation devices.

关键词： Magnesium alloys Alveolar ridge augmentation fixation screws Osseointegration

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