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Use of first-phase insulin secretion in Early Diagnosis of thyroid diabetes and Type 2 diabetes Mellitus

Chinese Medical Journal 2017年第7期130卷 798-804页

作者： Li-Heng Meng Yao Huang Jia Zhou Xing-Huan Liang Jing Xian Li Li Ying-Fen Qin Department of Endocrine The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China

Background：A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus （T2DM） has been ***,this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes （TDM） and ***：In total,101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance （TNGT）,hyperthyroidism with impaired glucose regulation （TIGR）,and diabetes （TDM） ***,96 patients without hyperthyroidism were recruited as control groups （normal glucose tolerance [NGT],impaired glucose regulation [IGR],and T2DM）.The following parameters were evaluated：homeostasis model assessment （HOMA）-IR,HOMA-β,modified β-cell function index （MBCI）,peak insulin/fasting insulin （IP/I0）,AUCins-OGTT,and AUCins-OGTr/AUCglu-OGTT from the oral glucose tolerance test （OGTT） insulin release test were utilized to assess the second-phase insulin secretion,while the IP/I0,AIR0＇-10＇,and AUCins-IVGTT from the intravenous glucose tolerance test （IVGTT） insulin release test were used to assess the first-phase insulin ***：In the OGTT,the HOMA-β values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups （all P 〈 0.05）.In the hyperthyroidism groups,the MBCI of the TDM group was lower than that of the TNGT and TIGR groups （all P 〈 0.05）.Among the control groups,the MBCI values of the IGR and T2DM groups were lower than that of the normal glucose tolerance （NGT） group （all P 〈 0.05）.In the IVGTT,insulin secretion peaked for all groups at 2-4 min,except for the T2DM group,which showed a low plateau and no secretion *** IPvalues of the TNGT,TIGR,and TDM groups were higher than those of the NGT,IGR,and T2DM groups （all P 〈 0.05）.The IP/I0,AIR0＇-10＇,and AUCins-IVGTT values of the TDM group were higher than those of the T2DM group but were lower than those of the TNGT,TIGR,NGR,and IGR groups （all P 〈 0.05）.Compared with the other five groups,the IP/I0 AIR0＇-10

关键词： diabetes Mellitus first-phase insulin secretion: intravenous glucose: oral glucose: thyroid diabetes

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