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Hormonal therapy might be a better choice as maintenance treatment than capecitabine after response to first-line capecitabine-based combination chemotherapy for patients with hormone receptor-positive and HER2-negative,metastatic breast cancer

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Chinese Journal of Cancer 2016年第6期35卷 46-52页

作者： Xue-Lian Chen Feng Du Ruo-Xi Hong Jia-Yu Wang Yang Luo Qing Li Ying Fan Bing-He Xu Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegePanjiayuanChaoyang DistrictBeijing 100021PRChina

Background:Both hormonal therapy(HT) and maintenance capecitabine monotherapy(MCT) have been shown to extend time to progression(TTP) in patients with metastatic breast cancer(MBC) after failure of taxanes and anthracycline?containing ***,no clinical trials have directly compared the efficacy of MCT and HT after response to first?line capecitabine?based combination chemotherapy(FCCT) in patients with hormone receptor(HR)?positive and human epidermal growth factor receptor 2(HER2)?negative breast ***:We retrospectively analyzed the charts of 138 HR?positive and HER2?negative MBC patients who were in non?progression status after FCCT and who were treated between 2003 and 2012 at the Cancer Institute and Hospital,Chinese Academy of Medical Sciences,in Beijing,*** median number of first?line chemotherapy cycles was 6(range,4–8);combined agents included taxanes,vinorelbine,or *** these 138 patients,79 received MCT,and 59 received ***?agent capecitabine was administered at a dose of 1250 mg/m2 twice daily for 14 days,followed by a 7?day rest period,repeated every 3 *** the 59 patients who received HT,37 received aromatase inhibitors(AIs),8 received selective estrogen receptor modulators(SERMs),and 14 received goserelin plus either AIs or *** then compared the MCT group and HT group in terms of treatment ***:With a median follow?up of 43 months,patients in the HT group had a much longer TTP than patients in the MCT group(13 vs.8 months,P ease?free surviv= 0.011).When TTP was adjusted for age,menopausal status,Karnofsky performance status score,disal,site of metastasis,number of metastatic sites,and response status after FCCT,extended TTP was still observed for patients in the HT group(hazard ratio:0.63;95% confidence interval:0.44–0.93;P = 0.020).We also observed a trend of overall survival advantage for patients in the HT group *** in the MCT group,but the difference was not significant(43 vs.37

关键词： Hormonal therapy Maintenance capecitabine monotherapy first-line capecitabine-based combination chemotherapy Metastatic breast cancer

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