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Feasibility of Transabdominal Real-time CDFI and HDFI Techniques for Fetal Pulmonary Vein Display in the first trimester

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Current Medical Science 2022年第3期42卷 635-641页

作者： Dong-mei LIN Yun-xiao ZHU Ying TAN Yu-jun HUANG Kun YUAN Wen-fen LIU Zuo-feng XU Department of Medical Ultrasonics the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of Medical Ultrasonics South China Hospital of Shenzhen UniversityShenzhen 518000China

Objective This study aimed to assess the feasibility and usefulness of transabdominal color Doppler flow imaging(CDFI)technology and the high-definition flow imaging(HDFI)technique in detecting fetal pulmonary veins(PVs)in the first trimester(11–13^(+6)weeks).Methods From December 2018 to October 2019,328 pregnant women with 328 normal singleton fetuses(crown-rump length:45–84 mm)who had undergone CDFI and HDFI scans for fetal heart and vessel examination were enrolled in this study.The cases were divided into three groups according to the gestational age:group A,11^(+0)−11^(+6)weeks;group B,12^(+0)−12^(+6)weeks;and group C,13^(+0)−13^(+6)weeks.Baseline sonograms and CDFI and HDFI images were analyzed by two senior radiologists independently and blindly.The abilities of CDFI and HDFI to display PVs were compared.Results Successful PV display rates via CDFI and HDFI were 2.3%and 68.2%(P<0.01),22.4%and 82.4%(P<0.01),41.5%and 91.2%(P<0.01)for group A,group B,and group C,respectively.The total successful display rates for the two methods were 28.9%(CDFI)and 84.8%(HDFI)(P<0.01).Conclusions The HDFI technique is more valuable than CDFI for detecting PVs in early pregnancy(11–13^(+6)weeks).HDFI can detect at least one PV in all cases and may be used to detect pulmonary venous anomalies early.

关键词： pulmonary vein first trimester prenatal sonography high-definition flow imaging color Doppler flow imaging

Lower uterine segment pregnancy with placenta increta complicating first trimester induced abortion: diagnosis and conservative management

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Chinese Medical Journal 2003年第5期116卷 695-698页

作者：刘欣燕范光升金征宇杨宁姜玉新盖铭英郭丽娜王友芳郎景和 Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100730 China

r Objective To discuss the diagnosis of and conservative management for lower uterine segment pregnancy with placenta increta complicating first trimester abortion. Methods Four patients with previous caesarean section and severe hemorrhage in induced abortion in the first trimester were studied. Uterine artery embolization (UAE) was used to control bleeding and preserve the uterus. Results UAE controlled heavy uterine bleeding satisfactorily. One of the four patients asked for a hysterectomy after UAE, and her pathology report confirmed “lower uterine segment pregnancy with placenta increta”. Conclusion Previous caesarean section is a risk factor for lower uterine segment pregnancy with placenta increta. UAE is one of the best conservative management methods for heavy hemorrhage, especially for women who desire future fertility.

关键词： pregnancy first trimester induced abortion diagnosis therapeutic embolization

Ultrasound screening of fetal structural abnormalities by standard ultrasound views during the first trimester

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Chinese Medical Journal 2013年第5期126卷 986-987页

作者： WANG Li WU Qing-qing CHEN Yan MA Yu-qing YAO Ling LI Man Department of Ultrasound Beijing Obstetrics and GynecologyHospital Capital Medical University Beijing 100026 China School of Public Health and Family Medicine Capital MedicalUniversity Beijing 100069 China

In China, ultrasound screening of fetal abnormalities is usually performed at 20 to 24 weeks of gestation.Recent data suggest that many fetal abnormalities can be detected as early as 11 to 14 weeks of gestation.l In this study, we applied standard ultrasound views to screen for fetal structural abnormalities during the first trimester and investigated the effectiveness of the standard ultrasound views in the detection of fetal abnormalities.

关键词： first trimester ultrasound fetus fetal abnormalities

Application of Short Tandem Repeat in Prenatal Diagnosis for Phenmylketonuria during the first trimester

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Journal of Nanjing Medical University 2003年第2期17卷 58-61页

作者：赵晓岚叶国玲楚雍烈刘琪蔡晓宁李明丽 DepartmentofMedicalGenetics theSecondHospitalofXi‘anJiaotongUniversityXi’an710004P.R.China

Objective : To find a simple and rapid way far the prenatal diagnosis of phenyUce-tonuria (PKU) during the first trimester in order to prevent inborn PKU patients as early as possible. Methods :DNA was extracted respectively from the Mood sampleps of 9 families' members and chori-onic tissues of 9 embryoes by cliorionic vittus sampling (CVS). The independent short tandem repeat (STR) alleles of members in 9 families with classic form of PKU were analyzed and prenatal diagnosis were conducted using polymerase chain reaction (PCR) together with denaturing gradient gel elec-trophoresis(DGGE)and silver dyeing. Results-.We identified 1 embryo with PKU, 2 normal individuals and 5 carriers among 9 subjects. Conclusion: Prenatal diagnosis for PKU by STR is available in the first trimester. This procedure was promising and would be widely used in Chinese population.

关键词： prenatal diagnosis phenylketonuria short tandem repeat first trimester

Screening and Prevention of Preeclampsia

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Maternal-Fetal Medicine 2019年第1期1卷 25-30页

作者： Liona C.Poon Daljit Sahota Department of Obstetrics and Gynaecology The Chinese University of Hong KongShatinHongKong 999077China

Preeclampsia(PE)is a multisystem disorder of pregnancy classically characterized by hypertension with significant proteinuria after 20 weeks'gestation.This disorder is one of the leading causes of maternal and perinatal morbidity and mortality.PE can be subdivided into preterm PE(with delivery at<37 weeks'gestation)and term PE(with delivery at≥37 weeks'gestation).Preterm PE is associated with a higher risk of adverse maternal and perinatal outcomes than term PE.Traditional method of screening as recommended by professional guidelines has limited predictive performance and therefore should be updated to reflect recent scientific evidence that the target of screening should be preterm PE,the best way to identify the high-risk group is the Bayes-based method that combines maternal risk factors and biomarkers,the threshold should be set at screen positive rate of 10%,aspirin should be started before 16 weeks'gestation,and the daily dose should be higher than 100mg.

关键词： Preeclampsia first trimester Screening Mean arterial pressure Uterine artery pulsatility index Placental growth factor

早期妊娠妇女胎盘绒毛滋养层组织蛋白质的生化分析

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中华生殖与避孕杂志 1986年第4NO.03NO.02NO.01期 10-14页

作者：曹詠清郑明陈幼珍中国科学院动物研究所内分泌室

本研究对不同周数(6、7、8、9、10周)妊娠妇女胎盘绒毛滋养层组织水溶性蛋白质组分、分子量、等电点及其特性进行了分析和比较。用SDS-聚丙烯酰胺凝胶电泳分析结果指明,妊娠早期绒毛组织,除分泌绒毛膜促性腺激素(hCG)这一含量较多的蛋... 详细信息

本研究对不同周数(6、7、8、9、10周)妊娠妇女胎盘绒毛滋养层组织水溶性蛋白质组分、分子量、等电点及其特性进行了分析和比较。用SDS-聚丙烯酰胺凝胶电泳分析结果指明,妊娠早期绒毛组织,除分泌绒毛膜促性腺激素(hCG)这一含量较多的蛋白以外,尚含有其他四种含量较高的蛋白质,这四种蛋白质的分子量分别为:140,000,128,000,94,000和83,000左右。用高压液相色谱层析和等电聚焦电泳分析结果指明,在不同周龄的组织中其蛋白量和组分间的比例稍有变化,较多的蛋白质为酸性蛋白,与蜕膜组织蛋白质组分作比较,绒毛组织具有蜕膜组织内不存在的蛋白组分,其等电点分别为:8.4、6.4、5.8、4.8。由此可知早期妊娠胎盘绒毛滋养层组织,存在一些含量较高的特殊蛋白,深入研究这些蛋白的特性和生理功能,将对阐明人类妊娠生理和寻找控制生育新途径有重要意义。

关键词： Trophoblast Decidua first trimester Isoelectric focusing Isoelectric point

Clinical Application of Massively Parallel Sequencing of Maternal Plasma to Detect Fetal Chromosome Abnormalities

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Clinical Application of Massively Parallel Sequencing of Mat...