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Gingival fibromatosis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1996年第1期16卷 55-57页

作者：陈卫民陈新明 Department of Stomatology Tongji Hospital Tongji Medical University Wuhan Department of Pathology College of Somatology Hubei Medical University Wuhan

Presented in this paper is a clinico-pathological report of 11 cases of gingival fibromatosis. Of the 11 patients in our series, 2 cases (18.2%) with family history began to have symptom from age of 3, which is manifested by the involvement of whole gum. 9 patients (81.8%), for which the etiology was unknown, had onset of the disease at the periods of deciduous dentition, mixed dentition or permanent dentition, with localized or overall involvement of gingiva. The disease is characterized by diffuse or localized proliferation of gum. Microscopically, the proliferating gum tissue revealed well-developed fibrotic structure with few cells; and the fibers were densely arranged without clear boundary. The fibrotic tissues showed a diminishing of blood vessels and the infiltration of inflammatory cells is not conspicuous.

关键词： gingival fibromatosis family

1 Case Clinical Report of Cranium Aggressive fibromatosis and Literature Review

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International Journal of Clinical Medicine 2015年第10期6卷 734-739页

作者： Qi Yan Ming Li Jintao Li No. 2 Neurosurgery Department 1st Affiliated Hospital of Kunming Medical University Yunnan China Neuroscience Institute of Kunming Medical University Yunnan China

Objective: The purpose of this study is to explore the clinical characteristics and therapeutic methods of aggressive fibromatosis (AF) in skull. Methods: The clinical data and operative therapy of one case of aggressive fibromatosis in skull in our department were examined and reviewed. The associated literatures were reviewed and discussed. Results: It was indicated that the main manifestation of AF in skull was headache and skull tumor. There was prominent osteolytic destruction found in X-ray plain film for skull AF. And CT scanning showed that skull sclerotin was disorganized and inhomogeneous, with widen diploe. The skull fibromatosis constituted by fibroblasts and myofibroblas, which were mainly spindle-shaped without heteromorphism. Immunohistochemistry showed positive expression of β-catenin and Vim in these cells. The enlarged incision was adopted for the strategy of operation in this patient of skull AF. After follow-up, there was no recurrence of AF discovered. Conclusions: Skull AF is very rare in neurosurgical clinic. The clinical manifestation and iconography of AF were lack of specificity. Therefore, skull AF is hard to diagnose preoperatively. The effective diagnose is mainly dependant on histopathologic examination. As for treatment, operation is the most optimal method so far, which has a good therapeutic effect.

关键词： Skull Aggressive fibromatosis Operation

Primary fibromatosis of the breast in a 13 years old girl

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 206-209页

作者： Elhassani Mehdi Kouach Jaouad Achenani Mouna Babahabib Abdellah Moussaoui Driss Dehayni Mohamed Bakkali Hicham Anesthesiology Department ElRapaha Polyclinic Libreville Gabon Gynecology-Obstetrics Departement Mohamed V Military Hospital for Instruction Rabat Morocco Gynecology-Obstetrics Department ElRapaha Polyclinic Libreville Gabon Gynecology-Obstetrics Department Mohamed V Military Hospital for Instruction Rabat Morocco

The mammary fibromatosis is a rare clinical entity. The etiopathogeny remains unclear. The clinical and radiological characteristics of this injury are often worrying within the main differential diagnosis of the mammary carcinoma;however only the histological examination can confirm the diagnosis. It is characterized by a strictly local evolution with an infiltration and recidivism tendancy without giving metastasis. The treatment is basically surgical. We report here-with an observed case of 13-year-old girl, presenting with a huge tumor located in the left breast with ulceration of the nipple-areolar plate. The diagnosis is confirmed by the histological study. The treatment consisted of a mastectomy. Suites are simple. In view of the clinical evidence of the literature, we call back the difficulties of management of this tumor.

关键词： Breast fibromatosis Desmoid tumor Extraabdominal Desmoid Tumors Gardner’s Syndrome

Giant mesenteric fibromatosis:Report of a case and review of the literature

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World Journal of Gastrointestinal Surgery 2012年第3期4卷 79-82页

作者： Mohammed Khalid Mirza Gari Salman Yousuf Guraya Amir Mounir Hussein Moustafa Mahmoud Nafady Hego Department of Surgery Imam Abdulrehman Bin Faisal HospitalNational Guard Health Affairs Department of Surgery Taibah UnivesrityMinistry of Higher Education

Mesenteric fibromatosis poses a diagnostic and therapeutic *** paper presents a 35-year-old female complaining of vague abdominal pain of 2 mo *** computed tomography scan and magnetic resonance imaging revealed a pelvi-abdominal heterogenous mass with significant displacement of the small bowel and urinary *** underwent surgical excision of the mass with resection and anastomosis of the involved loop of the small *** examination confirmed mesenteric fibromatosis without infiltration of the *** patient remained well during the 6 mo follow-up.

关键词： Desmoid tumors Mesenteric fibromatosis Radiotherapy

A case report on aggressive fibromatosis of the arm and shoulder

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Discussion of Clinical Cases 2020年第4期7卷 1-3页

作者： Sameh Hany Emile Ahmad Sakr Department of General Surgery Mansoura Faculty of MedicineMansoura UniversityEgypt

Background:Aggressive fibromatosis is a locally aggressive tumor that originates from the deep musculo-aponeurotic *** this report,we describe the case of an adolescent male with painless,progressively growing swelling in his right arm necessitated surgical excision and postoperative pathologic examination revealed aggressive *** presentation:A 15-year-old boy presented with a painless,progressively growing swelling of his right *** swelling was firm,non-tender and with restricted *** imaging revealed a well-defined,heterogenous,lobulated swelling extending beneath arm and shoulder *** local excision of the swelling was done under general anesthesia and pathologic examination revealed aggressive fibromatosis of the *** radiotherapy was provided to the patient to reduce the risk of local recurrence of the ***:Aggressive fibromatosis of the upper limb presents as a painless,progressively growing *** with MRI is imperative for making a preliminary *** local excision with safety margin with adjuvant radiotherapy is the main line of treatment to minimize the incidence of recurrence and preserve the limb.

关键词： Aggressive fibromatosis Arm Shoulder Case report

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腹壁侵袭性纤维瘤病1例报告并文献复习

基层医学论坛 2014年第1期18卷 10-12页

作者：姚宗浠刘玉林葛建明苏州市吴中人民医院江苏苏州215128

目的探讨侵袭性纤维瘤病的临床、病理、影像学特征及治疗方法。方法报告1例腹壁侵袭性纤维瘤病病例,结合文献探讨该病的临床特点、影像学特征、病理学表现、治疗及预后。结果侵袭性纤维瘤病在临床上较为少见,表现为向周围组织侵袭生长... 详细信息

目的探讨侵袭性纤维瘤病的临床、病理、影像学特征及治疗方法。方法报告1例腹壁侵袭性纤维瘤病病例,结合文献探讨该病的临床特点、影像学特征、病理学表现、治疗及预后。结果侵袭性纤维瘤病在临床上较为少见,表现为向周围组织侵袭生长的包块,无包膜,界限不清,活动度差。影像学检查无特异性,难以与其他软组织肿瘤相鉴别。病理学特点:主要由梭形的纤维母细胞和肌纤维母细胞呈束状排列,无明显异型性,核分裂象少。本病易复发,手术治疗应彻底,放疗对肿瘤局部控制及降低复发率有一定作用,同时还有化疗和内分泌等治疗方法。结论侵袭性纤维瘤病是一种局部侵袭性较强的病变,应结合临床表现、CT、MRI及病理学特点诊断本病。治疗关键为首次手术切除范围需广泛,切缘距瘤缘3 cm以上,使切缘完全阴性。放疗可局部控制肿瘤生长及降低复发率。

关键词：侵袭性纤维瘤病临床特点影像学特征病理学表现治疗及预后 Aggressive fibromatosis (AF)

Mandibular Reconstruction in Cervical Desmoid Tumors

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Open Journal of Pediatrics 2021年第3期11卷 398-405页

作者： Ayoub Boutahar Imane Oualili Abdelhalim Mahmoudi Khalid Khattala Youssef Bouabdallah Department of Pediatric Surgery Faculty of Medicine and Pharmacy of Fez University Hospital Center Hassan II Fes Morocco

Introduction: Desmoid tumors are benign soft tissue tumors, but their infiltration character is responsible for big morbidity, especially in the cervicofacial location. Their management, therefore, represents a real challenge. Clinical case: Reporting a case of a 4-year-old girl presenting a desmoid tumor at the expense of the mandibular corpus and the right ascending ramus, with loco-regional infiltration, and whose treatment consisted of surgical resection of the tumor with Hemi-mandibulectomy and reconstruction according to the Masquelet technique. Conclusion: The traditional treatment consists of a large local excision with negative surgical margins. Head and neck fibromatosis, while rare, present a complex problem as they are often aggressive, and invade local bone, nerve and muscles, and can leave patients with a cosmetic deformity. In our case, it was a mandibular reconstruction after a large resection of a desmoid tumor with a location on the head and neck. With good consolidation, absence of recurrence, and without aesthetic sequelae at the control.

关键词： Desmoid Tumor fibromatosis Surgery Masquelet

Sporadic Desmoid Tumor of the Small Bowel Mesentery in a Male Patient: A Case Report and Literature Review

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Journal of Cancer Therapy 2014年第11期5卷 1000-1004页

作者： Lamiae Amaadour Zineb Benbrahim Khadija Benhayoune Layla Chbani Samia Arifi Nawfel Mellas Department of Medical Oncology Hassan II University Hospital Fez Morocco Department of Pathology Hassan II University Hospital Fez Morocco

Aggressive fibromatosis arising from the small bowel mesentery is extremely rare. It may occur in association with previous trauma, abdominal surgery, drugs, Gardner’s syndrome, or familial adenomatous polyposis. This paper presents a 32-year-old man with no significant medical or surgical history, complaining of diffuse abdominal pain and discomfort. His computed tomography scan revealed a well-defined soft tissue mass in the peritoneal cavity. He underwent surgical excision of the mass with resection and anastomosis of the involved loop of the small intestine. Histological examination confirmed mesenteric fibromatosis without infiltration of the bowel. The patient remained well during the 8 months follow-up.

关键词： Desmoid Tumor Mesenteric fibromatosis Surgery

Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review

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World Journal of Clinical Oncology 2019年第4期10卷 183-191页

作者： Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department ofSurgery National and Kapodistrian University of Athens Laikon Hospital Department of Radiology National and Kapodistrian University of Athens Laikon Hospital 1st Department of Pathology National and Kapodistrian University of Athens

BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with *** SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease ***'s pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used.

关键词： Desmoid tumor Aggressive fibromatosis Case report Pathogenesis Therapeutic approach Sorafenib treatment