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The Reliability of fibro-test in Staging Orthotopic Liver Transplant Recipients with Recurrent Hepatitis C

Journal of Clinical and Translational Hepatology 2020年第1期8卷 9-12页

作者： Panagiotis Trilianos Adamantios Tsangaris Augustine Tawadros Vrushak Deshpande Nikolaos Pyrsopoulos Division of Gastroenterology&Hepatology University HospitalRutgers-New Jersey Medical SchoolNJUSA

Background and Aims:Liver biopsy remains the gold stand-ard for staging of chronic liver disease following orthotopic liver *** assessment of fibrosis with fibro-test(FT)is well-studied in immunocompetent populations with chronic hepatitis C virus *** aim of this study is to investigate the diagnostic value of FT in the assessment of hepatic fibrosis in the allografts of liver transplant recipients with evidence of recurrent hepatitis ***:We retro-spectively compared liver biopsies and FT performed within a median of 1 month of each other in orthotopic liver transplan-tation recipients with recurrent hepatitis ***:The study population comprised 22 patients,most of them male(19/22),and with median age of 62 *** all patients,there was at least a one-stage difference in fibrosis as assessed by liver biopsy compared to FT,while for the majority(16/22)there was at least a two-stage *** absence of correlation between the two modalities was statistically demonstrated(Mann-Whitney U test,p=0.01).In detecting significant fib-rosis(a METAVIR stage of F2 and above),an FT cut-off of 0.5 showed moderate sensitivity(77%)and negative predictive value(80%),but suboptimal specificity(61%)and positive predictive value(58%).Conclusions:In post-transplant pa-tients with recurrent hepatitis C,FT appears to be inaccurately assessing the degree of allograft fibrosis,therefore limiting its reliability as a staging tool.

关键词： fibro-test Orthotopic liver transplantation fibrosis Recurrent hepatitis C Hepatitis C virus

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