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*** in the monkey retina in response to moderate fetal alcohol exposure

Annals of Eye Science 2018年第1期 455-455页

作者： Joseph Bouskila Ryan Kucera Clara Eid Jean-François Bouchard Roberta Palmour Maurice Ptito Department of Psychiatry and Human Genetics McGill UniversityMontrealQCCanada St-Kitts Behavioural Science Foundation St-Kitts and NevisWest Indies School of Optometry University of MontrealMontrealQCCanada Laboratory of Neuropsychiatry Psychiatric Centre CopenhagenDenmark

Background:exposure to ethanol in utero leads to several brain development disorders including retinal abnormalities whose underlying cellular pathogenesis remains *** have previously reported changes in electroretinogram recordings in moderate fetal alcohol exposure(MFAE)vervet *** goal of this study is to characterize the anatomical effects of moderate MFAE during the third trimester in the vervet monkey ***:Using immunohistochemistry and Western blots,we analyzed changes in the expression of cell-type specific proteins that may occur in the MFAE retina compared to the normal *** also compared the basic retinal anatomy across groups by examining retinal layering and ***:Our main result indicates that GFAP(a potent marker of astrocytes)immunoreactivity was increased in the MFAE retina indicating strong *** was no obvious change in the overall anatomy in the MFAE retina and no significant differences in the mean thickness of each retinal ***,no significant changes in the morphology of the photoreceptors,horizontal cells,bipolar cells,and amacrines cells was ***:These data indicate that astrogliosis is a consequence of prenatal alcohol exposure and might explain the reported changes in the electroretinographic responses.

关键词： fetal alcohol exposure astrogliosis retina monkeys immunohistochemistry

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