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Dietary N-carbamylglutamate or L-arginine improves fetal intestinal amino acid profiles during intrauterine growth restriction in undernourished ewes

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Animal Nutrition 2022年第1期8卷 341-349页

作者： Hao Zhang Xiaoyun Liu Yi Zheng Ying Zhang Juan J.Loor Hongrong Wang Mengzhi Wang State Key Laboratory of sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation ScienceShihezi 832000China Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China Department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA

Our previous studies demonstrated that prenatal in utero growth restriction impairs postnatal intestinal ***,improving postpartal intestinal absorption capacity and growth by manipulating the maternal diet prepartum is of *** work was conducted to determine whether supplementation of N-carbamylglutamate(NCG)or rumen-protected L-arginine(RP-Arg)increased fetal intestinal amino acid(AA)profiles in intrauterine growth retardation(IUGR)*** d 35 of gestation,Hu ewes(n=32)carrying twin fetuses were randomized into 4 groups(8 ewes and 16 fetuses in each group),where diets were as follows:100%of nutrient requirements recommended by National Research Council(NRC,2007)(CON);50%of nutrient requirements recommended by NRC(2007)(RES);RES+RPArg(20 g/d),(RES+ARG);and RES+NCG(5 g/d),(RES+NCG).On d 110 of gestation,both fetal and maternal tissues were collected and *** with RES,solute carrier family 1,member 5(SLC1A5)was upregulated(Pfetal jejunum,duodenum and ileum when supplementing NCG and *** to RES,RP-Arg or NCG supplementation to RES resulted in upregulation(Pfetal *** or RP-Arg supplementation to RES also upregulated phosphorylated mechanistic target of rapamycin(pmTOR)-to-mTOR ratio in the fetal ileum induced by IUGR(Pfetal *** would help demonstrate the relative contribution of intestinal uptake in fetal life.

关键词： Intrauterine growth restriction L-arginine fetal sheep N-carbamylglutamate Intestinal amino acids

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Dietary rumen-protected L-arginine or N-carbamylglutamate attenuated fetal hepatic inflammation in undernourished ewes suffering from intrauterine growth restriction

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Animal Nutrition 2021年第4期7卷 1095-1104页

作者： Hao Zhang Ying Zhang Yi Ma Mabrouk Elsabagh Hongrong Wang Mengzhi Wang State Key Laboratory of sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural Reclamation SciencesShihezi832000China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou225009China Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou225009China Department of Animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityNigde51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelsheikh33516Egypt

This study aimed to explore whether dietary rumen-protected L-arginine(RP-Arg)or N-carbamylglutamate(NCG)supplementation to feed-restricted pregnant ewes counteracts fetal hepatic inflammation and innate immune dysfunction associated with intrauterine growth retardation(IUGR)in ovine *** d 35 of pregnancy,twin-bearing Hu ewes(n=32)were randomly assigned to 4 treatment groups(8 ewes and 16 fetuses per group)and fed diets containing 100%of the NRC requirements(CON),50%of the NRC requirements(RES),RES+RP-Arg(20 g/d)(RESA),or RES+NCG(5 g/d)(RESN).At 08:00 on d 110 of gestation,fetal blood and liver tissue samples were *** levels of triglyceride,free fatty acid,cholesterol andβ-hydroxybutyrate in the fetal blood of RESA and RESN groups were lower(Pfetal blood and liver tissue as well as the myeloid differentiation primary response 88(MyD88),transforming growth factorβ(TGFβ),and nuclear factor kappa B(NF-κB)mRNA levels in the fetal liver were decreased(Pfetal liver were reduced(Pfetal hepatic inflammation via improving lipid metabolism,down-regulating the TLR-4 and the inflammatory JNK and NF-icB signaling pathways,and decreasing cytokine production in ovine fetal blood and liver tissue.

关键词： L-arginine fetal sheep Liver inflammation Intrauterine growth restriction N-carbamylglutamate

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