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fermented psidium guajava leaves regulate the gut microbiota and improve metabolic alterations in diabetic mice

Food Bioscience 2023年第1期51卷 220-234页

作者： Zhenfeng Huang Zheng Fang Anping Wu Fei Shen Zhenqiang Wu School of Biology and Biological Engineering South China University of TechnologyGuangzhou510006PR China Pan Asia(Jiangmen)Institute of Biological Engineering and Health Jiangmen529080PR China

The phenolic extract from fermented psidium guajava leaves(PFGL)helps to improve diabetes;however,its hypoglycemic and hypolipidemic mechanisms remain *** this study,gut microbiota modulation and glucose-lipid metabolism was *** results showed that dietary supplement of PFGL enriched in quercetin glucosides significantly improved serum glucose-lipid profiles as well as insulin resistance in diabetic *** gut microbiota of diabetic mice was modulated by PFGL(200 mg/kg),causing an abundance of Bacteroidetes,Prevotellaceae,and Alistipes and a reduced the presence of Firmicutes and *** levels of short-chain fatty acids(SCFA)activated G protein-coupled receptor signaling that induced peptide YY release to promote insulin ***-induced serum metabolite disorders that are involved in glycerophospholipid metabolism and tryptophan metabolism were restored by *** protein expression of metabolic enzymes including phospho-adenosine 5’-monophosphate-activated protein kinase,fatty acid synthase,acyl-coenzyme A oxidase,and diacylglycerol aeyltransferase 2 were also regulated to promote glucoselipid *** particular,gut microbiota enriched with Alistipes genera and SCFA metabolic regulation were closely correlated with diabetes-related *** findings provide a theoretical support for the development and application of PFGL for the treatment of diabetes.

关键词： fermented psidium guajava leaves Phenolic extract Gut microbiota Host metabolism Hypoglycemic Hypolipidemic

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