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Development of an intelligent heterojunction fenton catalyst for chemodynamic/starvation synergistic cancer therapy

Journal of Materials Science & Technology 2023年第10期141卷 11-20页

作者： Weishu Ni Ke Jiang Qiaomei Ke Jia Su Xianying Cao Ling Zhang Chunxia Li Key Laboratory of Food Nutrition and Functional Food of Hainan Province School of Food Science and EngineeringHainan UniversityHaikou 570228China Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China State Key Laboratory of Silicon Materials Zhejiang UniversityHangzhou 310027China

Chemodynamic therapy(CDT)as an emerging modality in cancer treatment,its implementation remains a daunting challenge by the lack of smart fenton catalyst under acidic tumor ***,we have successfully constructed a Fe_(3)O_(4)@MIL-100 heterojunction by growing Fe-based metal-organic framework(MIL-100)onto the surface of Fe_(3)O_(4) *** as-made heterojunction after encapsu-lating glucose oxidase(termed FMG)is demonstrated as a pH-responsive intelligent fenton nanosystem with the synergistic effect of starvation therapy(ST).Density functional theory(DFT)calculations reveal that such heterojunction could greatly reduce the energy barrier of the fenton reaction,which better ex-plains the mechanism of fenton performance ***,the encapsulated glucose oxidase has successfully activated the ST process,in which its generated H_(2)O_(2) and gluconic acid further improve the CDT *** O_(2) from the enhanced CDT in turn promotes the enzymatic reaction of glucose *** fenton/cascade enzymatic reaction operates in a self-feedback manner as *** vitro and in vivo experiments demonstrate that such intelligent fenton nanoreactors provide a powerful anti-cancer mechanism for effective tumor ablation with enough *** work provides insights into the developments of MOF-based heterojunctions as powerful anticancer treatment nanoreactors.

关键词： Heterostructure Metal-organic framework fenton catalyst Chemodynamic therapy Starvation therapy

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Hydroxyl radical-involved cancer therapy via fenton reactions

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Frontiers of Chemical Science and Engineering 2022年第3期16卷 345-363页

作者： Mengying Liu Yun Xu Yanjun Zhao Zheng Wang Dunyun Shi School of Pharmaceutical Science&Technology Tianjin UniversityTianjin300072China Central Lab Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen UniversityShenzhen518035China Institute of Hematology Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen UniversityShenzhen518035China

The tumor microenvironment features over-expressed hydrogen peroxide(H_(2)O_(2)).Thus,versatile therapeutic strategies based on H_(2)O_(2) as a reaction substrate to generate hydroxyl radical(•OH)have been used as a prospective therapeutic method to boost anticancer ***,the limited fenton catalysts and insufficient endogenous H_(2)O_(2) content in tumor sites greatly hinder•OH production,failing to achieve the desired therapeutic ***,supplying fenton catalysts and elevating H_(2)O_(2) levels into cancer cells are effective strategies to improve•OH *** therapeutic strategies are systematically discussed in this ***,the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed to improve therapeutic efficacy.

关键词： hydroxyl radical fenton catalyst hydrogen peroxide cancer therapy

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