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Biomedical and Environmental Sciences 2012年第5期25卷 577-582页

作者： Natalia LANOCHA Elzbieta KALISINSKA Danuta KOSIK-BOGACKA Halina BUDIS Sebastian SOKOLOWSKI Andrzej BOHATYREWICZ Department of Biology and Medical Parasitology Pomeranian Medical University Clinic of Orthopedics and Traumatology Pomeranian Medical University

Abstract Objective To determine the concentrations of lead （Pb） and cadmium （Cd） in three kinds of materials （cartilage, cortical bone, and cancellous bone） of the femur head obtained from patients in the process of operation. Methods Concentrations of Pb and Cd were determined in selected parts of the femur head of 30 patients after total hip arthroplasty, using ICP-AES （atomic absorption spectrophotometry）. Results Pb contained the highest concentration in cortical bone, while Cd did so in cancellous bone. There were statistically significant differences in the concentrations of both elements between the cartilage and cortical bone, and also differences in the concentration of Pb between the cartilage and cancellous bone. There were no significant differences in the concentrations of Pb or Cd between cortical and cancellous bone. Conclusion Comparative studies on toxic metals should take into account both analogous bones and their fragments, as even if they come from the same kind of bones （e.g. femur head）, clear differences exist in concentrations of heavy metals related to the sampling site and type of tissue （cartilage, cortical bone, and cancellous bone）.

关键词： femur head Heavy metals Cartilage Cortical bone Cancellous bone

Chromium Content in the Human Hip Joint Tissues

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Biomedical and Environmental Sciences 2015年第2期28卷 89-96页

作者： Barbara Brodziak-Dopiera?a Jerzy Kwapuliński Krzysztof Sobczyk Danuta Wiechu?a School of Pharmacy with the Division of Laboratory Medicine Department of Toxicology Medical University of Silesia Institute of Occupational Medicine and Environmental Health Municipal Hospital Department of Traumatic Surgery

Objective Chromium has many important functions in the human body. For the osseous tissue, its role has not been clearly defined. This study was aimed at determining chromium content in hip joint tissues. Methods A total of 91 hip joint samples were taken in this study, including 66 from females and 25 from males. The sample tissues were separated according to their anatomical parts. The chromium content was determined by the AAS method. The statistical analysis was performed with U Mann-Whitney＇s non-parametric test, P〈0.05. Results The overall chromium content in tissues of the hip joint in the study subjects was as follows： 5.73 μg/g in the articular cartilage, 5.33 μ/g in the cortical bone, 27.86 μ/g in the cancellous bone, 5.95 μg/8 in the fragment of the cancellous bone from the intertrochanteric region, and 2.28 μ/g in the joint capsule. The chromium contents were observed in 2 group patients, it was 7.04 μ/g in people with osteoarthritis and 22.59 μ/g in people with fractures. Conclusion The observed chromium content was highest in the cancellous bone and the lowest in the joint capsule. Chromium content was significantly different between the people with hip joint osteoarthritis and the people with femoral neck fractures.

关键词： Chromium femur head Hip joint Cortical bone Cancellous bone

Femoral head fracture without hip dislocation

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Chinese Journal of Traumatology 2013年第5期16卷 304-307页

作者： Aditya K Aggarwal Ashwani Soni Daljeet Singh Department of Orthopaedic Surgery Postgraduate Institute of Medical Education & Research Chandigarh India

Femoral head fractures without disloca- tion or subluxation are extremely rare injuries. We report a neglected case of isolated comminuted fracture of femoral head without hip dislocation or subluxation of one year duration in a 36-year-old patient who sustained a high en- ergy trauma due to road traffic accident. He presented with painful right hip and inability to bear full weight on right lower limb with Harris hip score of 39. He received cementless total hip replacement. At latest follow-up of 2.3 years, functional outcome was excellent with Harris hip score of 95. Such isolated injuries have been described only once in the literature and have not been classified till now. The purpose of this report is to highlight the extreme rarity, pos- sible mechanism involved and a novel classification system to classify such injuries.

关键词： femur head Hip dislocation Classification Arthroplasty, replacement, hip

Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion

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Chinese Journal of Traumatology 2006年第1期9卷 3-7页

作者：阎作勤陈云苏李文俊杨轶霍建忠陈峥嵘史剑慧葛均波 Department of Orthopaedics Zhongshan Hospital of Fudan University Shanghai 200032 China Department of Cardiology Zhongshan Hospital of Fudan University Shanghai 200032 China

Objective： To evaluate the clinical efficacy and safety of the treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell （BMCs） infusion. Methods： 44 hips in 28 patients with avascular necrosis at early stage were treated by percutaneous multiple holes decompression followed by autologous BMCs infusion. Autologous BMCs were concentrated from bone marrow that was taken from the posterior iliac crest of the patient. Patients were followed up at least 2 years. The results were determined by the changes in the Harris hip score and the progression in the radiograghic stages. Results： No complications were observed after the operation. Before operation, there were stage Ⅰ of femoral head necrosis in 8 hips, stage Ⅱin 15 hips, stage Ⅲin 14 hips, stage Ⅳ in 7 hips, and the postoperative stages at the most recent follow-up were stage O in 1 hip, stage Ⅰ in 6 hips, stage Ⅱin 13 hips, stage Ⅲin 13 hips, stage Ⅳ in 7 hips, stage Ⅴ in 4 hips. The mean preoperative Harris hip score was 58 （ 46-89 ）, and improved to 86 （ 70-94 ） postoperatively. All the femoral head collapsed preoperatively showed that the necrotic size was at least more than 30 %. Conclusions ： Percutaneous multiple holes decompression combined with autologous BMCs is a new way to treat avascular necrosis of the femoral head. The earlier the stage, the better the result. A randomized prospective study needed to compare with routine core decompression in the future.

关键词： Osteonecrosis femur head Bone marrow

Osteoinductive activity of demineralized bone matrix and deprotenized bone derived from human avascular necrotic femoral head

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Chinese Journal of Traumatology 2009年第6期12卷 379-383页

作者：张波刘明勇赵建华 Department of Orthopaedics Daping Hospital/ Research Institute of Surgery Third military Medical UniversityChongqing400042China

Objective： To observe the osteoinductive activity of demineralized bone matrix （DBM） and deprotenized bone （DPB） made from human avascular necrotic femoral head. Methods： The femoral head was cut into pieces with the size of 3 mm×3 mm×5 mm, which were made into DBM and DPB. These two kinds of biomaterials were cocultured with human bone mesenchymal stem cells （hBMSCs）. Monolayer cells without biomaterials were cultured as control. Proliferative activity ofhBMSCs was evaluated on days 1, 3, 5, 7 and 14. The concentration of alkaline phosphatase （ALP）, osteocalcin （OC）, and Ca^2＋ were detected on days 1, 7, 14 and 21. Results： Cells cultured in DBM showed higher proliferative activity than did in DPB and monolayer cells （F= 39.773, P〈0.01）. DBM and DPB also had osteoinductive activity. The concentrations of ALP （F=93.162, P〈0.01）, OC （F=236.852, P〈0.01）, Ca^2＋（F=80.711, P〈0.01）of DBM group were significantly higher than that of DPB and control groups. Conclusions： In vitro, DBM and DPB made from avascular necrotic femoral head have osteoinductive activity when cocultured with hBMSCs, and the former is stronger than the latter.

关键词： femur head Bone matrix Mesenchymal stem cells Bone substitutes