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Paclitaxel-coated balloons angioplasties for extra-long femoropopliteal artery atherosclerotic lesions(>30 cm):12 months outcomes from a single center

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Journal of Interventional Medicine 2022年第1期5卷 28-31页

作者： Tao Pan Guodong Zhang Zhen Liu Tao Zhang Cheng Li Donghua Ji The Interventional Therapy Department of the First Affiliated Hospital of Dalian Medical University Dalian116011China

Objective:To evaluate the efficacy of paclitaxel-coated balloon(PCB)in the treatment of extra-long femoropopliteal artery atherosclerotic disease(>30 cm).Materials and methods:Forty-nine patients with extra-long femoropopliteal artery atherosclerotic disease were treated with PCB alone in a single center from July 2016 to May *** patency and freedom from clinically driven target lesion revascularization(FF-CDTLR)rates during 12 months were analyzed ***:All patients were followed up for 18.2±7.5 months,and the mean treated lesion length was 34.9±3.7 *** primary patency rates were 87.8%(43/49)and 71.4%(35/49)at 6 and 12 months,*** was 91.8%(45/49)and 77.6%(38/49)at 6 and 12 months,*** mortality or amputation occurred in these patients during the follow-up ***:PCB has favorable clinical efficacy in patients with extra-long femoropopliteal artery atherosclerotic lesions.

关键词： femoropopliteal artery Extra-long lesion Paclitaxel-coated balloon

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Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing femoropopliteal Arterial Endovascular Interventions： Preliminary Results

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Chinese Medical Journal 2015年第12期128卷 1563-1566页

作者： Yue-Xin Chen Wen-Da Wang Xiao-Jun Song Yong-Quan Gu Hong-Yan Tian He-Jie Hu Ji-Chun Zhao Xiao-Qiang Li Chang-Wei Liu Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100068 China Department of Vascular Surgery Peking XuanWu Hospital Beijing 100053 China Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Vascular Surgery Anhui Provincial Hospital Hefei Anhui 230001 China Department of Vascular Surgery West China Hospital Chengdu Sichuan 510100 China Department of Vascular Surgery The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background：Sarpogrelate is a selective 5-hydroxytryptamine （5-HT） receptor subtype 2A antagonist which blocks 5-HT induced platelet aggregation and proliferation of vascular smooth muscle *** compared the efficacy of sarpogrelate-based dual antiplatelet therapies for the prevention of restenosis and target lesion revascularization （TLR） rates comparing with that of clopidogrel after percutaneous endovascular interventions （EVIs） of femoropopliteal （FP） arterial ***：This prospective,multicenter,randomized clinical trial recruited a total of 120 patients with successful EVI of FP lesions at seven centers across China between January 2011 and June *** were randomized to receive either sarpogrelate （100 mg trice daily for 6 months,n =63） or clopidogrel （75 mg once daily for 6 months,n =57）.All patients also received oral aspirin （100 mg once daily for 12 months）.Clinical follow-up was conducted up to 12 months ***：There was no significant difference between the two groups in basic demographic *** restenosis rate was higher in the clopidogrel group （22.80%） than in sarpogrelate group （17.50%）,but there was no significant difference between these two groups （P =0.465）.The TLR rate,ipsilateral amputation rate,mortality in all-cause and bleeding rate were also similar in the two groups （P 〉 0.05）.Conclusions：Aspirin plus sarpogrelate is a comparable antithrombotic regimen to aspirin plus clopidogrel after EVI of FP arterial *** antiplatelet therapies might play an important role in preventing restenosis after successful EVI of FP lesions.

关键词： Clopidogrel femoropopliteal artery Percutaneous Endovascular Interventions Restenosis Sarpogrelate

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