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Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast,cervical,ovarian,and endometrial cancer susceptibilities

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Chronic Diseases and Translational Medicine 2021年第3期7卷 169-181页

作者： Wang Zheng Kai Li Ling Ouyang Hidasa Iko Ahmad Javid Safi Shan Gao Department of Otorhinolaryngology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Surgical Oncology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Obstetrics and Gynecology The Shengjing Hospital of China Medical UniversityShenyangLiaoning 110001China Japan Shouko Co.Ltd Nisikujo 3-5-4 Konohanaku Osakashi Osakafu Japan554-0012Japan Afghanistan Cancer Foundation Kart-e-CharKabulAfghanistan

Background:Recent studies identifying methylenetetrahydrofolate reductase(MTHFR)polymorphisms associated with breast cancer(BC),ovarian cancer(OC),cervical cancer,and endometrial cancer(EC)have reported conflicting results and been *** clarify the correlation betweenMTHFR mutations and these common female malignancies,we conducted a comprehensive meta-analysis incorporating all eligible ***:Relevant reports published before January 20,2020,were retrieved from PubMed,Embase,the Cochrane Library,and the China National Knowledge Infrastructure *** odds ratio and 95% confidence interval summaries for theMTHFR 677C/T and 1298A/C polymorphisms in BC,OC,cervical cancer,and EC were ***:A total of 171 studies comprising 56,675 cancer cases and 67,559 controls were *** results showed a markedly elevated risk of cancer susceptibility related toMTHFR 677C/T based on all genetic ***,we identified a significant correlation between 1298A/C mutation and cancer risk based on overall comparisons among all models,except the heterozygous ***,subgroup analysis by cancer type revealed a significantly increased risk of BC associated with 677C/T in the five models and of cervical cancer associated with 1298A/C in some *** on ethnicity,significant associations were observed between Asian,African,and mixed populations for 677C/T and the Asian population for 1298A/*** regard to the sample type used for analysis,we detected a positive association between using blood as the DNA source and cancer risk for 677C/T in all genetic models and for 1298A/C in some genetic *** stratification of the results revealed that a notably increased risk was associated with the use of polymerase chain reaction-restriction fragment-length polymorphism or TaqMan as the genotyping method,as well as with the use of population-or hospital-based groups as the controls for 677C/T and 1298A/C,***

关键词： Methylenetetrahydrofolate reductase Breast cancer female genital neoplasms Polymorphism Meta-analysis

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