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Medium-chain fatty acids and monoglycerides as feed additives for pig production:towards gut health improvement and feed pathogen mitigation

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Journal of Animal Science and Biotechnology 2020年第3期11卷 611-625页

作者： Joshua A.Jackman RDean Boyd Charles C.Elrod School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Hanor Company FranklinKY 42134USA North Carolina State University RaleighNC 27695USA Natural Biologics Inc. NewfieldNY 14867USA Department of Animal Science Cornell UniversityIthacaNY 14853USA.

Ongoing challenges in the swine industry,such as reduced access to antibiotics and virus outbreaks(e.g.,porcine epidemic diarrhea virus,African swine fever virus),have prompted calls for innovative feed additives to support pig ***-chain fatty acids(MCFAs)and monoglycerides have emerged as a potential option due to key molecular features and versatile functions,including inhibitory activity against viral and bacterial *** this review,we summarize recent studies examining the potential of MCFAs and monoglycerides as feed additives to improve pig gut health and to mitigate feed *** molecular properties and biological functions of MCFAs and monoglycerides are first introduced along with an overview of intervention needs at different stages of pig *** latest progress in testing MCFAs and monoglycerides as feed additives in pig diets is then presented,and their effects on a wide range of production issues,such as growth performance,pathogenic infections,and gut health,are *** utilization of MCFAs and monoglycerides together with other feed additives such as organic acids and probiotics is also described,along with advances in molecular encapsulation and delivery ***,we discuss how MCFAs and monoglycerides demonstrate potential for feed pathogen mitigation to curb disease *** forward,we envision that MCFAs and monoglycerides may become an important class of feed additives in pig production for gut health improvement and feed pathogen mitigation.

关键词： Antibiotics feed pathogen mitigation Growth promotion Gut health Immune enhancement MCFA Medium-chain fatty acids Monoglycerides

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Inhibition of African swine fever virus in liquid and feed by medium-chain fatty acids and glycerol monolaurate

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Journal of Animal Science and Biotechnology 2021年第2期12卷 569-578页

作者： Joshua A.Jackman Astghik Hakobyan Hovakim Zakaryan Charles C.Elrod School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Group of Antiviral Defense Mechanisms Institute of Molecular Biology of NASYerevanArmenia Natural Biologics Inc. NewfieldNY 14867USA. Department of Animal Science Cornell UniversityIthacaNY 14853USA

Background:The ongoing African swine fever virus(ASFv)epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high *** has been recently identified that feed and feed ingredients,along with drinking water,can serve as transmission vehicles and might facilitate transboundary spread of ***,it is important to test the antiviral activity of regulatory compatible,antiviral feed additives that might inhibit ASFv infectivity in *** promising group of feed additive candidates includes medium-chain fatty acids(MCFA)and monoglyceride derivatives,which are known to disrupt the lipid membrane surrounding certain enveloped viruses and ***:The antiviral activities of selected MCFA,namely caprylic,capric,and lauric acids,and a related monoglyceride,glycerol monolaurate(GML),to inhibit ASFv in liquid and feed conditions were investigated and suitable compounds and inclusion rates were identified that might be useful for mitigating ASFv in feed *** assays showed that all tested MCFA and GML inhibit *** was more potent than MCFA because it worked at a lower concentration and inhibited ASFv due to direct virucidal activity along with one or more other antiviral ***-dependent feed experiments further showed that sufficiently high GML doses can significantly reduce ASFv infectivity in feed in a linear manner in periods as short as 30 min,as determined by infectious viral titer ***-linked immunosorbent assay(ELISA)experiments revealed that GML treatment also hinders antibody recognition of the membrane-associated ASFv p72 structural protein,which likely relates to protein conformational changes arising from viral membrane ***:Together,the findings in this study indicate that MCFA and GML inhibit ASFv in liquid conditions and that GML is also able to reduce ASFv infectivity in feed,which may help to curb disease tr

关键词： African swine fever virus Antiviral feed pathogen mitigation MCFA Medium-chain fatty acids Monoglycerides

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