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Trajectory of fecal lactoferrin for predicting prognosis in ulcerative colitis

Precision Clinical Medicine 2023年第3期6卷 172-179页

作者： Rirong Chen Li Li Yizhe Tie Minhu Chen Shenghong Zhang Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000China

Objectives:To investigate the characteristics and prognostic value of fecal lactoferrin trajectories in ulcerative colitis(UC).Methods:This study used data from the UNIFI trial(***,NCT02407236)and included patients who received ustekinumab during induction for trajectory modeling(n=637).Patients who received ustekinumab during maintenance therapy were used for 1-year outcome analyses(n=403).The levels of fecal lactoferrin,fecal calprotectin,and serum C-reactive protein were measured at weeks O,2,4,and *** trajectories of these biomarkers were developed using a latent class growth mixed ***:The trajectories of fecal lactoferrin,fecal calprotectin,and serum C-reactive protein were distinct,but all were associated with prior exposure to anti-tumor necrosis factor agents and ***,the fecal lactoferrin trajectory was the most valuable predictor of endoscopic,clinical,and histological *** to the high/moderate-rapid decrease trajectory group,the moderate-slow decrease,high-slow decrease,and high-stable groups had adjusted odds ratios(95%confidence interval)of o.38(0.18,0.78;P=0.010),0.47(0.23,0.93;P=0.032),and 0.33(0.17,0.63;P=0.001),respectively,of 1-year endoscopic *** with high/moderate-rapid decrease trajectories also had the highest likelihood of achieving clinical and histological ***,we developed a patient-stratification scheme based on fecal lactoferrin trajectories and *** with good,moderate,and poor prognoses in the scheme had a distinct probability of achieving 1-year endoscopic remission(52.7%,30.9%,and 12.8%,respectively).Conclusions:The trajectory of fecal lactoferrin is a valuable prognostic factor for 1-year remission in UC.

关键词： ulcerative colitis fecal lactoferrin trajectory

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fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease

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World Journal of Gastrointestinal Pathophysiology 2019年第5期10卷 54-63页

作者： Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino IBD Center-Division of Gastroenterology Virginia Tech Carilion School of MedicineRoanokeVA 24016United States Department of Radiology Virginia Tech Carilion School of MedicineRoanokeVA 24016United States Department of Basic Science Education Virginia Tech Carilion School of Medicine and Dominion Pathology Associates RoanokeVA 24016United States K.R.Love Quantitative Consulting and Collaboration AthensGA 30605United States Research and Development TECHLAB IncBlacksburgVA 24060United States Department of Clinical and Experimental Medical Sciences University of Udine School of MedicineUdine 33100Italy

BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively *** To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and *** Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of *** location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were *** In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,Psmall bowel)and the number of inflamed colon *** FL and CRP separated disease severity categories with FL showing lower discriminating *** showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL *** can accurately and timely characterize intestinal inflammation in IBD.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis fecal lactoferrin C-reactive protein White blood cell count Mucosal inflammation

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