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A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis

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Asian Pacific Journal of Tropical Medicine 2020年第7期13卷 301-307页

作者： Tsung-Hang Kuo Chia-Chang Chuang Chin-Chung Tseng Ming-Yuan Hong Sheng-Hsiang Lin Institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainan 70403 Department of emergency National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 70403 Department of Internal Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 70403 Biostatistics Consulting Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 70403 Department of Public Health College of MedicineNational Cheng Kung UniversityTainan 70403

Objective:To identify the febrile characteristics and clinical presentations associated with fatality in hospitalized adult patients with dengue virus(DENV)***:A total of 289 adult hospitalized patients with laboratoryconfirmed DENV infections were examined,of which 22 were fatal and 267 were non-fatal.A comparison of the clinical and laboratory characteristics was retrospectively conducted of the deceased and surviving *** logistic regression and receiver operating characteristic curve analysis were performed to identify predictors of ***:Fatal patients exhibited significantly more comorbidities,particularly renal and cardiac comorbidities,and they were,in general,older than control individuals(Pfebrile duration of less than four days before arriving in the Emergency Department(OR=5.34;95%CI:1.39–20.6),episode of hypotension in the Emergency Department(OR=6.95;95%CI:2.40–20.1),and comorbidity with congestive heart failure(OR=11.26;95%CI:2.31–54.79)were all significantly associated with inpatient fatality due to DENV *** ROC curve analysis indicated that the final prognostic model yielded an area under the curve of 0.87(95%CI:0.79–0.97)for ***:The aforementioned clinical findings may help clinicians predict fatality among adult inpatients with DENV infection.

关键词： Dengue Hospitalized patient Adult Fatality febrile duration Hypotension

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