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Effect of zinc protoporphyrin on carbon monoxide/heme oxygenase-1 system in rats subjected to recurrent febrile convulsion

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Neural Regeneration Research 2007年第8期2卷 466-470页

作者： Xianhe Wang Jingyue Gu Xianghong Wu Qingyun Meng Mei Mei Department of Pediatrics First Hospital Affiliated to Jiamusi University Jiamusi 154002 Heilongjiang Province China

BACKGROUND： Studies on febrile convulsion （FC）-caused brain injury are disputed in many aspects. How FC cause nervous system injury in the developmental period and what are the characteristics of these pathological injury are unknown. The current studies have demonstrated that berne oxygenase-1 （HO-1） exerts effects on brain injury mainly by catalyzing hemoglobin to produce degradation products, and HO-1 not only has neuroprotective effects, but also has neurotoxic effects during the FC-caused brain injury. Study on the effect of zinc protoporphyrin （ZnPP） on brain injury is still in the stage of animal experiment. OBJECTIVE： To observe the effects of ZnPP on carbon monoxide （CO）/HO-1 system of rats subjected to FC, and to analyze the action pathway of ZnPP in brain protective effect. DESIGN： A randomized controlled animal experiment. SETTING： Department of Pediatrics, First Hospital Affiliated to Jiamusi University. MATERIALS： Sixty-five Wistar rats, of either gender, were involved in this study. They were randomized into normal control group（ n =14, 37℃ water bath） and febrile treatment group （n =51, 44.5℃ hot water bath）. febrile treatment group was sub-divided into febrile non-convulsion group （FNC group, n =16） and FC group （n =35）. FC group was further sub-divided into simple convulsion group （n =20） and ZnPP treatment group （n =15）. HO-1 mRNA in situ hybridization kit was provided by Boster Bioengineering Co.,Ltd. ZnPP（dark brown powder） was the product of Jingmei Bioengineering Company. METHODS： This study was carried out in the postgraduate laboratory of Jiamusi University between January 2004 and January 2007. Rats in the febrile treatment group were placed in the 44.5℃ hot water bath box. If rats did not convulse in the water within 5 minutes, they were taken out, namely FNC group （n = 16）, and those, which were convulsed within 5 minutes, were taken out immediately when they presented such a phenomenon, namely FC group （n =35）. convulsion induction was

关键词： zinc protoporphyrin febrile convulsion hemeoxygenase carbon monoxide brain

Immune Function of T-lymphocyte and Erythocyte in Children with febrile convulsion

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中国当代儿科杂志 2001年第4期 469-473页

作者： ZOU Zheng, CHEN Sui, XU Shu-Juan MEI Kui-Min, CHEN Zhi-Jun, FU Ying-Yuan, ZENG Xiao-Ping, YANG HuiDepartment Internal Medicine, Jiangxi Children’s Hospital, Nanchang 330006, China

Objective To study the immune function of T-lymphocyte and erythrocyte in the peripheral blood of children with febrile convulsion. Methods Eighty-two children with typical febrile convulsion, 40 children with acute upper respiratory tract infection (URI) and 40 normal children were enrolled. The proliferation reaction of T-lymphocyte to PHA, distribution of T-lymphocyte phenotype subsets, expression of activation markers CD25 (IL-2R) and HLA-DR, and level of γ-interferon induced by PHA were assayed. Erythrocyte immune function was simultaneously measured by rosette formation rates of RBC-C3bR and RBC-IC. Results The counts per minute (CPM) and stimulation index (SI), the measurements expressing T-lymphocyte proliferation assay in simple febrile convulsion (SFC) children, were 5 609.4± 3 587.4 and 20.5± 15.6, and 2 817.3± 2 422.8 and 11.0± 8.4 in complex febrile convulsion (CFC) children. They were significantly lower than those in the normal controls ( 20 305.9± 12 810.3 and 69.2± 45.2) and in the URI group ( 9 785.2± 7 509.8 and 44.5± 39.8) (P< 0.05). The CD3, CD4 and CD4/CD8 ratio in the SFC children were ( 40.0± 8.2)%, ( 26.1± 9.0)% and 1.1± 0.4 and ( 932.8± 6.9)%, ( 17.8± 4.9)% and 0.8± 0.1 in the CFC children. They were all significantly lower than those in the normal controls [( 64.1± 6.7)%, ( 47.7± 5.5)% and 1.9± 0.8] and in the URI group [( 63.0± 9.3), ( 42.4± 8.2)% and 1.6± 0.4] (P< 0.01). The expression rates of CD25 (IL-2R) and HLA-DR antigen in the spontaneous condition in the SFC children were ( 8.9± 3.6)% and ( 16.2± 5.6)% and ( 6.3± 1.9)% and ( 12.4± 3.4)% in the CFS children. They were lower than those in the normal controls [( 12.8± 2.5)% and ( 20.2± 5.2)%]and in the URI group [( 15.0± 3.0)% and ( 20.5± 2.8)%] (P< 0.01) and there were also differences in the SFC children and in the CFS children (P< 0.05). After PHA induction, the expression rates of CD25 (IL-2R) and HLA-DR antigen in the SFC children were ( 57.0± 5.1) and ( 57.8± 6.0) and ( 53.0± 1

关键词： febrile convulsion T-lymphocyte, RBC Immune function Child

NSE与视频脑电图在儿童热性惊厥的相关性研究(英文)

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中国医学工程 2002年第6期10卷 29-30页

作者：刘秀琴于树红孙若鹏青岛市立医院儿科青岛266011 山东齐鲁医院儿科

Objective:To evaluate the diagnostic value of serum neuron specific enolase and Video EEG in febrile convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day after seizure in 40 children with simple febrile convulsion and 18 with complex febrile convulsion. Video EEG was performed at 1st, 7th and 30th day in all the patients. Results: There were significant differences between NSE levels at 24th hour and on 7th day after convulsion (P＜0.01). NSE concentrations in patients with SFC and CFC were also different (P ＜ 0.01). The more slowly NSE restored, the higher the abnormal ratio of EGG was . Conclusion: NSE increased in patients within 24hours after seizure, especially in CFC patients. The abnormal ratio of VideoEEG was related to the change of NSE concentration.

关键词： Serum NSE Video EEC febrile convulsion

Na^＋/Ca^2＋ Exchanger 3 is Downregulated in the Hippocampus and Cerebrocortex of Rats with Hyperthermia-induced convulsion

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Chinese Medical Journal 2015年第22期128卷 3083-3087页

作者： Dan Sun Jun-Hua Xiao Yan Bai Mo-Si Chen Jia-Sheng Hu Ge-Fei Wu Bing Mao Shu-Hua Wu Yan Hu Department of Pediatric Neurology Wuhan Children's Hospital Wuhan Hubei 430016 China Department of Pharmacology Basic Medical College Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Background： Na^＋/Ca^2＋ exchanger （NCX） plays a crucial role in pentylenetetrazol-induced convulsion. However, it is unclear whether NCX is critically involved in hyperthermia-induced convulsion. In this study, we examined the potential changes in NCX3 in the hippocampus and cerebrocortex of rats with hyperthermia-induced convulsion. Methods： Twenty-one Sprague Dawley rats were randomly assigned to control group, convulsion-prone group and convulsion-resistant group （n = 7 in each group）. Whole-cell patch-clamp method was used to record NCX currents. Both the Western blotting analysis and immunofluorescence labeling techniques were used to examine the expression of NCX3. Results： NCX currents were decreased in rats after febrile convulsion. Compared to the control group, NCX3 expression was decreased by about 40% and 50% in the hippocampus and cerebrocortex of convulsion-prone rats, respectively. Furthermore, the extent of reduction in NCX3 expression seemed to correlate with the number of seizures. Conclusions： There is a significant reduction in NCX3 expression in rats with febrile convulsions. Our findings also indicate a potential link between NCX3 expression, febrile convulsion in early childhood, and adult onset of epilepsy.

关键词： Cerebrocortex febrile convulsion Hippocampus Hyperthermia Na^+/Ca^2+ Exchanger 3

Clinical Analysis of the Relationship between convulsion and Blood Electrolyte in Children

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Journal of Behavioral and Brain Science 2022年第11期12卷 552-568页

作者： Wanqi Li Peiqing Li Xiaowei Fan Guangming Liu Qiang Wang Department of Pediatric Emergency Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Objective: febrile convulsion in children is age-dependent and genetic predisposition. However, mild electrolyte disturbances are not uncommon in such children. This study was to investigate the effect of electrolyte disturbance on febrile convulsion and to screen for febrile convulsion-related genes. Methods: This retrospective cohort study included children who admitted to the Pediatric Emergency Department of Guangzhou Women and Children’s Medical Center due to fever and febrile convulsion between May to December 2020. Clinical manifestations and serum electrolyte levels were recorded and analyzed by binary logistic regression on risk factors of convulsion, and children with family histories were screened for febrile convulsion-related genes. Results: This study included 322 children with fever: 161 in the febrile convulsion group (FC Group) including 71 in the single convulsion group (SC Group) and 90 in the multiple convulsion group (MC Group), and the control group consisted of 161 children with fever without convulsion and nervous system disease. Serum sodium, potassium and calcium in FC Group were lower than those in the control group (p Conclusion: Hyponatremia may be a relative risk factor in febrile convulsion, and for children with a family history of febrile convulsion and serum sodium lower than 133 mmol/L, related gene analysis can be performed.

关键词： febrile convulsion Electrolyte Recurrence of convulsion Hyponatremia Family History Gene