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fe-zn alloy, a new biodegradable material capable of reducing RoS and inhibiting oxidative stress

Regenerative Biomaterials 2024年第2期3卷 114-122页

作者： Shuaikang Yang Weiqiang Wang Yanan Xu Yonghui Yuan Shengzhi Hao School of Materials Science and Engineering Dalian University of TechnologyDalian 116024PR China Clinical Research Center for Malignant Tumor of Liaoning Province Cancer Hospital of Dalian University of TechnologyShenyang 110042PR China

fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable ***,research on fe-based materials mainly focuses on regulating the degradation ***,excessive release of fe ions during material degrada-tion will induce the generation of reactive oxygen species(ROS),leading to oxidative stress and ***,the con-trol of RoS release and the improvement of biocompatibility for fe-based materials are very *** this study,new fe-zn alloys were prepared by electrodeposition with the intention of using zn as an antioxidant to reduce oxidative damage during alloy ***,the impact of three potential degra-dation ions(fe^(2+),fe^(3+),zn^(2+))from the fe-zn alloy on human endothelial cell(EC)activity and migration ability was ***,cell adhesion,cell activity,ROs production and DNA damage were assessed at various locations surrounding the ***,the influence of different concentrations of zn^(2+) in the medium on cell viability and ROS production was *** levels of ROS exhibited evident toxic effects on ECs and promoted DNA *** an antioxidant,zn?+effectively reduced ROS production around fe and improved the cell viability on its surface at a concentration of 0.04 mmol/*** findings demonstrate that fe-zn alloy can attenuate the ROS generated from fe degradation therebyenhancingcytocompatibility.

关键词： biodegradable iron fe-zn alloys reactive oxygen species oxidative stress cytocompatibility

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