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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the fc fragment of the igg-binding protein as a serum biomarker and implicates potential therapeutic targets

引用

Frontiers of Medicine 2022年第3期16卷 378-388页

作者： Jinrong Liu Rongfang Shen Lin Feng Shujun Cheng Jun Chen Ting Xiao Shunying Zhao Department of Respiratory Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Engineering Research Center of Pediatric Surgery Engineering and Transformation CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

Macrolide and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniae(MP)pneumonia(MPP).MP clearance is difficult to achieve through antibiotic treatment in sensitive patients with severe MPP(SMPP).SMPP in children might progress to airway remodeling and even bronchiolitis/bronchitis ***,identifying serum biomarkers that indicate MPP progression and exploring new targeted drugs for SMPP treatment require *** this study,serum samples were collected from patients with general MPP(GMPP)and SMPP to conduct proteomics *** fc fragment of the igg-binding protein(fcGBP)was identified as the most promising indicator of *** enrichment analysis indicated uncontrolled inflammation in *** results proved that the fcGBP level in patients with SMPP was substantially higher than that in patients with ***,the fcGBP levels showed a decreasing trend in patients with GMPP but the opposite trend in patients with SMPP during disease *** map analyses identified 25 possible targeted drugs for SMPP *** them,a mechanistic target of rapamycin kinase(mTOR)inhibitor,which is a macrolide compound and a cell proliferation inhibitor,was the most promising candidate for targeting *** our knowledge,this study was the first proteomics-based characterization of patients with SMPP and GMPP.

关键词： severe Mycoplasma pneumoniae pneumonia children proteomics fc fragment of the igg-binding protein mechanistic target of rapamycin kinase inhibitor

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