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Treatment of fatal hepatitis in the intermediate and advanced stages by artificial liver support system with continuous hemodialysis and filtration

Treatment of fatal hepatitis in the intermediate and advance...

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第一届全国人工肝及血液净化学术年会暨全国人工肝及血液净化攻关协作组成立大会

作者： He Jinqiu Che DaPing Liu Yan Chen Jiangqing Zhang QiYong Den jianTing Lu DingYing. Nanchang Ninth People’s Hospital,Jiangxi,Nanchang 330032,China

Objective To find the clinical effects of artificial liver support system (ALSS) with continuous hemodialysis and filtration (CHDF) on the treatment of fatal hcpatitis in the intermediate and advanced stages and observe if hepatic encephalopathy,hepatorenal syndrome and function of cleating the cellular factor have been *** To treat 33 cases of fatal hepatitis in the intermediate and advanced stages 96 times,and 2.9 times averagely in the treatment group by the way of ALSS and CHDF,and compare the clinical manifestation,degree of hepatic encephalopath,restoration of renal function and levers of TBIL、NH、 PT、PTa,、BUN、Cr、electrolytic tension,TNF-α、IL-6 and LSP prior to and subsequent to the *** contrast group consists of 36 cases of similar patients who were abmitted to the hospital during the same period of *** 63.64% at survival rate and 27.27% at case fatality rate in the treatment group,but 36.11% and 52.78% (P<0.01) respectively in the contrast group:81.08% at revival rate for hepatic encephalopathy.9 out of 13 cases of hepatorenal syndrome have restored the renal function,but 2 out of 14 cases of hepatorenal syndrome have restored renal function in the contrast group;TBIL,NH,BUN and Cr have been obviously reduced,the electrolyte disorder has been rectified,and TNF-α.*** have been redrced respectively to (53.60±14.27)pg/ml (P<0.01),(39.48±13.15)pg/ml (P<0.01)and (1.33±0.41)Eu/ml (P<0.05) from (18.14±22.65) pg/ml,(66.67±18.37) pg/ml,(3.81±0.62) Eu/ml afterthe *** 21 patients who have received the treatment of plasma exchange with CHDF (64 times),there are 5 cases (12.5%) of plasma allergy,and among 9 patients who have received the treatment of plasma absorption with CHDF and blood perfusion with (25 times),There are 2 cases of thrombocytopenia 5 *** the operation,there are 6 cases of capillary hemorrhage (9 times) in the region of *** 1 case of rupture of right kidney in the therapeutic process o

关键词： fatal hepatitis in the intermediate and advanced stages Artificial liver support system Continuous hemodialysis and filtration Hepatic encephalopathy Hepatorenal syndrome Cellular factor.

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