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Is fat-free mass-based gentamicin dosing regimen preferable than whole-body weight in neonates?

Pediatric Investigation 2023年第2期7卷 86-94页

作者： Kannan Sridharan Muna Al Jufairi Eman Al Ansari Lulwa Alsadah Howra Wasel Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Neonatal Intensive Care Unit Salmaniya Medical ComplexMinistry of HealthManamaKingdom of Bahrain Department of Pediatrics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain College of Medicine and Medical Sciences Arabian Gulf UniversityManamaKingdom of Bahrain

Importance:Body fluid dynamics and renal maturation status vary during the neonatal *** hypothesized that differences in peak and trough gentamicin concentrations could be ***:To predict the peak and trough gentamicin concentrations in critically ill neonates and to predict the changes in the predicted peak plasma concentrations of gentamicin following fat-free mass ***:Critically ill neonates that received gentamicin and have gentamicin concentration measured were *** mass was estimated using skinfold *** in the peak plasma concentrations(Cmax)using whole-body weight(estimated using the current dosing regimen)and predicted concentrations following the fat-free mass-based dosing were the outcome ***:Eighty-nine critically ill neonates were ***-therapeutic Cmax was estimated using the current dosing regimen in 32.6%,and 22.5%neonates following the first and second doses of *** neonates had significantly higher fat mass compared to term *** except one had Cmax above 12μg/ml after the first dose and all had after the second gentamicin dose following the predicted fat-free massbased gentamicin *** recommended doses are as follows:extreme preterm:7.95 mg/kg every 48 h;very preterm:7.30 mg/kg every 36-48 h;late preterm:5.90 mg/kg every 36-48 h;and term neonates at 5.10 mg/kg every 24 ***:fat-free mass dosing may be considered for obtaining optimal therapeutic effects in the neonatal population.

关键词： Aminoglycosides Body weight fat fat-free mass Gentamicin

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Association between IGF-2 gene and fat-free mass in response to resistance training

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Health 2013年第6期5卷 1003-1009页

作者： Andrea Carmem Guimaraes Rinaldo Wellerson Pereira Ricardo Moreno Lima Michel Santos Silva Victor Machado dos Reis Nuno Domingos Garrido Romulo Maia Ricardo Jacode Oliveira College of Physical Education Catholic University of BrasiliaBrasiliaBrazil College of Physical Education University of BrasiliaBrasiliaBrazil Health Sciences Postgraduate Program University of BrasiliaBrasiliaBrazil Department of Sports Sciences Exercise and HealthUniversity of Tras-os-Montes and Alto DouroVila RealPortugal Research Center for Sports Health&Human DevelopmentCIDESDVila RealPortugal

BACKGROUND: It is well established that the human aging process is associated with a significant decline in neuromuscular function and performance. Twin studies demonstrate that genetic factors partially explain the inter-individual variation of fat-free mass (FFM) and muscle strength. PURPOSE: To examine the association between the polymorphism of the gene IGF-2 with phenotypes strength and muscle mass of elderly women pre and post resistance training. METHODS: 76 elderly women participated in this analysis. These volunteers, who should be sedentary for at least 6 months before the study, were assigned four groups in relation to allele GAGG, AA, GAAA and GG. The first analysis compared 60 elderly women with GG and GA allele (GAGG) versus 16 elderly women with AA allele. The second analysis compared 54 elderly women with GA and AA (GAAA) versus 22 elderly women GG allele. The Body mass index, fat free mass, fat mass and Isokinetic Muscle Peak Torque were measured. All volunteers were participating in the Resistance Training program. The DNA was extracted from peripheral venous blood leukocytes using a salting out protocol. The primer for IGF-II gene exon 9 was 5’-GTCCCTGAACCAGCAAAGAG-3’ 0.5 μM (0.625 μl) Primer R-5’-TGATGGAAAAGGGAGTGAGG-3’ 0.5 μM (0.625 μl), Taq DNA Polimerase enzime 0.5 U (0.1 μl), água milli-Q (3.8 μl) 5 hg de DNA (3 μl). PCR amplification was performed in a programmable thermal cycler GeneAmp? PCR System 9700. RESULTS: The results of the first analysis GAGG × AA versus the group AA showed the relative increase in knee extensor peak torque relative and also in the fat-free mass and showed a decrease in the fat mass percentage in the GAGG group. The second analysis considered the group GAAA versus group GG showed decreases in the fat-free mass percentage in the GAAA group, also showed the relative increase in the fat-free mass in the GG group and decrease in the fat mass percentage in the GG group. CONCLUSIONS: The results of this study show that 2

关键词： fat-free mass fat mass Resistance Training Muscle Strength IGF-2 Polymorphism Elderly

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