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Lysine 2-hydroxyisobutyrylation levels determined adipogenesis and fat accumulation in adipose tissue in pigs

Journal of Animal Science and Biotechnology 2024年第5期15卷 2093-2105页

作者： Enfa Yan Mingyang Tan Ning Jiao Linjuan He Boyang Wan Xin Zhang Jingdong Yin State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal Science and Veterinary Medicine Shandong Agricultural UniversityTaian 271018Shandong ProvinceChina Molecular Design Breeding Frontier Science Center of the Ministry of Education(MOE) Beijing 100193China

Background Excessive backfat deposition lowering carcass grade is a major concern in the pig industry,especially in most breeds of obese type *** mechanisms involved in adipogenesis and fat accumulation in pigs remain *** 2-hydroxyisobutyrylation(Khib),is a novel protein post-translational modification(PTM),which play an important role in transcription,energy metabolism and metastasis of cancer cells,but its role in adipogenesis and fat accumulation has not been *** In this study,we first analyzed the modification levels of acetylation(Kac),Khib,crotonylation(Kcr)and succinylation(Ksu)of fibro-adipogenic progenitors(FAPs),myogenic precursors(Myo)and mesenchymal stem cells(MSCs)with varied differentiation potential,and found that only Khib modification in FAPs was significantly higher than that in ***,in parallel with its regulatory enzymes lysine acetyltransferase 5(KAT5)and histone deacetylase 2(HDAC2)protein levels,the Khib levels increased quadratically(Pfat accumulation by comparing Khib levels in FAPs and backfat tissues both derived from obese-type pigs(Laiwu pigs)and lean-type pigs(Duroc pigs),***,the expression patterns of KAT5 and HDAC2 matched well to the degree of backfat accumulation in obese-and lean-type *** From the perspective of protein translational modification,we are the first to reveal the role of Khib in adipogenesis and fat deposition in pigs,and provided new clues for the improvement of fat accumulation and distribution as expected via genetic selection and nutritional strategy in obese-type pigs.

关键词： Adipogenesis Backfat fat accumulation 2-Hydroxyisobutyrylation Intramuscular fat content Pigs

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Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis

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Chinese Journal of Natural Medicines 2019年第12期17卷 892-899页

作者： LING Yi TENG Lin-Lin HUA Juan LI De-Sen LUO Shi-Hong LIU Yan-Chun LIU Yan LI Sheng-Hong State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Obesity that is highly associated with numerous metabolic diseases has become a global health issue *** sesterterpenoids are an important group of natural products with great potential;thus,their bioactivities deserve extensive ***-seq analysis indicated that leucosceptroid B,a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum,significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis ***,leucosceptroid B was found to reduce fat storage,and downregulate the expression of two stearoyl-CoA desaturase(SCD)genes fat-6 and fat-7,and a fatty acid elongase gene elo-2 in wild-type *** addition,leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6;fat-7 double *** findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6,fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty *** findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.

关键词： Sesterterpenoid Leucosceptroid B Leucosceptrum canum Caenorhabditis elegans fat accumulation fatty acid biosynthesis Antilipemic agent

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Dietary Supplementation with Sea Cucumber Saponins and Exercise Can Significantly Suppress Adipose accumulation in Mice Fed with High-fat Diet

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Journal of Ocean University of China 2021年第3期20卷 629-640页

作者： LI Rong MENG Jing SHI Haohao WANG Chengcheng LI Zhaojie XUE Changhu WANG Yuming ZHANG Tiantian College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Jining Center for Food and Drug Control Jining 272025China

Dietary supplementation with sea cucumber saponins(SCS)and exercise have been confirmed to be effective in pre-venting the development of obesity and its related ***,the combined effectiveness of these interventions has not been ***,we studied whether the beneficial influences of exercise could be further enhanced by dietary supplementation with SCS in high-fat diet-fed KM(Kunming)*** were randomly divided into four groups,including the high-fat diet group(HF),the SCS group(HF-S),the exercise group(HF-E),and the combination of dietary SCS and exercise group(HF-S+E).There were eight mice in every *** results demonstrated that the combination of dietary SCS and exercise could synergistically reduce fat *** particular,white adipose tissue decreased by 63%in the HF-S+E group compared with that in the HF *** supplementation with exercise also improved peripheral markers,such as serum parameters and hepatic TG *** mechani-cal testing indicated that the combined effects of dietary SCS and exercise on inhibiting fat accumulation might be attributed to the inhibition of lipid synthesis in the liver and the activation of lipolysis in white adipose tissue to increase energy consumption.

关键词： exercise sea cucumber saponins fat accumulation lipogenesis lipolysis

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