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Tunable inhibition ofβ-amyloid peptides by fast green molecules

Chinese Physics B 2021年第8期30卷 543-550页

作者： Tiantian Yang Tianxiang Yu Wenhui Zhao Dongdong Lin Department of Microelectronic Science and Engineering Department of PhysicsSchool of Physical Science and TechnologyNingbo UniversityNingbo 315211China Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences Ningbo UniversityNingbo 315211China

The aggregation ofβ-amyloid(Aβ)protein into toxic intermediates and mature fibrils is considered to be one of the main causes of Alzheimer's disease(AD).Small molecules as one of blockers are expected to be the potential drug treatment for the ***,the nucleation process in molecular assembly is less informative in the *** this work,the formation of Aβ(16-22)peptides was investigated with the presence of small molecule of fast green(FG)at the initial aggregation *** results exhibited the tunable inhibitory ability of FG molecules on Aβ(16-22)*** force microscopy(AFM)demonstrated that the inhibitory effect would be dependent on the dose of FG molecules,which could delay the lag time(nucleation)and form single layer *** measurements further showed that theβ-sheet secondary structure of Aβ(16-22)reduced dramatically after the presence of FG ***,non-β-sheet nanosheets were formed when the FG/Aβ(16-22)ratio reached 1:*** addition,the cytotoxicity of aggregates reduced greatly with the presence of FG molecules compared with the Aβ(16-22)***,this study provided a method for suppressing the toxic amyloid aggregates by FG molecules efficiently,and also showed a strategy for fabrication of two-dimensional materials by small molecules.

关键词： amyloid fast green aggregation Alzheimer's disease

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The kinetics study of the reduction of fast green dye with cetylpyridinum chloride as cationic surfactant

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Frontiers of Chemistry in China 2011年第2期6卷 105-112页

作者： Muhammad SULTAN Hajira TAHIR Khalid AHMED Qazi JAHANZEB Department of Chemistry University of KarachiKarachi 75270Pakistan

The kinetics of the reaction of fast green dye(FG)with cetylpyridinum chloride was studied in alkaline medium by UV-Visible *** of fast green dye was carried out by varying the fast green dye concentration,cetylpyridinum chloride concentration and concentration of sodium *** the present study the reduction of dye was carried out in order to reduce the color *** interaction of dye was carried out with reducing analyte(cetylpyridinum chloride).The rate of the reaction was determined by varying the above parameters at different *** was observed that the reduction followed pseudo first-order kinetics with respect to dye,surfactant,OH–ion concentration according to the following reaction *** like entropy of activation(ΔS)and free energy of activation(ΔG)showed the extremely solvated states of transient complex which was less disorderly arranged than the oxidized form of dye,whereas Ea values reflects a high amount of energy required for the reduction of dye with cetylpyridinum chloride.

关键词： fast green cetylpyridinum chloride OH-ions decoloration cationic surfactant

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A New Indicator Reaction and Its Application-Catalytic Determination of Ultratrace Amounts of Rhodium with Linear Sweep Voltammetry

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Chemical Research in Chinese Universities 1993年第1期9卷 85-90页

作者： WANG Li-sheng and JIANG Zhi-liang (Department of Chemistry, Guangxi Normal University, Guilin, 541004)

Introduction Sensitive linear sweep voltammetry to have been applied to the catalytic kinetic analysis may be helpful for the application of some organic reagents to the analysis of inorganic ones by voltammetry, The catalytic reaction-linear sweep voltammetric method for the determination of noble metals, such as Ag, Os, Ru and Ir has been developed, but no report about the method for the determination of rhodium has been published so far.

关键词： Linear sweep voltammetry Catalyti method Rhodium fast green

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