检索结果-南通市图书馆

cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer

引用

cancer Biology & Medicine 2023年第2期20卷 147-154页

作者： Jiaming Liu Lu Yao Jie Sun Li Hu Jiuan Chen Juan Zhang Ye Xu Yuntao Xie Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Familial&Hereditary Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:The spectrum and risk of cancer in relatives of BRCA1/2 pathogenic variant carriers in the Chinese population have not been ***:A family history of cancer in 9903 unselected breast cancer patients was retrospectively ***1/2 status was determined for all patients and relative risks(RRs)were calculated to evaluate cancer risk in relatives of the ***:The incidences of breast cancer in female relatives of BRCA1 carriers,BRCA2 carriers,and non-carriers were 33.0%,32.2%,and 7.7%,*** corresponding incidences of ovarian cancer were 11.5%,2.4%,and 0.5%,*** incidences of pancreatic cancer in male relatives of BRCA1 carriers,BRCA2 carriers,and non-carriers were 1.4%,2.7%,and 0.6%,*** corresponding incidences of prostate cancer were 1.0%,2.1%,and 0.4%,*** risks of breast and ovarian cancers in female relatives of BRCA1 and BRCA2 carriers were significantly higher than female relatives of non-carriers(BRCA1:RR=4.29,Pcancers were noted in male relatives of BRCA2 carriers than non-carriers(RR=4.34,P=0.001 and RR=4.86,P=0.001,respectively).Conclusions:Female relatives of BRCA1 and BRCA2 carriers are at increased risk for breast and ovarian cancers,and male relatives of BRCA2 carriers are at increased risk for pancreatic and prostate cancers.

关键词： BRCA1 variant BRCA2 variant cancer risk in relatives Chinese breast cancer patients family history of cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stomach cancer screening and preventive behaviors in relatives of gastric cancer patients

引用

World Journal of Gastroenterology 2011年第30期17卷 3518-3525页

作者： Jung Min Kang Dong Wook Shin Young Min Kwon Sang Min Park Min Sun Park Jin Ho Park Ki Young Son Be Long Cho Department of family Medicine Seoul National University Hospital101 DaehangnoJongno-Gu110-744 SeoulSouth Korea

AIM:To investigate gastric cancer screening and preventive behaviors among the relatives of patients with gastric cancer[i.e.,gastric cancer relatives(GCRs)].METHODS:We examined the Korean National Health and Nutrition Examination Survey 2005(KNHANESⅢ) database and compared the gastric cancer screening and preventive behaviors of GCRs(n=261)with those of non-GCRs(n=454)and controls without a family history of cancer(n=2842).RESULTS:The GCRs were more likely to undergo gastric cancer screening compared with the control group(39.2%vs 32.3%,adjusted odds ratio:1.43,CI:1.05-1.95),although the absolute screening rate was *** patterns and smoking rates did not differ significantly between the groups,and a high proportion of GCRs reported inappropriate dietary habits(i.e.,approximately 95%consumed excessive sodium,30% were deficient in vitamin C,and 85%were deficient in dietary fiber).CONCLUSION:The gastric cancer screening and preventive behaviors of GCRs have yet to be *** increase awareness among GCRs,systematic family education programs should be implemented.

关键词： family history of cancer cancer relatives Gastric cancer screening Preventive behaviors cancerprevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：