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Seroepidemiology of hepatitis B virus infection and impact of vaccination

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World Journal of Gastroenterology 2015年第25期21卷 7842-7850页

作者： Peng Huang Li-Guo Zhu Ye-Fei Zhu Ming Yue Jing Su Feng-Cai Zhu Hai-Tao Yang Yun Zhang Hong-Bing Shen Rong-Bin Yu Xiang-Jun Zhai Zhi-Hang Peng Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Jiangsu Provincial Centre for Disease Control and Prevention Department of Infectious Disease The First Affiliated Hospital of Nanjing Medical University Department of Epidemiology Medical Institute of Nanjing Army

AIM: To investigate hepatitis B virus(HBV) prevalence in the general population in ***: A total of 148931 individuals were investigated by multistage random sampling in Eastern China. Data were collected on demographics and hepatitis B vaccination history, and serum was tested for hepatitis B surface antigen(HBs Ag) by ELISA. RESULTS: A total of 11469 participants(7.70%, 95%CI: 7.57%-7.84%) were positive for HBs Ag. HBs Ag prevalence was 0.77% among children familial history of HBV among both children and adult groups. Meanwhile, HBs Ag risk in adults was associated with invasive testing and sharing needles. The HBV immunization rate among participants aged < 20 years was 93.30%(95%CI: 93.01%-93.58%). Significant difference in HBs Ag prevalence appeared between vaccinated and unvaccinated participants(3.59% vs 10.22%). CONCLUSION: Although the national goal of HBs Ag prevalence < 1% among children < 5 years old has been reached, immunization programs should be maintained to prevent resurgence.

关键词： Epidemiological study familial history Hepatitis B surface antigen Immunization Generalpopulation

Neurological Disorder

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China Medical Abstracts(Internal Medicine) 2012年第3期29卷 187-191页

ADDISON'S DISEASE OF AUTOSOMAL DOMINANT INHERITANCE——A REPORT OF 11 CASES IN ONE FAMILY

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Chinese Science Bulletin 1985年第7期30卷 981-984页

作者：刘传第曹俊卿宋若华张汝谦杨贵林刘蔚杨文英张青刘桂荣李鹤玲董士勤 Department of Medicine Affiliated Xuanwu Hospital Beijing Second Medical College

Congenital Addison’s disease due to autosomal dominant inheritance has not been reported in domestic and foreign literature yet. In this note, 11 cases of congenital Addison’s diseases among 66 persons in one family... 详细信息

关键词： inheritance autosomal congenital etiology bilateral remarkable autoimmune adrenal urine familial

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METABOLISM

China Medical Abstracts(Internal Medicine) 2002年第2期19卷 74-75页

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Pancreas

China Medical Abstracts(Internal Medicine) 2005年第3期22卷 170-172页

*** and tumor of pancreas2005385 Clinical epidemiological research on pan-creatic cancer:an analysis of 1027 ***(周国中),et *** Digestol,ChanghaiHosp,2nd Milit Med Univ Chin PLA,Shanghai *** Chin J Digestol 2005;13(1)... 详细信息

关键词： pancreas pathogenic amylase inhibited Pancreas proliferating familial severity pathogenesis assessed

Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 615-622页

作者： Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi Department of Pathology Microbiology and Immunology Vanderbilt University Medical Center Department of Surgery Surgical Oncology Vanderbilt University Medical Center Department of Surgery Surgical Oncology University of Miami Hospital

AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC.

关键词： β-catenin familial adenomatous polyposis Pancreatic neuroendocrine neoplasm Adenomatous polyposis coli E-cadherin

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LIPID METABOLISM

China Medical Abstracts(Internal Medicine) 2004年第4期21卷 198-199页

2004460 Study of plasma acylation-stimulating protein in diabetic and coronary heart disease patients. LU Huiling (卢慧玲), et al. Dept Pediatr, Tongji Hosp, Tongji Med Coll, Huazhong Univ Sci & Technol, Wuhan, 430030... 详细信息

关键词： Wuhan impaired stimulating endothelium sterol metabolism apoB exerted familial enrolled

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Hematopoietic System

China Medical Abstracts(Internal Medicine) 2008年第4期25卷 225-228页

2008557 Role of multiple myeloma cells on normal endothelial cells in co-culture system. WANG Yadan(王雅丹),et al. Instit Hematol,Union Hosp,Tongji Med Coll,Huazhong Univ Sci Technol,Wuhan 430022. Chin J Hematol 2008;29(10):658-661. Objective To study the influence of multiple myeloma(MM)cells on normal endothelial cells in co-culture system in vitro. Methods A co-culture system of human MM cell line RPMI8226

关键词： myeloma familial Wuhan thalidomide 雅丹 cytometry umbilical viability cytochrome integrin

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ENDOCRINOLOGY

China Medical Abstracts(Internal Medicine) 1998年第4期15卷 199-202页