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Associations between coagulation factorⅫ,coagulation factorⅪ,and stability of venous thromboembolism:A case-control study

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World Journal of Clinical Cases 2022年第9期10卷 2700-2709页

作者： Yan Meng You Li Yan-Jun Ye Qiang Ma Jun-Bo Zhang Hao Qin Yang-Yang Deng Hong-Yan Tian Department of Peripheral Vascular Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shannxi ProvinceChina Department of Breast and Thyroid Surgery Baoji People’s HospitalBaoji 721000Shannxi ProvinceChina

BACKGROUND Pulmonary embolism(PE)is a fatal clinical syndrome that is generally caused by an embolus from unstable deep venous thrombosis(DVT).However,clinical and biochemical factors that are related to the stability of DVT are not fully *** To evaluate the relationships between plasma antigen levels of factor xii(Fxii:Ag)and factor XI(FXI:Ag)with the stability of *** Patients with DVT and no PE,DVT and PE,and controls with no DVT or PE that matched for age,gender,and comorbidities were included in this ***:Ag and FXI:Ag in peripheral venous blood were measured using enzyme-linked immunosorbent *** Using the 95th percentile of FXI:Ag in patients with DVT and PE as the cut-off,a higher FXI:Ag was associated with a higher risk of unstable DVT(odds ratio:3.15,95%confidence interval:1.18-8.43,P=0.019).Stratified analyses showed consistent results in patients≤60 years(P=0.020),but not in those>60 years(P=0.346).CONCLUSION Higher plasma FXI:Ag might be a marker for unstable DVT,which might be associated with PE in these patients.

关键词： Case-control study Deep venous thrombosis factor XI factor xii Pulmonary embolism

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An update on the genetics and pathogenesis of hereditary angioedema

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Genes & Diseases 2020年第1期7卷 75-83页

作者： Aaqib Zaffar Banday Anit Kaur Ankur Kumar Jindal Amit Rawat Surjit Singh Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Hereditary angioedema(HAE)is an uncommon genetic disorder characterized by recurrent episodes of edema involving subcutaneous tissue and *** pathogenesis of HAE reflects an intricate coordinated regulation of components of complement,kinin and hemostatic *** date,mutations in 4 different genes have been identified to cause HAE which includes serine protease inhibitor G1(SERPING1),factor xii(F12),plasminogen(PLG)and angiopoietin 1(ANGPT 1).These mutations lead to increased bradykinin 2 receptor mediated signalling via increased production of bradykinin except mutations in ANGPT1 gene that disturbs the cytoskeletal assembly of vascular endothelial *** this review we aim to summarize the recent advances in the pathogenesis and genetics of *** also provide an overview of possible future prospects in the identification of new genetic defects in HAE.

关键词： Angiopoietin 1 C1 inhibitor factor xii Genetics Hereditary angioedema Plasminogen

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