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Neuroscience Bulletin 2024年第6期40卷 707-718页

作者： Dengcheng Zhan Jingjing Zhang Songxue Su Xiuhua Ren Sen Zhao Weidong Zang Jing Cao Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China Neuroscience Research Institute Zhengzhou UniversityZhengzhou450001China

Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans;however,the underlying mechanisms remain largely *** this study,we investigated the possible contribution of interaction between ten-eleven translocation methylcytosine dioxygenase 1(TET1)and the voltage-gated K^(+)channel Kv7.2(encoded by Kcnq2)to orofacial inflammatory pain in *** found that complete Freund’s adjuvant(CFA)injection reduced the expression of Kcnq2/Kv7.2 in the trigeminal ganglion(TG)and induced orofacial inflammatory *** involvement of Kv7.2 in CFA-induced orofacial pain was further confirmed by Kv7.2 knockdown or ***,TET1 knockdown in Tet1^(flox/flox)mice significantly reduced the expression of Kv7.2 and M currents in the TG and led to pain-like ***,TET1 overexpression by lentivirus rescued the CFA-induced decreases of Kcnq2 and M currents and alleviated mechanical *** data suggest that TET1 is implicated in CFA-induced trigeminal inflammatory pain by positively regulating Kv7.2 in TG neurons.

关键词： facial pain KCNQ2 potassium channel TET1 protein

Current advances in orthodontic pain

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International Journal of Oral Science 2016年第2期8卷 67-75页

作者： Hu Long Yan Wang Fan Jian Li-Na Liao Xin Yang Wen-Li Lai State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University

Orthodontic pain is an inflammatory pain that is initiated by orthodontic force-induced vascular occlusion followed by a cascade of inflammatory responses, including vascular changes, the recruitment of inflammatory and immune cells, and the release of neurogenic and pro-inflammatory mediators. Ultimately, endogenous analgesic mechanisms check the inflammatory response and the sensation of pain subsides. The orthodontic pain signal, once received by periodontal sensory endings, reaches the sensory cortex for pain perception through three-order neurons： the trigeminal neuron at the trigeminal ganglia, the trigeminal nucleus caudalis at the medulla oblongata and the ventroposterior nucleus at the thalamus. Many brain areas participate in the emotion, cognition and memory of orthodontic pain, including the insular cortex, amygdala, hippocampus, locus coeruleus and hypothalamus. A built-in analgesic neural pathway--periaqueductal grey and dorsal raphe---has an important role in alleviating orthodontic pain. Currently, several treatment modalities have been applied for the relief of orthodontic pain, including pharmacological, mechanical and behavioural approaches and low-level laser therapy. The effectiveness of nonsteroidal anti- inflammatory drugs for pain relief has been validated, but its effects on tooth movement are controversial. However, more studies are needed to verify the effectiveness of other modalities. Furthermore, gene therapy is a novel, viable and promising modality for alleviatin~ orthodontic oain in the future.

关键词： facial pain gene therapy inflammation neural pathways trigeminal ganglion

Radiofrequency thermocoagulation rhizotomy for recurrent trigeminal neuralgia after microvascular decompression

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Chinese Medical Journal 2011年第22期124卷 3726-3730页

作者： ZHANG Liang-wen LIU Yu-guang WU Cheng-yuan XU Shu-jun ZHU Shu-gan Department of Neurosurgery Qilu Hospital 5hanctong University Jinan Shandong 250012 China

Background Microvascular decompression （MVD） is a well accepted surgical treatment strategy for trigeminal neuralgia （TN） with satisfying long-term outcome. However, considerable recurrent patients need more effective management. The purpose of this study was to evaluate the effectiveness of radiofrequency thermocoagulation rhizotomy （RTR） on patients with recurrent TN after MVD. Methods Totally 62 cases of recurrent TN after MVD undergoing RTR from January 2000 to January 2010 were retrospectively evaluated. Based on surgical procedures undertaken, these 62 cases were classified into two subgroups： group A consisted of 23 cases that underwent traditional RTR by free-hand; group B consisted of 39 cases that underwent RTR under the guidance of virtual reality imaging technique or neuronavigation system. The patients in group A were followed up for 14 to 70 months （mean, 40±4）, and those in group B were followed up for 13 to 65 months （mean, 46±7）. Kaplan-Meier analyses of the pain-free survival curves were used for the censored survival data, and the log-rank test was used to compare survival curves of the two groups. Results All patients in both groups A and B attained immediate pain relief after RTR. Both groups attained good pain relief rate within the first two years of follow-up： 92.3%, 84.6% and 82.6%, 69.6% respectively （P 〉0.05）. After 2 years, the virtual reality or neuronavigation assisted RTR group （group B） demonstrated higher pain relief rates of 82.5%, 76.2% and 68.8% at 3, 4 and 5 years after operation respectively, while those in group A was 57.2%, 49.6%, and 36.4% （P 〈0.05）. Low levels of minor complications were recorded, while neither mortalities nor significant morbidity was documented. Conclusions RTR was effective in alleviating the pain of TN cases suffering from unsuccessful MVD management. With the help of virtual reality imaging technique or neuronavigation system, the patients could attain better long-term pain relief.

关键词： radiofrequency thermocoagulation rhizotomy surgical treatment facial pain

Percutaneous Radiofrequency Thermocoagulation for the Treatment of Different Types of Trigeminal Neuralgia:Evaluation of Quality of Life and Outcomes

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第3期30卷 403-407页

作者：黄轶忠倪家骧武百山何明伟杨力强王琦 Department of pain Therapeutic Center Xuanwu HospitalCapital Medical University

Radiofrequency thermocoagulation(RFT) of the gasserian ganglion is a routine and effective technique for the treatment of classical trigeminal neuralgia(CTN).In this study we compared its efficacy in patients with CTN and atypically symptomatic or mixed trigeminal neuralgia(MTN).Fifty-seven patients were treated with RFT for trigeminal neuralgia from June 2006 to February *** patients had CTN,and 27 had *** were measured by using the visual analog pain scale(VAS) and patients’ reports of quality of life(QOL),medication usage,and complications over a follow-up period of up to 3 *** results showed that the patients with MTN were younger,tended to have bilaterial involvement of the first division,and were unresponsive to *** surgeries were completed *** 86.7% CTN patients and 48.1% MTN patients responded immediately to *** VAS scores were significantly higher in the CTN group than in MTN group(Ppain relief rates were 76.7%,73.3%,and 73.3% in the CTN group and 46.6%,41.4%,and 41.4% in the MTN group,*** rates of pain relief for both groups leveled off at 2 *** included numbness,dysesthesia,and anesthesia *** did not cause any deaths and complications were *** treatment was very effective for CTN and,to some degrees,effective for *** numbness,dysesthesia,and anesthesia dolorosa are limited to the trigger area,QOL will be greatly improved.

关键词： facial pain trigeminal neuralgia classical trigeminal neuralgia mixed trigeminal neuralgia quality of life

Thoracic visceral organs and temporomandibular joint pain:Nociceptive processing of input to the C1-C2 spinal segments

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Thoracic visceral organs and temporomandibular joint pain:No...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Robert D.FOREMAN Department of Physiology University of Oklahoma Health Science Center Oklahoma CityOK 73190USA

＜正＞Temporomandibular joint and muscle disorders include a complex and poorly understood set of conditions that can cause pain in the area of the jaw joint and associated *** is the most common symptom and is often described as a dull aching pain in the jaw joint and nearby areas,including the ***,these diseases and disorders are difficult to diagnose,because facial pain can be a symptom that represents many *** of the sources of the pain are attributed to diseases originating in the ***,the purpose of this presentation is to expand the symptoms of facial pain to include angina pectoris,which often results from ischemic heart disease.A few clinical studies have shown that patients experienced pain in the anterior maxillary areas that sometimes radiated to the neck and shoulder *** patients had normal temporomandibular joints but had severe coronary artery disease and myocardial *** is also possible that gastroesophageal reflux may also contribute to the jaw and neck pain that may mimic temporomandibular jaw *** pectoris is commonly referred to the chest and left arm,and sometimes to the right arm;however,occasionally,the pain radiates to the neck and ***,angina pectoris was treated by performing surgical sympathectomies,which relieved the pain in approximately 70%of the ***,in many of the unresponsive patients,pain was experienced in the neck and *** clinicians proposed that the vagus nerve was the pathway for producing the *** studies have also shown that the afferent fibers from the trigeminal ganglia and afferent fibers from the vagus via the nucleus tractus solitarius terminate in the C1-C3 spinal *** observations led to the hypothesis that spinothalamic tract（STT） cells of C1-C3 segments received convergent input from heart via the vagus and from somatic structures located in the neck and *** STT was studied because it transmits visceral and

关键词： visceral pain facial pain angina pectoris gastroesophageal reflux cervical spinal cord

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Sluder综合征案

World Journal of Acupuncture-Moxibustion 2020年第3期30卷 237-239页

作者：杨琪王瑞辉羊璞马星星王东陕西中医药大学针灸推拿学院中国陕西咸阳712046 陕西中医药大学医学科研实验中心中国陕西咸阳712046

A case of Sluder’s syndrome in a female patient,aged 56 years old,suffered from intermittent headache for over 20 *** therapeutic methods include acupuncture with filiform needle mainly applied to the acupoints on governor vessel,foot-shaoyang meridian and foot-yangrning meridian,the external application of Wuzhuyu(吴茱萸Fructus Evodiae)on Yongquan(涌泉KI1),as well as the pricking and bleeding method with the three-edge needle on Touwei(头维ST8).The alliance of these three therapies co-act on promoting the circulation of shaoyang and yangming meridians and governor vessel and have obtained an satisfactory clinical *** treated for 5 weeks,the symptoms all disappeared completely,such as headache,vertigo and discomfort on eyes and they were not recurred in 1-year follow-up.

关键词： Acupuncture External application Pricking and bleeding method Sluder’s syndrome Headache facial pain Sphenopalatine nerve Shaoyang pivot

Excellent response to acupuncture treatment in a case of intractable glossopharyngeal neuralgia due to vascular tortuosity: a case report

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TMR Integrative Medicine 2021年第29期5卷 1-7页

作者： Mehdy Ghaeminia Sogand Zareisedehizadeh Ali Razmkon Iranian Scientific Acupuncture Association Unit 1No.2First AlleySt.Shhydrbly(Nobakhti)Iran ApadanaTehranIran Shiraz Integrative Medical Clinic #02-01No 1Alley No 19Rajaei BoulevardFarhangshahrShirazIran Research Center for Neuromodulation and pain Shiraz University of Medical Sciences#4Exir BuildingZand BoulevardShirazIran.

Objective:Glossopharyngeal neuralgia is a relatively rare neurological condition arising from abnormal irritation of the ninth cranial *** first line of conventional treatment is pharmaceutical followed by surgical interventions in non-responsive ***,the efficacy and safety of usual therapeutic methods have limited the compliance of most affected ***:Here for the first time,we report an excellent response of a chronic case of glossopharyngeal neuralgia to traditional Chinese medicine,which is a relatively safe and not expensive therapeutic ***:Despite limited response to conventional medicine,our patient showed a fast and promising response to the combination of acupuncture and moxibustion with low doses of ***:The therapeutic protocol used for the treatment of this patient needs to be validated by further double-blinded case control studies in order to be compared to other available therapeutic methods.

关键词： Glossopharyngeal neuralgia facial pain Acupuncture Moxibustion