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fluorescent probes and functional materials for biomedical applications

Frontiers of Chemical Science and Engineering 2022年第10期16卷 1425-1437页

作者： Xi-Le Hu Hui-Qi Gan Fan-De Meng Hai-Hao Han De-Tai Shi Shu Zhang Lei Zou Xiao-Peng He Tony D.James Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Chemistry University of BathBath BA27AYUK Liver Cancer Institute Zhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China School of Materials Science and Engineering Jingdezhen Ceramic InstituteJingdezhen 333403China

Due to their simplicity in preparation,sensitivity and selectivity,fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields,facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular *** addition,many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescenceguided disease diagnosis and theranostics(e.g.,fluorogenic prodrugs).Impressive progresses have been made in the development of sensing agents and materials for the detection of ions,organic small molecules,and biomacromolecules including enzymes,DNAs/RNAs,lipids,and carbohydrates that play crucial roles in biological and disease-relevant ***,we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues“fluorescent probes”and“Molecular Sensors and Logic Gates”recently published in this journal,offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

关键词： fluorescent probes imaging cell biomedicine biomolecules

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fluorescent probes for glucolipid metabolism of bacterial cell wall

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Green Chemical Engineering 2023年第4期4卷 417-426页

作者： Yurou Huang Xiaoxie Ma Caimin Gao Yuan Xie Mingqiang Qiu Jun Yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan430079China Guangdong Provincial Key Laboratory of Radioactive and Rare Resource Utilization Shaoguan512026China

Cell wall is a basic component of bacteria that promotes bacteria to adapt the complicated environment as well as play an essential role in antimicrobial *** structure of bacterial cell wall is remarkably rich,and some complex components,such as peptidoglycan,lipopolysaccharide,and peptidoglycan-arabinogalactan et al.,can only be found in ***,the biosynthesis and transfer of these glycolipids are indispensable for bacteria during cell *** the process of biosynthesis and transfer are generally associated with metabolism and sophisticated enzyme ***,how the metabolic process takes place,what role enzymes play in this process and how they function have been major concerns for scientists in this *** significant progresses on fluorescent probes and biological imaging bring opportunity for the studying of metabolism and enzyme mechanisms recently due to its non-invasive and high *** this review,we focused on metabolic fluorescent probes for the detection of glycolipids in bacterial cell wall and highlighted the involving mechanisms and biological application.

关键词： fluorescent probes Bacteria Cell wall Glucolipid metabolism

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fluorescent probes for recognition of ATP

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Chinese Chemical Letters 2017年第10期28卷 1916-1924页

作者： Ying Wu Jia Wen Hongjuan Li Shiguo Sun Yongqian Xu Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry & Pharmacy Northwest A&F University Yangling 712100 China

Adenosine 5＇-triphosphate（ATP） not only participates in various physiological activities as the universal energy currency but also implicates in various pathological processes in living cells. Consequently,sensitive and selective detection ATP in live cells, tissues, as well as environmental samples, are urgently demanded. Due to the simple and convenient operation, economy cost, high selectivity for analyte, well biocompatibility and low cytotoxicity, fluorescent sensors for monitoring ATP have aroused great attention of researchers. In recent years, a large number of fluorescent sensors for detecting ATP have developed. This manuscript summarized most of these sensors and the interaction-mechanism between ATP and sensors, mainly including electrostatic interaction, p-p interaction, covalent bonding or hydrogen bond, or combinations of them, and the advantages of each strategy were also ***, a viewpoint of classification was shown where the sensors were divided into five typed ones according to the structure of probes used.

关键词： fluorescent probes Adenosine 5'-triphosphate(ATP) Cell imaging Sensitive detection Multi-interactions Recognition mechanism

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fluorescent probes for the detection of reactive oxygen species in human spermatozoa

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Asian Journal of Andrology 2020年第5期22卷 465-471页

作者： Sara Escada-Rebelo Francisca G Mora Ana P Sousa Teresa Almeida-Santos Artur Paiva Joao Ramalho-Santos phD Programme in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbra 3004-504Portugal Biology of Reproduction and Stem Cell Group CNC-Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbra 3004-504Portugal IIIUC-Institute for Interdisciplinary Research Casa Costa AlemaoUniversity of CoimbraCoimbra 3030-789Portugal Reproductive Medicine Unit University Hospitals of CoimbraCoimbra 3004-561Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Clinical Pathology Unit University Hospitals of CoimbraCoimbra 3004-561Portugal Department of Life Sciences University of CoimbraCoimbra 3000-456Portugal

Reactive oxygen species(ROS)production is a by-product of mitochondrial activity and is necessary for the acquisition of the capacitated state,a requirement for functional ***,an increase in oxidative stress,due to an abnormal production of ROS,has been shown to be related to loss of sperm function,highlighting the importance of an accurate detection of sperm ROS,given the specific nature of this *** this work,we tested a variety of commercially available fluorescent probes to detect ROS and reactive nitrogen species(RNS)in human sperm,to define their *** both flow cytometry(FC)and fluorescence microscopy(FM),we confirmed that MitoSOX™Red and dihydroethidium(DHE)detect superoxide anion(as determined using antimycin A as a positive control),while DAF-2A detects reactive nitrogen species(namely,nitric oxide).For the first time,we also report that RedoxSensor™Red CC-1,CellROX®Orange Reagent,and MitoPYl seem to be mostly sensitive to hydrogen peroxide,but not ***,mean fluorescence intensity(and not percentage of labeled cells)is the main parameter that can be reproducibly monitored using this type of methodology.

关键词： flow cytometry fluorescent probes human spermatozoa oxidative stress reactive oxygen species

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Hydroxylated graphene quantum dots as fluorescent probes for sensitive detection of metal ions

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 91-99页

作者： Qiang Ge Wen-hui Kong Xin-qian Liu Ying-min Wang Li-feng Wang Ning Ma Yan Li Department of Inorganic Nonmetallic Material School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Highly sensitive methods are important for monitoring the concentration of metal ions in industrial ***,we developed a new probe for the determination of metal ions by fluorescence *** probe consists of hydroxylated graphene quantum dots(H-GQDs),prepared from GQDs by electrochemical method followed by surface *** is a non-reactive indicator with high sensitivity and detection limits of 0.01μM for Cu2+,0.005μM for Al3+,0.04μM for Fe3+,and 0.02μM for Cr3+.In addition,the low biotoxicity and excellent solubility of H-GQDs make them promising for application in wastewater metal ion detection.

关键词： graphene quantum dots surface hydroxylation metal ions detection fluorescent probes

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Visualization of α_1-adrenergic receptors with phenylpiperazine-based fluorescent probes

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Science China Chemistry 2016年第5期59卷 624-628页

作者： Yuxing Lin Wenhua Li Qinying Yu Xinyang Zhou Wei Zhang Lupei Du Minyong Li Key Laboratory of Chemical Biology (Ministry of Education) Department of Medicinal Chemistry School of Pharmacy Shandong University

Several novel fluorescent probes targeting α_1-adrenergic receptors were well designed and synthesized by conjugating phenylpiperazine pharmacophore with coumarin and fluorescein fluorophores. These compounds showed suitable fluorescence property, high receptor affinity, and low cytotoxicity. Moreover, the cell imaging results displayed that these probes can be effective tools for the real-time detection of ligand-receptor interactions, as well as the visualization and location of α_1-adrenergic receptors in living cells.

关键词： α1-adrenergic receptors fluorescent probes high affinity fluorescent imaging

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Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules in live cells and in vivo

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 4-33页

作者： Yongqing Zhou Xin Wang Wei Zhang Bo Tang Ping Li College of Chemistry Chemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano Probes(Ministry of Education)Institutes of Biomedical SciencesShandong Normal UniversityJinan 250014China

The interrelationships and synergistic regulations of bioactive molecules play pivotal roles in physiological and pathological processes involved in the initiation and development of some diseases,such as cancer and neurodegenerative and cardiovascular ***,the simultaneous,accurate and timely detection of two bioactive molecules is crucial to explore their roles and pathological mechanisms in related *** imaging associated with small molecular probes has been widely used in the imaging of bioactive molecules in living cells and in vivo due to its excellent performances,including high sensitivity and selectivity,noninvasive properties,real-time and high spatial temporal *** organic molecule fluorescent probes have been successively developed to simultaneously monitor two biomolecules to uncover their synergistic relationships in living ***,in this review,we focus on summarizing the design strategies,classifications,and bioimaging applications of dual-response fluorescent probes over the past ***,future research directions in this field are proposed.

关键词： bioactive molecules fluorescent probes in living cells and in vivo review

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Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices

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Chinese Chemical Letters 2023年第11期34卷 214-219页

作者： Keliang Li Shanchao Wu Gaopan Dong Yu Li Wei Wang Guoqiang Dong Zhanying Hong Minyong Li Chunquan Sheng School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China

Kirsten rat sarcoma viral oncogene homolog(KRAS)-phosphodiesterase-delta(PDEδ)is a promising target for antitumor drug ***,highly efficient and environmentally sensitive fluorescent probes of PDEδ(DS-probes)were rationally *** compared with the reported PDEδprobes,DS-probes showed higher binding affinity and selectivity,which were able to conveniently and efficiently label PDEδin live cells as well as tumor ***,these fluorescent probes are expected to facilitate PDEδ-based mechanism elucidation,drug discovery and pathologic diagnosis.

关键词： Antitumor PDEδ fluorescent probes Environmentally sensitive Binding affinity

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Recent development in fluorescent probes based on attacking of double bond and masking of functional group

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Chinese Chemical Letters 2022年第6期33卷 2765-2772页

作者： Nadeem Ahmed Wajeeha Zareen Yong Ye Phosphorus Chemical Engineering Research Center of Henan Province The College of ChemistryZhengzhou UniversityZhengzhou 450002China

The works on the procedure of fluorescent sensors for the detection of biological analytes are extremely *** diverse analytical approaches,fluorescence is the most eye-catching due to its high sensitivity,selectivity,rapidity,robustness,ease of measurement and non-destructive ***,we show different fluorescent probes synthesized for estimation and detection of biological analytes(H_(2)S,SO_(3)^(2-)/HSO_(3)^(-),H_(2)O_(2),HOCl,HNO,ONOO^(-)).These probes were constructed by masking the functional groups (hydroxyl and amino) of fluorophore and formation of active C=C,C=N,C=O and N=N for specific *** this review we concentrate on synthesis of the probe,their photophysical properties and applications to biological studies.

关键词： fluorescent probes Hypochlorous acid Peroxynitirite Biothiols Michael addition

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Recent progress in Michael addition-based fluorescent probes for sulfur dioxide and its derivatives

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Chinese Chemical Letters 2018年第10期29卷 1456-1464页

作者： Junchao Xu Houqun Yuan Lintao Zeng Guangming Bao Institute of Veterinary Drug Jiangxi Agricultural University/Jiangxi Provincial Key Laboratory for Animal Health School of Chemistry and Chemical Engineering Tianjin University of Technology

Sulfur dioxide（SO_2） is a harmful environmental pollutant. Inhaled SO_2 can be rapidly hydrated into its derivatives, bisulfite（HSO_3^-） and sulfite（SO_3^（2-））. SO_2 derivatives are well known as preservatives and antioxidants, which are used in food and beverages to prevent oxidation and bacterial growth. Although SO_2 can be endogenously generated in mammals and exhibits unique bioactivities in regulating cardiovascular function, excessive SO_2 and its derivatives have toxic effects on humans and animals for triggering adverse reactions and diseases. A large number of fluorescent probes for SO_2 and its derivatives have been designed and reported due to their high sensitivity and selectivity, high temporal and spatial resolution, non-invasive and non-destructive detection as well as real-time visualization in situ. In this review, we have summarized the recent progress of Michael addition-based fluorescent probes for SO_2 and its derivatives. These probes are categorized and concluded according to the different α,β-unsaturated compounds（i.e., Michael acceptors）. The design strategies, sensing performances, detection mechanisms and applications of these probes are discussed in detailed. Finally, a general overview about the design of probes for SO_2 and its derivatives is provided, which will facilitate the development of ideal probes for SO_2 and its derivatives.

关键词： fluorescent probes Michael addition Sulfur dioxide Bisulfite Sulfite Application

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