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In-situ hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA damage

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 92-102页

作者： Beidou Feng Huiyu Niu Hongchen Zhai Congcong Shen Hua Zhang School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,such as genetic diseases and ***,the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biological ***,we constructed an in situ hydrophobic environment-triggering reactive fluorescence probe named *** fluorophore was 2-styrene-1H-benzo[d]imidazole,and malononitrile was introduced as a core into a molecule to initiate the hydrolysis reaction in the specific environment containing damaged mitochondrial *** this design,MBI-CN conjugates to mitochondrial DNA without causing additional ***,MBI-CN can be hydrolyzed to generate MBI-CHO in an in situ hydrophobic environment with mitochondrial DNA ***,MBI-CHO immediately emitted a significative fluorescence signal changes at 437 and 553 nm within 25 s for the damaged mitochondria *** that the specific and rapid response of MBI-CN does not cause additional damages to mitochondrial DNA,it is a potentially effective detection tool for the real-time monitoring of mitochondrial DNA damage during cell apoptosis and initial assessment of cell apoptosis.

关键词： hydrolysis reaction mitochondrial DNA damage in situ hydrophobic environment trigger fluorescence probe apoptosis

A fluorescence probe study of the mixed surfactant vesicles

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Chinese Journal of Chemistry 2000年第4期18卷 506-509页

作者：李红茹高放佟振合吴骊珠 Institute of Photographic Chemistry Chinese Academy of Sciences Beijing 100101 China Center of Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

Vesicle can be prepared from aqueous mixtures of simple commercially available, single-tailed cationic and anionic surfactants. In this work, the I3/I1 value, Ie/Im value, and fluorescence lifetime of pyrene in different systems (see the preparation of samples) were determined. The essential affecting factors in the formation of vesicle can be deduced from the obtained results. It showed that large vesicle must form naturally before sanitation in 0.082 M octyltrimethylammonium bromide and sodium laurate pH=9.2 aqueous solution. While after sonication, only small vesicle exists, which can be proved further through electron microscope.

关键词： Vesicle fluorescence probe pyrene

A Selective and Sensitive fluorescence probe for Se（IV） Based on fluorescence Quenching of Gatifloxacin

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Chemical Research in Chinese Universities 2016年第5期32卷 736-741页

作者： LIU Qing HUAN Yanfu ZHENG Qingchuan FEI Qiang FEI Yanqun FAN Qian FENG Guodong SHAN Hongyan College of Chemistry Jilin University Changchun 130021 P. R. China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University Changchun 130021 P. R. China Changchun WeiersaiBiotec Pharmaceutical Co. Ltd. Changchun 130616 P. R. China Changchun Vocational Institute of Technology Changchun 130033 P. R. China

A novel high selective and sensitive fluorescence probe termed gatifloxacin was discovered based on fluorescence ＂on-off＂ phenomenon in the presence of Se（IV）. In the Tris-HCl/acetonitrile（3：7, volume ratio, Tris-HCl 0.05 mol/L, pH=7.3） system, the fluorescence intensity of gatifloxacin was linearly decreased with the concentration increase of Se（IV） in a range of 1.0×10-5--5.0×10-5 mol/L with a correlation coefficient of 0.9979（R2=0.9958） and in a range of 5.0×10-5--1.0 ×10-4 mol/L with a correlation coefficient of 0.9973（R2=0.9946）. The detection limit of Se（IV） was 1.70×10-6mol/L.

关键词： Gatifloxacin fluorescence probe Quenching Selenium

Rational design of shortwave infrared(SWIR) fluorescence probe:Cooperation of ICT and ESIPT processes for sensing endogenous cysteine

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Chinese Chemical Letters 2022年第2期33卷 762-766页

作者： Maoju Chang Chenxu Yan Lei Shi Dan Li Wei Fu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Cysteine is well-known to be an important biothiol and related to many diseases. However, the in vivo detection of endogenous cysteine still suffers from lacking small-molecule fluorophores with both excitation and emission in the near-infrared(650-900 nm)/shortwave-infrared region. Herein, we report a molecular engineering strategy for shortwave infrared(SWIR, 900-1700 nm) sensing of cysteine, which integrated an excited-state intermolecular proton transfer(ESIPT) building block into the intramolecular charge transfer(ICT) scaffold. The obtained novel fluorophore SH-OH displays a maximum absorption at the NIR region, and emission at the SWIR region. We introduce the cysteine-recognition moiety to SH-OH structure, and demonstrate sensing of endogenous cysteine in living animals, using the SWIR emission as a reliable off-on fluorescence signal. This fluorophore design strategy of cooperation of ICT and ESIPT processes expands the in vivo sensing toolbox for accurate analysis in clinical applications.

关键词： fluorescence probe Shortwave infrared Intramolecular charge transfer Excited-state intermolecular proton transfer Near-infrared

Highly selective and turn-on fluorescence probe with red shift emission for naked-eye detecting Al^(3+)and Ga^(3+)based on metal-organic framework

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Chinese Chemical Letters 2022年第1期33卷 541-546页

作者： Linhui Wu Shuli Yao Hui Xu Tengfei Zheng Suijun Liu Jinglin Chen Na Li Herui Wen School of Chemistry and Chemical Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Materials Science and Engineering Tianjin Key Laboratory of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin 300350China

A novel ZnII-based metal-organic framework with the formula of{[Zn_(2)(BBIP)_(2)(NDC)_(2)]·H_(2)O}n(JXUST-5)derived from 3,5-bis(benzimidazol-1-yl)pyridine(BBIP)and 1,4-naphthalenedicarboxylic acid(H_(2)NDC)has been *** adjacent Zn^(II)ions are linked through two BBIP ligands to form a[Zn_(2)(BBIP)_(2)]secondary building unit(SBU).The neighbouring SBUs are further connected by NDC^(2-)withμ2-η^(1):η^(1)andμ2-η^(1):η^(1):η^(1)bridging modes to form a two-dimensional(2D)*** analysis shows that JXUST-5 could be simplified as an uninodal fes topology with a point symbol of{4.8^(2)}.Furthermore,the 2D framework net could be extended through C-H···πinteraction to form the three-dimensional supramolecular *** experiments suggest that JXUST-5 could selectively and sensitively recognize Al^(3+)and Ga^(3+)through fluorescence enhancement effect along with a relatively large red *** detection limits for Al^(3+)and Ga^(3+)are 0.17 and 0.69 ppm,***,the sensing process for both Al^(3+)and Ga^(3+)could be directly observed with naked eyes under 365 nm UV ***,JXUST-5 could be recycled at least five times as a fluorescent sensor toward Al^(3+)and Ga^(3+),which is the second example of turn-on MOF based fluorescent sensor toward Ga^(3+).

关键词： Metal-organic frameworks fluorescence probe Naked-eye detection Turn-on effect Red shift emission Al^(3+)and Ga^(3+)

A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications

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Chinese Chemical Letters 2020年第11期31卷 2955-2959页

作者： Kaijie Wang Dazhou Xi Chuantao Liu Yahui Chen Hao Gu Long Jiang Xiaoqiang Chen Fang Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China

A ratiometric probe(HBT-HBZ)bearing 2-hydrazino benzothiazole and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde for sensing hypochlorous acid(HClO)with high selectivity and sensitivity is reported in this *** fluorescence intensity ratios(I470nm/I572nm)of the probe with different concentrations of analyte showed excellent selectivity and a linear response to minor changes in *** detection limit of 24 nmol/L suggests that the sensor is very sensitive to *** to the series of performed experiments,HBT-HBZ has practical applications,such as the detection of HClO residues in tap water,which has been rarely *** addition,confocal laser microscopy experiments confirmed that HBT-HBZ can selectively recognize HClO in HeLa cells.A ratiometric probe(HBT-HBZ)for sensing HClO with high selectivity and sensitivity is reported in this *** probe exhibited high selectivity for HClO among other ROS,RNS and *** addition,HBTHBZ has some practical applications such as the analysis of the HClO content in tap ***,confocal fluorescence microscopy imaging showed that HBT-HBZ can be applied for detecting HClO in living cells.

关键词： HClO Benzothiazole fluorescence probe Tap water Bioimaging

A 4-aminonaphthalimide based environmentally sensitive fluorescence probe

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Chinese Chemical Letters 2013年第5期24卷 359-361页

作者： Zhi-Yong Wu Jing-Nan Cui Xu-Hong Qian Tian-Yu Liu State Key Laboratory of Fine Chemicals Dalian University of Technology Shanghai Key Laboratory of Chemical Biology East China University of Science and Technology

A simply synthesized 4-aminonaphthalimide derivative 1 expresses both polarity and viscosity sensitive fluorescence spectra,indicating its potential usage as an environmentally sensitive fluorescence probe. By comparing the fluorescence behavior of 1 with that of a known 4-aminonaphthalimide derivative 2,it was found that the substitution of the 4-amino group has profound influence on the environmentally sensitive fluorescence properties of 4-aminonaphthalimide.

关键词： 4-Aminonaphthalimide Environmentally sensitive fluorescence probe Substitution effects

A KIND OF fluorescence probe TO STUDY THE KINETICS OF POLYMERIZATION PROCESS

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Chinese Journal of Polymer Science 1994年第3期12卷 237-245页

作者：杨国强吴世康 Institute of Photographic Chemistry Academia Sinica Beijing 100101

fluorescence properties of 1-pheny1-3-(4'-nitrophenyl) pyrazoline (PNP) were studied inbulk polymerization process of methylmethacrylate (MMA). The fluorescence intensity of PNPwas enhanced and the emission maximum was blue shifted with the polymerization progress. Inthe period of auto-acceleration of the polymerization the enhancement of fluorescence intensityand blue shift of peak wavelength in spectra could be observed evidently. This means that thesolvatochromic properties of PNP are influenced not only by the solvent polarity but also by theviscosity of the medium (especially by the phase transitiott). In solid state PNP emits from thecharge transfer excited state without solvent relaxation. The transient emission spectra and theresults from Bakhshiev model of solvent relaxation coincide with that from the polymerizationexperiment.

关键词： fluorescence probe Polymerization Solvatochromism 1-Phenyl-3- (4′-nitrophpnyl) pyrazoline

A dynamic invertible ICT fluorescence probe: real-time monitoring of mitochondrial ATPase activity

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A dynamic invertible ICT fluorescence probe: real-time monit...