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flow cytom etric analysis of cellular dna content in epithelial ovarian tumor

Chinese Journal of Cancer Research 1992年第2期4卷 36-41页

作者：温宏武刘书文麦永嫣严仁英沈祝萱 Department of Obstetrics and Gynecology and Department of Pathology First Teaching Hospital Beijing Medical University

The dna content of tumor all was analyzed by flow cytometry on parafflnembedded specimens in 73 patients with epithelial ovarian tumor, and its clinical significance was evaluated. One of the 5 benign (20%), 2 of the 11 borderline (18.18%), and 30 of the 57 malignant (52. 63%) tumors were aneuplold. The occurrence rate of aneuploidy In malignant tumors was higher than In benign and borderline tumors ( P dna aneuploidy was higher in patients associated with ascites and the residual tumor≥.2 cm. Patients with aneuploid tumors had more of ten ascites (Ptumor size≥2cm (Pdna ptoidy and the histologic grade, histologic type of the tumors. G0/G1 cell proportion of dna diplold tumors in advanced carcinoma (64. 6%) was less than those of early stage carcinoma (75. 9% ) (Ptumor patients was higher than that of aneuploid tumor patients in the different time after operation, and the median survival time was 30. 2 months and 10. 3 months, respectively. Multivariate analysis revealed that cellular dna ploidy was the most Important predictive factor (P = 0. 007) of prognosis, followed by residual tumor size (P= 0. 05). Different tumor specimen of the same patient can exhibit variation sometime (38. 9%).The results revealed that the dna ploidy may reflect tumor biological characteristics, I. e. , Its proliferative ability. analysis of cellular dna content of epithelial ovarian tumors would help us to predict the prognosis of the patients better.

关键词： dna flow cytom etric analysis of cellular dna content in epithelial ovarian tumor

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