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An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke

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Neuroscience Bulletin 2018年第5期34卷 833-841页

作者： Binbin Nie Shengxiang Liang Xiaofeng Jiang Shaofeng Duan Qi Huang Tianhao Zhang Panlong Li Hua Liu Baoci Shan Division of Nuclear Technology and Applications Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Beijing Engineering Research Center of Radiographic Tech- niques and Equipment Beijing 100049 China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China University of the Chinese Academy of Sciences Beijing 100049 China School of Public Health and Family Medicine Capital Medical University Beijing 100069 China Physical Science and Technology College Zhengzhou University Zhengzhou 450052 China

Positron emission tomography （pet） imaging of functional metabolism has been widely used to investigate functional recovery and to evaluate therapeutic efficacy after stroke. The voxel intensity of a pet image is the most important indicator of cellular activity, but is affected by other factors such as the basal metabolic ratio of each subject. In order to locate dysfunctional regions accurately, intensity normalization by a scale factor is a prerequisite in the data analysis, for which the global mean value is most widely used. However, this is unsuitable for stroke studies. Alternatively, a specified scale factor calculated from a reference region is also used, comprising neither hyper- nor hypo-metabolic voxels. But there is no such recognized reference region for stroke studies. Therefore, we proposed a totally data-driven automatic method for unbiased scale factor generation. This factor was generated iteratively until the residual deviation of two adjacent scale factors was reduced by 〈 5%. Moreover, both simulated and real stroke data were used for evaluation, and these suggested that our proposed unbiased scale factor has better sensi- tivity and accuracy for stroke studies.

关键词： Unbiased scale factor Intensity normaliza-tion Stroke fdg-pet imaging Voxel-wise analysis

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Surveillance tools for detection of recurrent nasopharyngeal carcinoma: An evidence-based review and recommendations

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 187-204页

作者： Andrew Thamboo Kim H.Tran Annette X.Ye Issraa Shoucair Basel Jabarin Eitan Prisman Cathie Garnis St.Paul's Sinus Centre Otolaryngology Head and Neck Surgery1081Burrard StVancouverV6Z 1Y6BCCanada Department of Biomedical Physiology and Kinesiology SimonFraserUniversity8888 University DrBurnabyV5A1S6BCCanada The University of British Columbia Faculty of Medicine MDProgram317-2194Health SciencesMallVancouverV6T1Z3BCCanada British Columbia Cancer Research Centre Cancer Genetics and Developmental Biology675 W 10th AveVancouverV5Z 1L3BCCanada VancouverGeneral Hospital Otolaryngology HeadandNeckSurgery899W12thAveVancouverV5Z 1M9BCCanada

Objective: Nasopharyngeal carcinomas (NPC) are tumors arising from epithelium of the nasopharynx. The 5-year survival rate of primary NPC is 80% with significant risks of recurrence. The objective here is to provide an evidence-based systemic review of the diagnostic value of different modalities in detecting local, regional, and distal recurrent NPC, as well as the associated costs with these ***: MEDLINE, EMBASE, and the Cochrane review database were queried. Two hundred and twenty-three abstracts were generated using the inclusion criteria: patients >18 years of age;histopathological reference standard;and modalities pertaining to imaging or ***: Twenty-four manuscripts fulfilled the inclusion criteria and 5 surveillance tools identified: endoscopy, MR, fdg-pet, Tc-99m MIBI and201TI SPECT, and EBV ***: For local surveillance, endoscopy is the gold standard recommendation, with increased efficacy if Narrow Band imaging or contact endoscopy are utilized. MRI and fdg-pet is also recommended to help with local to distal spread;however, Tc-99m MIBI and201TI SPECT are options as well. EBV DNA is recommended as a cheap and accessible adjunct surveillance tool if an available as an option.

关键词： EBV DNA fdg-pet imaging MR Endoscopy Recurrent Nasopharyngeal Carcinoma

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