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Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase

引用

World Journal of Gastroenterology 2005年第17期11卷 2557-2563页

作者： Yu-Chih Liang Chih-Hsiung Wu Jan-Show Chu Chung-Kwe Wang Ling-Fang Hung Ying-Jan Wang Yuan-Soon Ho Jan-Gowth Chang Shyr-Yi Lin School of Medical Technology Taipei Medical University TaipeiTaiwanChina Department of Surgery Taipei Medical University Hospital Taipei Medical UniversityTaipeiTaiwanChina Department of Pathology School of Medicine Taipei Medical UniversityTaipeiTaiwanChina Department of Internal Medicine Taipei Municipal Jen-Ai Hospital TaipeiTaiwanChina Department of Environmental and Occupational Health National Cheng Kung University Medical College TainanTaiwanChina Department of Molecular Medicine and Laboratory Medicine China Medical University Hospital TaiwanChina Department of Internal Medicine School of Medicine Department of Internal Medicine Taipei Medical University HospitalTaipei Medical UniversityTaipeiTaiwanChina

AIM: Fatty acid-CoA ligase 4 (facl4) is an arachidonatepreferring enzyme which has been shown to be up-regulated in human colon cancer tissues and implicated in the colon tumorigenesis. The purpose of this study was to investigatethe role of facl4 in the human hepatocellular carcinoma (HCC) tumorigenesis and the specific signal pathways involved in this ***: We investigated the expression and regulation of facl4 in HCC, adjacent non-tumorous liver tissues, and cell ***: In HCC patients, we demonstrated that facl4 gene expression was markedly elevated in the cancerous tissues than in the adjacent non-cancerous liver *** addition, several human hepatoma cell lines, including Hep3B and HepG2, expressed high levels of facl4. Stable overex-pression of facl4 knockdown plasmids (small interfering RNA, siRNA) to Hep3B cells significantly decreased facl4 expression and subsequently limited the cell proliferation. Treatment of Hep3B cells with 8bromo-cAMP and SB203508 (p38 MAPK inhibitor) significantly suppressed the facl4 expression. CONCLUSION: facl4 is involved in the HCC tumorigenesis and both cAMP and p38 MAPK pathways are associated with the regulation of facl4 in HCC.

关键词： facl-4 HCC

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