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Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging

Chinese Chemical Letters 2020年第6期31卷 1382-1386,F0002页

作者： Hui Zhou Shanshan Li Xiaodong Zeng Mengxian Zhang Lin Tang Qianqian Li Deliang Chen Xianli Meng Xuechuan Hong Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese Medicine.Chengdu 611137China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE) Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals.Shenzhen Institute of Wuhan UniversityShenzhen 518057China College of Science Innovation Center for Traditional Tibetan Medicine Modernization and Quality ControlMedical CollegeTibet UniversityLasa 850000China Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry Chemistry and Chemical Engineering CollegeGannan Normal UniversityGanzhou 341000China

fluorescence imaging in the second near-infrared window(NIR-Ⅱ,1000-1700 nm)is a promising modality for real-time imaging of cancer and image-guided surgery with superior in vivo optical *** far,very few NIR-Ⅱfluorophores have been reported for in vivo biomedical imaging of chemically-induced spontaneous breast ***,a NIR-Ⅱfluorescent probe CH1055-f3 with the nucleolin-targeted tumor-homing peptide f3 was demonstrated to prefe rentially accumulate in 4 T1 *** importantly,CH1055-f3 exhibited specific NIR-Ⅱsignals with high spatial and temporal resolution,strong tumor uptake,and remarkable NIR-Ⅱimage-guided surgery in dimethylbenzanthracene(DMBA)-induced spontaneous breast tumor *** report presents the first tumor-homing peptide-based NIR-Ⅱprobe to diagnose transplantable and spontaneous breast tumors by the active targeting.

关键词： NIR-Ⅱimaging f3 peptide Image-guided surgery Spontaneous breast carcinoma NIR-Ⅱprobes

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Targeted Blue Nanoparticles as Photoacoustic Contrast Agent for Brain Tumor Delineation

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Nano Research 2011年第11期4卷 1163-1173页

作者： Aniruddha Ray Xueding Wang Yong-Eun Koo Lee Hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman Biophysics University of Michigan Ann Arbor MI 48109 USA Department of Radiology University of Michigan Ann Arbor MI 48109 USA Department of Chemistry University of Michigan Ann Arbor MI 48109 USA Department of Neurosurgery University of Michigan Ann Arbor MI 48109 USA Institute of Acoustics Naniing University Nanjing 210093 China

Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water （equivalent to 0.84 μmol/L Coomassie Blue dye）. The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.

关键词： Brain tumor surgery targeted nanoparticles f3 peptide Coomassie Blue dye photoacoustic imaging

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