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Efficacy of intraorbital electroacupuncture for diabetic abducens nerve palsy： study protocol for a prospective single-center randomized controlled trial

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Neural Regeneration Research 2017年第5期12卷 826-830页

作者： Ling-yun Zhou Xue-mei Li Tie-juan Liu Xiao-jie Ji Ming Zhao Chang Su Ji-chao Liu Jiang-yun Sun Ocular Motility Disorder Treatment & Rehabilitation Center Department of Acupuncture the First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang Province China

Abducens nerve palsy（ANP） is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups. Patients in both groups will continue their glucose-lowering therapy. A neural nutrition drug will be given to both groups for six weeks. The treatment group will also receive intraorbital electroacupuncture therapy. We will assess efficacy of treatment, eyeball movement, diplopia deviation and the levels of fasting blood-glucose and glycosylated hemoglobin before treatment at 2, 4, and 6 weeks after treatment. The efficacy and recurrence will be investigated during follow-up（1 month after intervention）. This protocol was registered at Chinese Clinical Trial Registry on 16 January 2015（Chi CTR-IPR-15005836）. This study was approved by the Ethics Committee of First Affiliated Hospital of Harbin Medical University of China（approval number： 201452）. All protocols will be in accordance with Declaration of Helsinki, formulated by the World Medical Association. Written informed consent will be provided by participants. We envisage that the results of this clinical trial will provide evidence for promoting clinical use of this new therapy for management of ANP.

关键词： nerve regeneration sixth cranial nerve peripheral nerve injury electroacupuncture diabetes mellitus eyeball movement diplopia rehabilitation ocular motility disorder intervention randomized controlled trail neural regeneration

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Effects of Intraorbital Electroacupuncture on Diabetic Abducens Nerve Palsy

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Chinese Medical Journal 2017年第14期130卷 1741-1742页

作者： Ling-Yun Zhou Tie-Juan Liu Xue-Mei Li Chang Su Jin Zhou Ocular Motility Disorder Treatment Centre The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Hematology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Diabetic abducens nerve palsy main symptoms include ocular motility disorders and *** disease is mainly caused by severe vascular *** is a serious impact on patient＇s quality of life and mental ***,there is no effective means of intervention for eye movement disorders and diplopia,the patients could only expect for neural self-repair.[1] Our team invented intraorbital electroacupuncture （IEA） therapy to repair abducens nerve affected by *** the meantime,we applied it into clinical practice and achieved great success.

关键词： Acupuncture Diabetic Abducens Nerve Palsy Diplopia Deviation eyeball movement

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