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Prevalence and risk factors for eye diseases, blindness, and low vision in Lhasa, Tibet

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 237-241页

作者： Gui-Qin Wang Zong-Xi Bai Jing Shi Sang Luo Hong-Fa Chang Xiao-Yong Sai Department of Ophthalmology Naval General Hospital Department of Ophthalmology General Hospital of Tibet Military Command Institute of Geriatrics General Hospital of Chinese PLA

AIM: To determine the prevalence and risk factors for eye diseases, blindness, and low vision in Tibet, and to assist the development of eye disease prevention and treatment ***: We carried out a survey of eye diseases among a population living at high altitude. A total of 1 115 Tibetan permanent residents aged 40 years or older from the towns and villages of Qushui County, Lhasa Prefecture, Tibet Autonomous Region, participated in this study. All participants completed a detailed questio-nnaire, and underwent presenting and pinhole visual acuity tests,and a comprehensive ophthalmic ***: There were 187 blind eyes (8.43%), 231 eyes with low vision (10.41% ). The leading cause of visual impairment was cataract of 55.0% (101/187) blindness and of 50.2% (116/231) low vision, followed by fundus lesions of 22.9% blindness and 23.8% low vision, while only a low prevalence of glaucoma of 9.6% blindness and 1.7% low vision was observed. The analysis of 2 219 eyes showed that the most common external eye disease was pterygium (27.2%) in ***: The high prevalence of blindness and low vision in the Tibetan population at high altitude is a serious public health issue. There is a need to establish and maintain an appropriate effective eye care program in Tibet.

关键词： Tibet eye diseases blindness low vision risk factors

Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina Russo Anna Longo Carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno Rosario Giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine

Mechanisms of electrical stimulation in eye diseases:A narrative review

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Advances in Ophthalmology Practice and Research 2022年第2期2卷 1-10页

作者： Jinfeng Liu Andre K.H.Ma Kwok Fai So Vincent W.H.Lee Kin Chiu Department of Ophthalmology The University of Hong KongSARHong KongChina Harrow School HarrowUK The State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongSARHong KongChina Department of Psychology The University of Hong KongSARHong KongChina Guangdong-Hong Kong-Macao Institute of Central Nervous System Regeneration Jinan UniversityGuangzhouChina

Background:In the last two decades,electrical stimulation(ES)has been tested in patients with various eye diseases and shows great treatment potential in retinitis pigmentosa and optic ***,the clinical application of ES in ophthalmology is currently *** the one hand,optimization and standardization of ES protocols is still an unmet *** the other hand,poor understanding of the underlying mechanisms has hindered clinical *** Text:Numerous experimental studies have been conducted to identify the treatment potential of ES in eye diseases and to explore the related cellular and molecular *** this review,we summarized the in vitro and in vivo evidence related to cellular and tissue response to ES in eye *** highlighted several pathways that may be utilized by ES to impose its effects on the diseased ***:Therapeutic effect of ES in retinal degenerative diseases might through preventing neuronal apoptosis,promoting neuronal regeneration,increasing neurotrophic factors production in Müller cells,inhibiting microglial activation,enhancing retinal blood flow,and modulating brain *** studies are suggested to analyse changes in specific retinal cells for optimizing the treatment parameters and choosing the best fit ES delivery method in target diseases.

关键词： Electrical stimulation eye diseases Ophthalmology Retinitis pigmentosa Optic neuropathy

Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with eye diseases in Humans and eye Toxicity in Zebrafish

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Environment & Health 2024年第6期2卷 390-400页

作者： Lu-Yin Wu Li-Xia Liang Yang Zhou Zeeshan Mohammed Zhengmin Min Qian Stephen Edward McMillin Maya Tabet Chu Chu Yuan-Yuan Fan Jia-Xin Zhou Jing-Wen Huang Wei-Hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and Health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population Health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 Health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

Mendelian randomization analysis:the causal relationship between statins and eye diseases

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Medical Data Mining 2024年第4期7卷 34-40页

作者： Lian-Tai Song Jia-Meng Wei Hao-Ting Jia Feng-Yi Zhang Qing-Fang Deng Yi-Xiao Wang Huai-Zhi Qin Qian Xu Basic Medical College Chengde Medical UniversityChengde 067000China Department of Biochemistry Chengde Medical UniversityChengde 067000China

Background:The specific role of statins in the field of ophthalmology is not *** have the advantages of pleiotropic,relatively safety and low cost,and are a promising choice for the prevention and management of eye ***,there is a divergence of findings regarding the correlation between statin treatment and ocular ***,our intention is to investigate the impact of statins on eye conditions through the utilization of Mendelian randomization(MR).Methods:The UK Biobank provided data on five statins,while the FinnGen database provided data on six eye diseases,including age-related macular degeneration,glaucoma,diabetic retinopathy,senile cataract,drug-induced cataract,and other *** exploration involved the utilization of various methods including inverse variance weighted(IVW),weighted median,weighted multivariate(weighted mode),and MR-Egger *** assess the reliability of the findings,funnel analysis,MR-Egger regression,leave-one-out method,and Cochran’s Q test were ***,reverse MR analysis was performed to evaluate the potential for reverse causality between statin use and eye ***:Based on IVW analysis,there were three pairs of positive results with significant(Peye *** analysis found that the results were *** MR analysis indicated no evidence of reverse causality between statin use and the examined eye ***:Our study finally verified the strong causal relationship between three drugs and two diseases(atorvastatin and rosuvastatin and drug cataract

关键词： Mendel randomization statins eye diseases

Microbiome as an endocrine organ and its relationship with eye diseases:Effective factors and new targeted approaches

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World Journal of Gastrointestinal Pathophysiology 2024年第5期15卷 1-18页

作者： Leila Haghshenas Sara Banihashemi Yalda Malekzadegan Roberto Catanzaro Amir Moghadam Ahmadi Francesco Marotta Department of Clinical Bioinformatics Harvard Medical SchoolBostonMA 02115United States Department of Bioscience School of Science and TechnologyNottingham Trend UniversityNottingham NG14FQUnited KingdomDepartment of BioscienceSchool of Science and TechnologyNottingham Trend UniversityNottingham NG14FQUnited Kingdom Department of Microbiology Saveh University of Medical SciencesSaveh ***Iran Department of Clinical and Experimental Medicine University of CataniaCatania 95123CataniaItaly Department of Neuroimmunology Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Department of Human Nutrition and Food Sciences Texas Women UniversityMilano 20154Italy

Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and *** studies confirm the connection between the microbiome and eye diseases,which are involved in the pathogenesis of eye diseases,including age-related macular disorders,diabetic retinopathy,glaucoma,retinitis pigmentosa,dry eye,and *** aim of this review is to investigate the microbiome in relation to eye ***,a brief introduction of the characteristics of the gut microorganisms terms of composition and work,the role of dysbiosis,the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted,then the relationship among the microbiome and the function of the immune system and eye diseases,the role of inflammation and aging and the immune system,It has been reviewed and finally,the control and treatment goals of microbiome and eye diseases,the role of food factors and supplements,biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.

关键词： Dysbiosis Gut microbiome eye diseases Inflammation Diabetic retinopatyhy Aging Nutrient supplementation

Pattern of eye diseases among Tea Workers

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Open Journal of Ophthalmology 2024年第2期14卷 117-127页

作者： Rifat Binth Rezayee Md. Showkat Kabir Mohammed Moinul Hoque Nirupam Chowdhury Mohammad Shish Rahman Nawreen Binte Anwar Shah-Noor Hassan Department of Community Ophthalmology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Ophthalmology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Background: Bangladesh’s tea industry is essential to the country’s economic expansion. Since tea workers in Bangladesh are marginalized within our community, they have limited access to comprehensive eye care services. Productivity and well-being are cornerstones of comprehensive health care strategy. Ocular disorders are influenced by life expectancy, sociodemographic status, and the epidemiological transition. In this context, the state of ocular health and the many eye illnesses remain to be significantly addressed. Purpose: To evaluate the pattern of eye diseases among tea workers in a tea estate of Bangladesh. Methods: This cross-sectional observational study was carried out in Halda Valley Tea Estate, Nazirhat, Fatickchari, Chattogram, Bangladesh, under the supervision of the Department of Community Ophthalmology, BSMMU, following ethical clearance and approval by the IRB board of BSMMU. With informed written consent and approval from the authority of the tea estate, a total of 110 tea workers were recruited. Socio-demographic characteristics, ocular findings, and patterns of eye diseases were determined and recorded. Results: The mean age of the study participants was 39.60 ± 11.63 years. The maximum (58.1%) study participants were 31 - 50 years old, female (64.5%), illiterate (82.7%), and tribal (71.8%) indigenes. eye diseases were found in 94.5% of workers. Presbyopia (28.2%), cataracts (27.3%), and refractive error (26.4%) were the most common. Tea workers with eye diseases were significantly older than those who did not have any eye diseases (40.20 ± 11.57 vs. 29.17 ± 7.31 years, p Conclusion: A significant number of tea workers had eye diseases, of which presbyopia, cataracts, and refractive error were the most common.

关键词： Tea Workers eye diseases Presbyopia Cataract Refractive Errors

Advances in single-cell sequencing technology and its application in eye diseases

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eye Science 2024年第2期1卷 128-144页

作者： Zheyao Chen Youjin Hu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060China

Vision serves as the cornerstone of rountine human life activities,wherein approximately 80%of information is perceived *** diseases,however,frequently culminate in vision impairment or blindness,severely affecting the quality of *** to the obscurity of the underlying molecular mechanisms,therapeutic outcomes for various blinding eye diseases remain *** the past decade,the development of single-cell genomics technology has made it possible to obtain multi-dimensional insights into genomes,epigenomes,transcriptomes,and proteomes of tissues and organs at the single-cell level,providing a potent tool for elucidating the molecular mechanisms of eye diseases and advancing precision ***,single-cell genomics technology has also been harnessed in drug discovery and screening,promising to transform traditional drug development paradigm that is often characterized by high cost[1],time-consuming[2],and substantial failure *** review aims to describe the cutting-edge advances in single-cell omics technology and its applications in precision diagnosis of eye diseases as well as drug discovery and screening.

关键词： single-cell multi-omics eye diseases drug discovery

Artificial intelligence,machine learning and deep learning for eye care specialists

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Annals of eye Science 2020年第2期5卷 82-94页

作者： Rory Sayres Naama Hammel Yun Liu Google Health Palo AltoCA 94304USA

Artificial intelligence(AI)methods have become a focus of intense interest within the eye care *** parallels a wider interest in AI,which has started impacting many facets of ***,understanding across the community has not kept pace with technical *** is AI,and how does it relate to other terms like machine learning or deep learning?How is AI currently used within eye care,and how might it be used in the future?This review paper provides an overview of these concepts for eye care *** explain core concepts in AI,describe how these methods have been applied in ophthalmology,and consider future directions and *** walk through the steps needed to develop an AI system for eye disease,and discuss the challenges in validating and deploying such *** argue that among medical fields,ophthalmology may be uniquely positioned to benefit from the thoughtful deployment of AI to improve patient care.

关键词： Artificial intelligence(AI) ophthalmology deep learning eye diseases