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Complete response to radiation therapy of orbital metastasis from hepatocellular carcinoma

World Journal of Gastroenterology 2009年第47期15卷 6000-6003页

作者： Allison M Quick Mark Bloomston Edward Y Kim Nathan C Hall Nina A Mayr Department of Radiation Medicine Arthur G.James Cancer HospitalThe Ohio State University Medical CenterColumbusOH 43210 United States Department of Surgical Oncology The Ohio State University Medical CenterColumbusOH 43210 United States Department of Radiology The Ohio State University Medical CenterColumbusOH 43210United States

The incidence of hepatocellular carcinoma(HCC)is increasing in the United States,and 50%-75%o patients with HCC will develop metastatic disease Orbital metastases from HCC are extremely *** report the case of a 52-year-old male with known metastatic HCC,who presented with severe proptosis and *** orbital mass was identified on magnetic resonance imaging(MRI)and confirmed to have hypermetabolic activity on positron emission tomography/computed *** received a palliative course of external beam radiation therapy to the right *** modulated radiation therapy (IMRT)was used to allow sparing of critical norma tissues in close proximity to the *** month after completion of IMRT to 58 Gray in 30 fractions delivered over 6 wk,the patient had a complete clinical,radiologic(MRI)and symptomatic response The patient continues to have local control in the orbi 1.7 years after therapy *** critical norma structures were kept below the tolerance dose using IMRT,and no toxicities were observed.

关键词： Hepatocellular carcinoma eye neoplasms Metastasis Intensity modulated radiation therapy Palliative therapy

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Expression of CD44V6 and PCNA in squamous cell carcinomas

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Chinese Medical Journal 2002年第10期115卷 1564-1568页

作者：牛膺筠周占宇王红云刘夫玲青岛大学医学院附属医院眼科山东266003 青岛市第八人民医院眼科山东266003

OBJECTIVE: To investigate the expression of cluster of differentiation 44 variant 6 (CD(44V6)) and proliferating cell nuclear antigen (PCNA) in ocular squamous cell carcinomas. METHODS: Streptavidin-biotin complex (SABC) immunohistochemistry was used to explore the expression of CD(44V6) and PCNA in 35 cases of ocular squamous cell carcinomas, 20 cases of papillomas, and 11 cases of normal eyelid tissue. RESULTS: The CD(44V6) positive rate was 62.9% (22/35) in ocular squamous cell carcinomas, 15.0% (3/20) in papillomas, but not detectable in the 11 cases of normal eyelid tissue. The positive expression rates of CD(44V6) in ocular squamous cell carcinomas were significantly higher than in benign tumors (chi(2) = 11.57, P

关键词： Antigens, CD44 Carcinoma, Squamous Cell eye neoplasms Glycoproteins Humans Immunohistochemistry Lymphatic Metastasis Proliferating Cell Nuclear Antigen Skin

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